Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Glenn Dranoff"'
Autor:
Soumya Badrinath, Maxence O. Dellacherie, Aileen Li, Shiwei Zheng, Xixi Zhang, Miguel Sobral, Jason W. Pyrdol, Kathryn L. Smith, Yuheng Lu, Sabrina Haag, Hamza Ijaz, Fawn Connor-Stroud, Tsuneyasu Kaisho, Glenn Dranoff, Guo-Cheng Yuan, David J. Mooney, Kai W. Wucherpfennig
Publikováno v:
Nature. 606:992-998
Most cancer vaccines target peptide antigens, necessitating personalization owing to the vast inter-individual diversity in major histocompatibility complex (MHC) molecules that present peptides to T cells. Furthermore, tumours frequently escape T ce
Autor:
Zheng Yan, Raphael Thierry, Antoine deWeck, Claire Fabre, Felipe Correa Geyer, Joel Wagner, Oleg Iartchouk, Jeffrey A. Engelman, Beverly Nguyen, Rohan Diwanji, James Deeds, Julie Chen, Quincey Simmons, Naiyan Chen, Viviana Cremasco, Jonathan Chang, Joseph X. Zhou, Matt Hims, Yenyen Yu, Shaobu Weng, Pushpa Jayaraman, Stephanie Schwartz, David A. Ruddy, Michelle Piquet, Vera M. Ruda, Nathaniel D. Kirkpatrick, Pavitra Chikkegowda, Mirek Dostalek, Iulian Pruteanu-Malinici, Brian Minie, Glenn Dranoff, Markus Riester, Marc Pelletier, Alina Raza, Angelo Grauel, Kenzie MacIsaac, Jincheng Wu, Tyler Laszewski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Despite the increasing interest in targeting stromal elements of the tumor microenvironment, we still face tremendous challenges in developing adequate therapeutics to modify the tumor stromal landscape. A major obstacle to this is our poor understan
Autor:
Yvonne Y. Li, Grit S. Herter-Sprie, Daniel B. Costa, Scott J. Rodig, Jeffrey A. Engelman, Amanda J. Redig, Esra A. Akbay, Kwok-Kin Wong, Shohei Koyama, Leena Gandhi, Kevin A. Buczkowski, Bruce E. Johnson, Peter S. Hammerman, Glenn Dranoff, Sidharta P. Gangadharan, William G. Richards, Sangeetha Palakurthi, Peter E. Fecci, F. Stephen Hodi, Gordon J. Freeman, Hajime Asahina, Meghana M. Kulkarni, Mari Kuraguchi, Pasi A. Jänne, Raphael Bueno, Robert E. Jones
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications
Nature Communications
Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. In this study, to elucidat
Autor:
Manav Gupta, Anil K. Rustgi, Amanda J. Redig, Xiaoen Wang, Xin Zhang, Adam J. Bass, Kwok-Kin Wong, Shuai Li, Zhao Chen, Peter S. Hammerman, Shohei Koyama, Gang Lu, Lynette M. Sholl, Stephanie Tuminello, Mei Zheng, Margherita Paschini, Christine Fillmore Brainson, J. Alan Diehl, Sangeetha Palakurthi, Nabeel Bardeesy, Norman E. Sharpless, Bryan P. Marsh, Grit S. Herter-Sprie, Chunxiao Xu, Carolina Garcia-de-Alba, Glenn Dranoff, Haikuo Zhang, Ting Chen, Esra A. Akbay, Carla F. Kim, Hongbin Ji, Dieter Saur, Hideo Watanabe, David J. Kwiatkowski
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autoc
Autor:
Kai W. Wucherpfennig, Rong En Tay, Lucas Ferrari de Andrade, Bettina Franz, Christopher Harvey, Kenneth F. May, Guo-Cheng Yuan, Soumya Badrinath, Jason Pyrdol, Adrienne M. Luoma, Sebastian Kobold, Daphne Tsoucas, Charles H. Yoon, Deng Pan, F. Stephen Hodi, Yoshinaga Ito, Glenn Dranoff
Publikováno v:
Science (New York, N.Y.). 359(6383)
Helping NK cells find their way MICA and MICB proteins can be expressed on tumors and act as “kill me” signals to the immune system. But tumors often disguise themselves by shedding these proteins, which prevents specialized natural killer (NK) c
Autor:
Peter S. Hammerman, Ting Chen, Anil K. Rustgi, Hongbin Ji, Stephanie Tuminello, Glenn Dranoff, Zhao Chen, Gang Lu, Nabeel Bardeesy, Xin Zhang, Haikuo Zhang, Norman E. Sharpless, Amanda J. Redig, Esra A. Akbay, Adam J. Bass, Hideo Watanabe, Xiaoen Wang, Kwok-Kin Wong, Shohei Koyama, Shuai Li, Manav Gupta, Dieter Saur, Bryan P. Marsh, J. Alan Diehl, Carolina Garcia-de-Alba, Lynette M. Sholl, David J. Kwiatkowski, Mei Zheng, Christine Fillmore Brainson, Sangeetha Palakurthi, Grit S. Herter-Sprie, Chunxiao Xu, Margherita Paschini, Carla F. Kim
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autoc
Publikováno v:
Nature. 480:480-489
Activating the immune system for therapeutic benefit in cancer has long been a dream of some immunologists, and even a few oncologists. After decades of disappointment, the tide has finally changed due to the success of recent proof-of-concept clinic
Autor:
Martin C. Mihm, Matthew Vanneman, Vincent T. Ho, Yoon Joong Kang, Robert J. Soiffer, Haesook T. Kim, Joseph H. Antin, Glenn Dranoff, Stefanie Sarantopoulos, Edwin P. Alyea, John Koreth, Jerome Ritz, Corey Cutler, Tetsuro Sasada, Mildred Pasek, Christine Canning, Jeffery L. Kutok
Publikováno v:
Proceedings of the National Academy of Sciences. 106:15825-15830
Through an immune-mediated graft-versus-leukemia effect, allogeneic hematopoietic stem cell transplantation (HSCT) affords durable clinical benefits for many patients with hematologic malignancies. Nonetheless, subjects with high-risk acute myeloid l
Autor:
Michael T. Jaklitsch, Frank G. Haluska, Marybeth Nelson, Sara Russell, James P. Allison, Darryl A. Oble, Alan J. Korman, Glenn Dranoff, Nikhil H. Ramaiya, F. Stephen Hodi, Suzanne MacRae, Christine Canning, Israel Lowy, Donna Neuberg, Teresa C. Chen, David B. Lautz, Martin C. Mihm, Marcus O. Butler, Michael V. Seiden, Andrea Kruse
Publikováno v:
Proceedings of the National Academy of Sciences. 105:3005-3010
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking monoclonal antibodies to advanced-cancer patients incr
Autor:
Daniel R. Carrasco, Glenn Dranoff, Nikhil C. Munshi, Yu-Tzu Tai, Jerome Ritz, Kenneth C. Anderson, Donna Neuberg, Matthew Vanneman, Rao Prabhala, Masahisa Jinushi
Publikováno v:
Proceedings of the National Academy of Sciences. 105:1285-1290
Monoclonal gammopathy of undetermined significance (MGUS) is a common disorder of aging and a precursor lesion to full-blown multiple myeloma (MM). The mechanisms underlying the progression from MGUS to MM are incompletely understood but include the