Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kiyoshi Inoguchi"'
Autor:
Motonori Miyakawa, Noriko Yamamoto, Naoya Nagata, Kazuyuki Furuya, Kiyoshi Inoguchi, Seiji Amano, Hiroaki Nejishima
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6310-6313
A rationally designed tetrahydroquinoline (1) for nonsteroidal selective androgen receptor modulators was modified for the exploration of promising compounds by Grieco three-component condensation using various dienophiles. Based on the in vitro effe
Autor:
Tatsuya Maruyama, Satoru Ikegami, Yoichiro Hoshina, Akinori Aoyama, Hideto Fukui, Tsutomu Nakamura, Kiyoshi Inoguchi, Tatsuhiro Harada, Kyoko Fujimoto, Akihiko Okuyama, Hiroshi Tanaka, Yuzuru Matsumura
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(1)
The discovery and SAR of 2,3-diphenylpropionic acid derivatives as highly potent VLA-4 antagonists are described. One representative compound, 9cc has inhibited intercellular adhesion by a VCAM-1/VLA-4 interaction with an IC50 of 1.7 nM, and has good