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pro vyhledávání: '"Navedul Haque"'
Autor:
Madhubhai M. Patel, Mustakim Mansuri, Navedul Haque, Khurshid I. Molvi, Syed Muzaffar A. Andrabi, V. Sudarsanam
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 23(6)
Sets of tetrasubstituted thiophene esters 4a-4g, 5a-5f and 6a-6e were synthesized by reaction of 1-(alpha-Carbomethoxy-beta-aminothiocrotonoyl)-aryl/aroyl amines (3) with 3-(bromoacetyl)coumarin, 1,4-dibromodiacetyl and chloroacetone respectively. Th
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 23(6)
A new series of tetrasubstituted thiophene analogues (4a-4f, 5a-5f and 8a-8i) were designed incorporating the pharmacophoric features of COX-1 (as in fenamates), 5-LOX and the p38 MAP kinase inhibitors. The designed series was synthesized by nucleoph