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pro vyhledávání: '"Ai-Yun Peng"'
Publikováno v:
Chemico-biological interactions. 204(2)
We have recently synthesized a series of phosphorylated flavonoids and identified some of them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity for CEase over acetylcholinesterase (AChE). In the present paper
Publikováno v:
European journal of medicinal chemistry. 45(5)
Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in atherosclerosis and for the development of hypocholesterolemic agents, there are increasing interests in designing and synthesizing CEase inhibitors. In the pre
Autor:
Yi-Xiang Ding, Ai-Yun Peng
Publikováno v:
Journal of the American Chemical Society. 125:15006-15007
Cu(I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoethyl esters was examined, and a new class of six-membered phosphorus heterocycles was formed with high regioselectivity and good yields. The present reaction is the fir
Publikováno v:
Organic & Biomolecular Chemistry. 9:2530
Five flavones possessing one to four phenolic groups were fully phosphorylated efficiently and the obtained compounds showed excellent pancreatic cholesterol esterase (CEase) inhibitory activities with IC(50) in the nanomolar range, which were much m