Zobrazeno 1 - 10
of 10
pro vyhledávání: '"James T. Koerber"'
Autor:
Christopher W. Davies, Angela J. Oh, Rana Mroue, Micah Steffek, John M. Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Uribe, Jake Drummond, Alexandra Frommlet, Cheng Lu, Yvonne Franke, Mark Merchant, Hartmut Koeppen, John G. Quinn, Sushant Malhotra, Steve Do, Lewis Gazzard, Hans E. Purkey, Joachim Rudolph, Melinda M. Mulvihill, James T. Koerber, Weiru Wang, Marie Evangelista
Publikováno v:
Nature Biotechnology. 40:769-778
Small molecules that stabilize inactive protein conformations are an underutilized strategy for drugging dynamic or otherwise intractable proteins. To facilitate the discovery and characterization of such inhibitors, we created a screening platform t
Autor:
Kunal V. Gujraty, David V. Schaffer, James T. Koerber, Sridhar R. Bethi, Ravi S. Kane, Jae Hyung Jang
Publikováno v:
Gene therapy, vol 17, iss 11
Gene therapy
Gene therapy
Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency. Gene delivery technologies capable of mediating l
Publikováno v:
Molecular Therapy. 16:1703-1709
Adeno-associated virus (AAV) vectors are extremely effective gene-delivery vehicles for a broad range of applications. However, the therapeutic efficacy of these and other vectors is currently limited by barriers to safe, efficient gene delivery, inc
Publikováno v:
Nature biotechnology. 31(10)
Aberrant changes in post-translational modifications (PTMs) such as phosphate groups underlie a majority of human diseases. However, detection and quantification of PTMs for diagnostic or biomarker applications often require PTM-specific monoclonal a
Autor:
John G. Flannery, Deniz Dalkara, James T. Koerber, David V. Schaffer, Ryan R. Klimczak, Jae Hyung Jang
The natural tropism of most viral vectors, including adeno-associated viral (AAV) vectors, leads to predominant transduction of neurons and epithelia within the central nervous system (CNS) and retina. Despite the clinical relevance of glia for homeo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf15ce73b4bdeed57e8780a853f85fb6
https://europepmc.org/articles/PMC2788045/
https://europepmc.org/articles/PMC2788045/
Publikováno v:
Human gene therapy. 18(4)
Adeno-associated virus (AAV) is a promising vehicle for gene therapy, which will rely on the generation of high-titer, high-purity recombinant vectors. However, numerous purification protocols can involve challenging optimization or scalability issue
Publikováno v:
Molecular Therapy. 13
Adeno-associated virus (AAV) is a promising vector for human gene delivery that is being explored in clinical trials for cystic fibrosis, Parkinson's Disease, Alzheimer's Disease, and alpha-1-antitrypsin deficiency. However, current purification prot
Publikováno v:
Nature biotechnology. 24(2)
Adeno-associated viral vectors are highly safe and efficient gene delivery vehicles. However, numerous challenges in vector design remain, including neutralizing antibody responses, tissue transport and infection of resistant cell types. Changes must
Publikováno v:
Pharmaceutical research. 21(2)
Polyethylenimine (PEI) is a highly effective gene delivery vector, but because it is an off-the shelf material, its properties may not be optimal. To investigate the effects of the protonation properties of the polymer, we generated PEI derivatives b
Publikováno v:
Molecular Therapy. 11:S418
Adeno-associated viral (AAV) vectors are extremely safe and efficient gene delivery vehicles. However, numerous challenges in vector design remain, including neutralizing antibody responses, tissue transport, and infection of resistant cell types. In