Zobrazeno 1 - 10
of 63
pro vyhledávání: '"H. Blackburn"'
Autor:
Bo Huang, Juan Guan, Jen Hsuan Wei, Guido Stadler, Tracy T. Chow, Elizabeth H. Blackburn, Xiaoyu Shi
Publikováno v:
Nature communications, vol 9, iss 1
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Enhanced telomere maintenance is evident in malignant cancers. While telomeres are thought to be inherently heterochromatic, detailed mechanisms of how epigenetic modifications impact telomere protection and structures are largely unknown in human ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd16285f975f74b681ad187e997f573
https://escholarship.org/uc/item/19w6q6sf
https://escholarship.org/uc/item/19w6q6sf
Publikováno v:
Science. 350:1193-1198
Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes. Telomere attrition can lead to potentially maladaptive cellular changes, block cell division, and interfere with tissue replenishment. Recent advances in the underst
Autor:
Andrew Steptoe, Argita Zalli, Livia A. Carvalho, Mark Hamer, Jorge D. Erusalimsky, Elizabeth H. Blackburn, Jue Lin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 12
Recent work has linked psychological stress with premature cellular aging as indexed by reduced leukocyte telomere length. The combination of shorter telomeres with high telomerase activity (TA) may be indicative of active cell stress. We hypothesize
Autor:
Patrick Byanyima, William Worodria, Emmanuel Musisi, Elizabeth Auld, J. Lucian Davis, Elizabeth H. Blackburn, Emily Chang, Mark R. Segal, Irene Ayakaka, Jue Lin, Laurence Huang
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163153 (2016)
Auld, E; Lin, J; Chang, E; Byanyima, P; Ayakaka, I; Musisi, E; et al.(2016). HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis. PLOS ONE, 11(9). doi: 10.1371/journal.pone.0163153. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2sv6h3b7
PLoS ONE
PloS one, vol 11, iss 9
Auld, E; Lin, J; Chang, E; Byanyima, P; Ayakaka, I; Musisi, E; et al.(2016). HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis. PLOS ONE, 11(9). doi: 10.1371/journal.pone.0163153. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2sv6h3b7
PLoS ONE
PloS one, vol 11, iss 9
Introduction HIV infection is a risk factor for opportunistic pneumonias such as tuberculosis (TB) and for age-associated health complications. Short telomeres, markers of biological aging, are also associated with an increased risk of age-associated
Autor:
Elissa S. Epel, Sarah Goglin, Ramin Farzaneh-Far, Mary A. Whooley, Jue Lin, Elizabeth H. Blackburn
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0160748 (2016)
PLoS ONE
PloS one, vol 11, iss 10
PLoS ONE
PloS one, vol 11, iss 10
Author(s): Goglin, Sarah E; Farzaneh-Far, Ramin; Epel, Elissa S; Lin, Jue; Blackburn, Elizabeth H; Whooley, Mary A | Abstract: BackgroundShort telomere length independently predicts mortality in patients with coronary heart disease. Whether 5-year ch
Autor:
Jue Lin, Elissa S. Epel, Nancy E. Adler, Firdaus S. Dhabhar, Richard M. Cawthon, Jason D. Morrow, Elizabeth H. Blackburn
Publikováno v:
Proceedings of the National Academy of Sciences. 101:17312-17315
Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms of how stress gets “under the skin” remain elus
Publikováno v:
Proceedings of the National Academy of Sciences. 97:11409-11414
Mutations in the template region of a telomerase RNA gene can lead to the corresponding sequence alterations appearing in newly synthesized telomeric repeats. We analyzed a set of mutations in the template region of the telomerase RNA gene ( TER1 ) o
Publikováno v:
Science. 288:863-867
The telomerase ribonucleoprotein has a phylogenetically divergent RNA subunit, which contains a short template for telomeric DNA synthesis. To understand how telomerase RNA participates in mechanistic aspects of telomere synthesis, we studied a conse
Publikováno v:
Science. 326:656-658
Until this month, women had never won more than one Nobel science prize in a single year. This year's quartet of laureates talk about what their success might mean for science and society.
Publikováno v:
Proceedings of the National Academy of Sciences. 96:3616-3621
We have identified telomerase activity in extracts of three evolutionarily diverse kinetoplastid species: Trypanosoma brucei, Leishmania major , and Leishmania tarentolae . Telomerase activity was initially detected in extracts from insect form cells