Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Nicolas Ferry"'
Publikováno v:
Human Gene Therapy. 24:143-151
Lentiviral vectors are efficient gene delivery vehicles for therapeutic and research applications. In contrast to oncoretroviral vectors, they are able to infect most nonproliferating cells. In the liver, induction of cell proliferation dramatically
Autor:
Abdullah Ely, Sergio Carmona, Nicolas Ferry, Patricia L. Marion, Patrick Arbuthnot, Marc S. Weinberg, Felix H. Salazar, Carol Crowther, Naazneen Moolla
Publikováno v:
Molecular Therapy. 13(2):411-421
Exploiting the RNA interference pathway has shown promise for developing novel and effective treatment of hepatitis B virus (HBV) infection. To advance this approach, we analyzed the antiviral efficacy of a panel of 10 Pol III U6 promoter-encoded sho
Autor:
Marta Bellodi-Privato, Virginie Pichard, Dominique Aubert, Didier Trono, Tuan Huy Nguyen, Anne Myara, Nicolas Ferry
Publikováno v:
Molecular Therapy. 12(5):852-859
Crigler-Najjar type 1 disease (CN-1) is a genetic disorder characterized by high levels of unconjugated bilirubin due to the absence of hepatic UDPglucuronosyltransferase (UGT1) activity. Here we show that in vivo neonatal hepatocyte transduction wit
Publikováno v:
Human Gene Therapy. 14:473-481
Intravenous delivery of nls-lacZ retroviral vectors to the regenerating liver triggers a cytotoxic immune response directed against transduced hepatocytes. We sought to determine whether prior immunization with retroviral vectors impacted on adeno-as
Publikováno v:
Gene therapy. 22(2)
Chronic infection with hepatitis B virus (HBV) puts individuals at high risk for complicating cirrhosis and liver cancer, but available treatment to counter the virus rarely eliminates infection. Although harnessing RNA interference (RNAi) to silence
Publikováno v:
Cancer Gene Therapy. 8:128-136
Gene transfer of the herpes simplex virus thymidine kinase (HSV-tk) gene sensitizes tumor cells to the toxic effect of ganciclovir (GCV). The toxic effect of GCV extends to nontransduced surrounding cells by a metabolic process known as the bystander
Autor:
Philippe Moullier, Yan Cherel, David Favre, Anna Salvetti, Nicolas Ferry, Nathalie Provost, Véronique Blouin
Publikováno v:
Gene Therapy. 7:1417-1420
Skeletal muscle is a privileged target for long-term rAAV-mediated gene transfer in mouse, rat, dog and non-human primates. Intramuscular injections of rAAV encoding human factor IX in hemophilia B patients have been initiated, based on promising res
Autor:
Dominique Aubert, Philippe Moullier, Olivier Gauthier, Nicolas Ferry, Anne Izembart, Eric Aguado
Publikováno v:
Human Gene Therapy. 10:2917-2925
Gene transfer in regenerating dog liver using high-titer recombinant retroviral vectors carrying the E. coli beta-galactosidase gene was studied. Supernatants containing amphotropic or gibbon ape pseudotyped recombinant retroviruses were infused into
Publikováno v:
Human Gene Therapy. 8:1491-1494
We have used high-titer (10(8) ffu/ml) recombinant retroviral vectors to transfer the beta-galactosidase (beta-Gal) gene to rat hepatocytes in vivo. In animals injected twice in the portal blood stream the next day after partial hepatectomy, half of
Autor:
Piter J. Bosma, Virginie Pichard, Suzanne Duijst, Nicolas Ferry, Dominique Aubert, Paula S. Montenegro-Miranda, L Ten Bloemendaal, D R de Waart
Publikováno v:
Gene therapy, 21(2), 168-174. Nature Publishing Group
Adenoviral (AdV) and Adenovirus-associated viral (AAV) vectors both are used for in vivo gene therapy of inherited liver disorders, such as Crigler-Najjar syndrome type 1. In a relevant animal model, the Gunn rat, both vectors efficiently correct the