Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ryo, Ito"'
Autor:
Ryo Ito, Hanae Morio, Tomoyo Baba, Yasuyuki Sakaguchi, Naomi Wakayama, Ryuto Isogai, Yoshiyuki Yamaura, Takafumi Komori, Tomomi Furihata
Publikováno v:
Pharmaceutical Research. 39:1575-1586
In vitro human blood-brain barrier (BBB) models in combination with central nervous system-physiologically based pharmacokinetic (CNS-PBPK) modeling, hereafter referred to as the "BBB/PBPK" method, are expected to contribute to prediction of brain dr
Autor:
Kensuke, Sakuma, Noriko, Tsubooka-Yamazoe, Kiyohiro, Hashimoto, Nozomu, Sakai, Shinya, Asano, Saori, Watanabe-Matsumoto, Takeshi, Watanabe, Bunnai, Saito, Hirokazu, Matsumoto, Hikaru, Ueno, Ryo, Ito, Taro, Toyoda
Publikováno v:
Stem Cell Research & Therapy. 14
[Background] Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the safety of
Autor:
Keita Kitamura, Ayaka Okamoto, Hanae Morio, Ryuto Isogai, Ryo Ito, Yoshiyuki Yamaura, Saki Izumi, Takafumi Komori, Shingo Ito, Sumio Ohtsuki, Hidetaka Akita, Tomomi Furihata
Publikováno v:
Molecular pharmaceutics. 19(8)
Blood-brain barrier (BBB)-permeable middle- or macromolecules (middle/macromolecules) have recently attracted significant attention as new drug delivery carriers into the human brain via receptor-mediated transcytosis (RMT). During the development pr
Autor:
Ryo Ito, Yoshitomi Yayoi, Koji Watanabe, Teruki Hamada, Yasuhiro Hirata, Yasufumi Miyamoto, Seiji Miwatashi, Nobuyuki Takakura, Kazuaki Takami, Yoshihiko Hirozane, Naoyoshi Noguchi, Yusuke Moritoh, Mitsugi Ookawara, Hideki Furukawa, Jumpei Aida, Masanori Watanabe, Hitomi Yuko, Tsuyoshi Maekawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10352-10379
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 a
Autor:
Shota Suzuki, Saki Izumi, Ken-ichi Nunoya, Takafumi Komori, Ryo Ito, Haruo Imawaka, Hidetaka Akita, Kenta Umehara, Keita Kitamura, Tomomi Furihata, Naomi Wakayama, Naohiko Anzai, Yoshiyuki Yamaura
Publikováno v:
Molecular pharmaceutics. 16(11)
Brain microvascular endothelial cells (BMEC), together with astrocytes and pericytes, form the blood-brain barrier (BBB) that strictly restricts drug penetration into the brain. Therefore, in central nervous system drug development, the establishment
Autor:
Hitomi Ogino, Tsuyoshi Maekawa, Masanori Watanabe, Mitsugi Ookawara, Koji Takeuchi, Yusuke Moritoh, Hirohisa Miyashita, Hikaru Ueno, Akihiro Kobayashi, Shin-ichi Abe, Nobuhiro Nishigaki, Tomoki Yoshihara, Yukio Yamada, Yoshiyuki Tsujihata, Ryo Ito, Yasufumi Miyamoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 370(2)
The GPR40/FFA1 receptor is a G-protein-coupled receptor expressed in the pancreatic islets and enteroendocrine cells. Here, we report the pharmacological profiles of (3S)-3-cyclopropyl-3-{2-[(1-{2-[(2,2-dimethylpropyl)(6-methylpyridin-2-yl)carbamoyl]
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 357:217-227
Sulfonylureas (SUs) are widely used insulin secretagogues, but they have adverse effects including hypoglycemia and secondary failure. Fasiglifam/TAK-875, a selective GPR40 agonist, enhances glucose-stimulated insulin secretion and improves hyperglyc
Autor:
Keita Kitamura, Shota Suzuki, Hanae Morio, Naohiko Anzai, Kan Chiba, Hidetaka Akita, Kenta Umehara, Ryo Ito, Yoshiro Saito, Mari Hashimoto, Tomomi Furihata, Kosuke Saito
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 4, Pp 350-358 (2018)
Astrocytes have shown longstanding promise as therapeutic targets for various central nervous system diseases. To facilitate drug development targeting astrocytes, we have recently developed a new conditionally immortalized human astrocyte cell line,
Autor:
Shuji Kitamura, Nobuyuki Negoro, Nobuhiro Suzuki, Tsuneo Yasuma, Yu Momose, Masami Suzuki, Naoyuki Kanzaki, Satoshi Mikami, Takashi Santou, Ryo Ito, Shinobu Sasaki, Takeshi Miyazaki, Junichi Miyazaki, Yoshiyuki Tsujihata, Toshimasa Tanaka, Miyuki Funami
Publikováno v:
Journal of Medicinal Chemistry. 55:3756-3776
As part of a program to identify potent GPR40 agonists with drug-like properties suitable for clinical development, the incorporation of polar substituents was explored with the intention of decreasing the lipophilicity of our recently disclosed phen
Autor:
Tsuneo Yasuma, Ryo Ito, Masami Suzuki, Koji Takeuchi, Ayako Harada, Yoshiyuki Tsujihata, Yu Momose, Nobuyuki Negoro
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 339:228-237
G protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFA(1)) is highly expressed in pancreatic β cells and mediates free fatty acid-induced insulin secretion. This study examined the pharmacological effects and potential for avoidance of