Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Yueping Zhang"'
Autor:
L.V.J. Sankara Sivaprasad, Bokka Venkata Murali, T. Thanga Mariappan, Sushma Basavanthappa, Avinash Annasao Hadambar, Vijaykumar Kuchibhotla, Avisek Deyati, Bradley A. Zinker, Gowtham Raj Gunti, Manjunath Ramarao, Sagnik Chatterjee, Shashyendra Singh Gautam, Yueping Zhang, Tanvi Naik, Hong Shen, Sambuddho Mukherjee, Michael Sinz
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:29-39
Expression and functional changes in the organic anion transporting polypeptide (OATP)-multidrug resistance-associated protein (MRP) axis of transporters are well reported in patients with nonalcoholic steatohepatitis (NASH). These changes can impact
Autor:
T. Thanga Mariappan, Petia Shipkova, Joseph L. Cantone, Prabhakar Rajanna, Hong Shen, Jinping Gan, W. Griffith Humphreys, Shashyendra Singh Gautam, Dieter M. Drexler, Yueping Zhang, Vinay K. Holenarsipur, Punit Marathe
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 368:136-145
Plasma pyridoxic acid (PDA) and homovanillic acid (HVA) were recently identified as novel endogenous biomarkers of organic anion transporter (OAT) 1/3 function in monkeys. Consequently, this clinical study assessed the dynamic changes and utility of
Autor:
R. Marcus Fancher, Hong Shen, Pawel D. Puszczalo, Shen-Jue Chen, Xue-Qing Chen, David J. Shuster, Cliff Chen, Zheng Yang, Yueping Zhang, Michael Sinz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 375(1)
Organic anion-transporting polypeptide (OATP) 1B induction is an evolving mechanism of drug disposition and interaction. However, there are contradictory reports describing OATP1B expression in hepatocytes and liver biopsies after administration of a
Autor:
David M. Nelson, Yurong Lai, Weiqi Chen, Shen-Jue Chen, Yueping Zhang, Pamela Abraham, Chris Freeden, W. Griffith Humphreys, Yaofeng Cheng, Jinping Gan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:385-394
The interference of bile acid secretion through bile salt export pump (BSEP) inhibition is one of the mechanisms for troglitazone (TGZ)-induced hepatotoxicity. Here, we investigated the impact of single or repeated oral doses of TGZ (200 mg/kg/day, 7
Publikováno v:
Molecules
Volume 24
Issue 14
Molecules, Vol 24, Iss 14, p 2667 (2019)
Volume 24
Issue 14
Molecules, Vol 24, Iss 14, p 2667 (2019)
First-principles calculations based on the density functional theory (DFT) were carried out to study the atomic structure and electronic structure of LiAl2(OH)6Cl, the only material in the layered double hydroxide family in which delithiation was fou
Publikováno v:
Molecular pharmaceutics. 16(6)
Identification of a selective inhibitor of organic anion transporting polypeptide (OATP) 1B1 is critical in order to determine the contribution of OATP1B1-mediated uptake of investigational drugs into human hepatocytes for successful in vitro-to-in v
Autor:
Rommel G. Tirona, José Domingos Santos da Silva, Albert P. Li, Edwin C. Y. Chow, K. Sandy Pang, Yurong Lai, Yueping Zhang, Jason Z Ya Wang, Holly P. Quach, David C. Evans
Publikováno v:
Paediatrics Publications
The humanized liver mouse model is being exploited increasingly for human drug metabolism studies. However, its model stability, intercommunication between human hepatocytes and mouse nonparenchymal cells in liver and murine intestine, and changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c69f00033352b0f8a5656cc2809930
https://ir.lib.uwo.ca/paedpub/1812
https://ir.lib.uwo.ca/paedpub/1812
Autor:
Tongtong Liu, W. Griffith Humphreys, Maureen Bourner, David C. Thompson, Punit Marathe, Hong Shen, Jennifer Pratt, Yueping Zhang, Yongling Xiao, Yurong Lai, Xi Qiu
Publikováno v:
Molecular pharmaceutics. 13(4)
In the present study, we characterized in vitro biosynthesis and disposition of bile acids (BAs) as well as hepatic transporter expression followed by ABCB11 (BSEP) gene knockout in HepaRG cells (HepaRG-KO cells). BSEP KO in HepaRG cells led to time-
Autor:
Robert J. Schmidt, Benjamin J. Henley, Celia D’Arienzo, Jonathan Lippy, John S. Sack, Yueping Zhang, Yongmi An, John T. Hunt, Amrita Kamath, John S. Tokarski, Barri Wautlet, Veeraswamy Manne, Dianlin Xie, Punit Marathe, Donna D. Wei, Louis J. Lombardo, Kyoung S. Kim, Robert Jeyaseelan, David K. Williams, Joseph Fargnoli, Liping Zhang, Yaquan Zhang, Johnni Gullo-Brown, Zhen-Wei Cai, George L. Trainor, Robert M. Borzilleri
Publikováno v:
Journal of Medicinal Chemistry. 51:5330-5341
Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor with an IC50 value of 1.8 nM. Further SAR of the 2-pyridone based inhibitors of Met kinase led to potent 4-pyridone and pyridine N-oxide inhibitors such as 3 and 4. T
Autor:
Amrita Kamath, Yongmi An, John T. Hunt, Punit Marathe, Veeraswamy Manne, Zhen-Wei Cai, Donna D. Wei, John S. Sack, Robert J. Schmidt, Yueping Zhang, Robert M. Borzilleri, Kyoung S. Kim, Cornelius Lyndon A M, Gretchen M. Schroeder, David K. Williams, Xiao-Tao Chen, Joseph Fargnoli, Louis J. Lombardo, John S. Tokarski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3224-3229
A series of acylurea analogs derived from pyrrolopyridine and aminopyridine scaffolds were identified as potent inhibitors of Met kinase activity. The SAR at various positions of the two kinase scaffolds was investigated. These studies led to the dis