Zobrazeno 1 - 10
of 23
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Trabszo, Christof, Ramms, Bastian, Chopra, Pradeep, Lüllmann-Rauch, Renate, Stroobants, Stijn, Sproß, Jens, Jeschke, Anke, Schinke, Thorsten, Boons, Geert-Jan, Esko, Jeffrey, Lübke, Torben, Dierks, Thomas, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery
Publikováno v:
Biochemical Journal, 477(17). Portland Press Ltd.
Biochem J
Biochem J
Mucopolysaccharidoses comprise a group of rare metabolic diseases, in which the lysosomal degradation of glycosaminoglycans (GAGs) is impaired due to genetically inherited defects of lysosomal enzymes involved in GAG catabolism. The resulting intraly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea602d018494379fb323a0b52cb4d810
https://doi.org/10.1042/bcj20200546
https://doi.org/10.1042/bcj20200546
PURPOSE. Retinal degeneration is a common feature of several lysosomal storage disorders, including the mucopolysaccharidoses, a group of metabolic disorders that is characterized by widespread accumulation of glycosaminoglycans due to lysosomal enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a899de0b25eb16d98389942cb29a949
https://pub.uni-bielefeld.de/record/2904124
https://pub.uni-bielefeld.de/record/2904124
Autor:
Peter Heimann, Thomas Dierks, Markus Damme, Steven U. Walkley, Tomo Sawada, Theresa Ortkras, Björn Kowalewski, Renate Lüllmann-Rauch
Publikováno v:
Human molecular genetics. 24(7)
Deficiency of arylsulfatase G (ARSG) leads to a lysosomal storage disease in mice resembling biochemical and pathological features of the mucopolysaccharidoses and particularly features of mucopolysaccharidosis type III (Sanfilippo syndrome). Here we
Autor:
Renate Lüllmann Rauch, Volkmar Gieselmann, Diana Klein, Jan-Eric Månsson, Ulrich Matzner, Dieter Hartmann, Klaus Harzer, Rudi D'Hooge, Peter D. DeDeyn
Publikováno v:
Philosophical transactions of the Royal Society: B: biological sciences
Lysosomal storage diseases comprise a group of about 40 disorders, which in most cases are due to the deficiency of a lysosomal enzyme. Since lysosomal enzymes are involved in the degradation of various compounds, the diseases can be further subdivid
Akademický článek
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Autor:
Renate Lüllmann-Rauch, M. Ziegenhagen
Publikováno v:
Histochemistry. 95:263-268
The purpose of the present investigation was to examine whether or not a di-cationic amphiphilic compound that is known (1) to be accumulated in lysosomes and (2) to form insoluble complexes with sulfated glycosaminoglycans (sGAG) in vitro, is able t
Publikováno v:
Archives of Toxicology. 64:291-298
The purpose of the present investigation was to establish a cell culture system suitable for demonstrating the drug-induced lysosomal storage of sulfated glycosaminoglycans (GAGs). This is a drug side-effect which was previously studied in animals tr
Publikováno v:
Xenobiotica. 20:1259-1267
1. Drug accumulation without a concomitant elevation of blood level may occur if the capacity of the tissue to bind drug increases during chronic treatment. 2. This special type of accumulation is found with cationic-amphiphilic drugs, which induce t
Publikováno v:
Toxicology and applied pharmacology. 114(2)
In the accompanying paper, four dibasic acridine derivatives were reported to induce lysosomal storage of sulfated glycosaminoglycans (sGAG), i.e., mucopolysaccharidosis, in cultured fibroblast (Handrock et al. Toxicol. Appl. Pharmacol. 114, 1992). T
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Eye and Ear ISBN: 9783642766428
Drug-induced lipidosis and mucopolysaccharidosis in the cornea of rats have not been reported to be recognizable by the naked eye. Some lipidosis-inducing drugs (chlorphenter-mine, chloroquine, tilorone) cause an anterior polar cataract of the lens,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a988cd9d336a4b5599b838e7ae7f10b0
https://doi.org/10.1007/978-3-642-76640-4_4
https://doi.org/10.1007/978-3-642-76640-4_4