Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Meredith McKean"'
Autor:
Meredith McKean, Caressa Lietman
Publikováno v:
Cancer Gene Therapy. 29:1809-1813
Autor:
Sophie Postel-Vinay, Vincent K Lam, Willeke Ros, Todd M Bauer, Aaron R Hansen, Daniel C Cho, F Stephen Hodi, Jan H M Schellens, Jennifer K Litton, Sandrine Aspeslagh, Karen A Autio, Frans L Opdam, Meredith McKean, Neeta Somaiah, Stephane Champiat, Mehmet Altan, Anna Spreafico, Osama Rahma, Elaine M Paul, Christoph M Ahlers, Helen Zhou, Herbert Struemper, Shelby A Gorman, Maura Watmuff, Kaitlin M Yablonski, Niranjan Yanamandra, Michael J Chisamore, Emmett V Schmidt, Axel Hoos, Aurelien Marabelle, Jeffrey S Weber, John V Heymach
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e005301
BackgroundThe phase I first-in-human study ENGAGE-1 evaluated the humanized IgG1 OX40 agonistic monoclonal antibody GSK3174998 alone (Part 1 (P1)) or in combination with pembrolizumab (Part 2 (P2)) in patients with advanced solid tumors.MethodsGSK317
Autor:
Gerald Steven Falchook, Erminia Massarelli, Corey Whalen, Ted Ashburn, Hatem Soliman, Anna Spreafico, Taofeek K. Owonikoko, Robert Wesolowski, Patrick A. Ott, Christopher D. Dupont, John M. Goldberg, Christos Fountzilas, Laura Chow, Igor Puzanov, Julia Auer, Tooba Cheema, Adrienne Yanez, Meredith McKean, Jong Chul Park
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundONCR-177 is a recombinant oncolytic herpes simplex virus (oHSV) that retains γ34.5 and is engineered to express five immunomodulatory transgenes (IL-12, FLT3LG ECD, CCL4 and anti-PD-1 and anti-CTLA-4 antibodies) for the intratumoral treatm
Autor:
Arun Azad, Rui Wang, David Sommerhalder, Tira Tan, Tarek Meniawy, Meredith McKean, Neyssa Marina, Siqing Fu, Giovanni Abbadessa, Hui K Gan, charlotte Lemeque, Helene Pham, Gerald Steven Falchook, Nicole Acuff, Minal A. Barve, Chen Chee, Judy Wang, Jill Mooney
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTHOR-707 (SAR444245) is a recombinant human IL-2 molecule irreversibly bound to a PEG chain to block alpha-binding while retaining near-native affinity for beta/gamma IL-2 receptor subunits. We report updated results from the ongoing HAMMER
Autor:
Justin F. Gainor, Yung Chyung, Shaun M. Cote, Meredith McKean, Lu Gan, Lan Liu, Bruno Bockorny, Timothy A. Yap, Yawen Ju, Sanela Bilic, Michelle Legler, Minal A. Barve
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A563-A563
BackgroundTransforming growth factor-beta 1 (TGFβ1) plays an important role in mediating the primary resistance to PD-1/PD-L1 [PD-(L)1] blockade. SRK-181 is a fully human monoclonal antibody that selectively inhibits latent TGFβ1 activation. Mouse
Autor:
Geoffrey Watson, Meredith McKean, Anthony Tolcher, Anja Victor, Sen Zhang, Vadryn Pierre, Emilia Richter, Aung Naing
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundT cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) is an inhibitory receptor expressed on T cells, including regulatory T cells (Tregs) and natural killer (NK) cells. In the tumor mi