Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jae J. Song"'
Publikováno v:
Molecular therapy oncolytics. 27
Systemic delivery of oncolytic viruses has been widely regarded as an impractical option for antitumor treatment. Here, we selected two target genes as leading components, and significant therapeutic effects were obtained by simultaneously reducing t
Autor:
Jeong A. Hong, Soo Jin Choi, Zhezhu Han, Geun-Hyeok Oh, Yeonsoo Joo, Hye Jin Choi, Ji Hyun Lee, Jae J. Song, Suwan Ko, Rong Xu
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 10, Pp 1-20 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
When the adenoviral protein E1B55K binds death domain-associated protein (Daxx), the proteasome-dependent degradation of Daxx is initiated, and adenoviral replication is effectively maintained. Here, we show that the cellular levels of Daxx differ be
Autor:
Hye Jin Choi, Soo Jin Choi, Dongxu Kang, Geun-Hyeok Oh, Zhezhu Han, Suwan Ko, Suyeon Je, Jihyun Lee, Jae J. Song, Yeonsoo Joo
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-19 (2018)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Transforming growth factor (TGF)-β signaling is increasingly recognized as a key driver in cancer. In progressive cancer tissues, TGF-β promotes tumor formation, and its increased expression often correlates with cancer malignancy. In this study, w
Publikováno v:
Cancer Gene Therapy. 20:82-87
We previously demonstrated that the downregulation of Casitas B-lineage lymphoma (c-Cbl) can sensitize tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in two different ways. One way is to block the rapid degradation
Publikováno v:
Molecular Pharmacology. 62:1409-1417
We observed previously that glucose deprivation induces cytotoxicity, increases the intracellular levels of hydroperoxide, and activates the stress-activated protein kinase (SEK) pathway. In this study, we hypothesized that 1-methylpropyl 2-imidazoly
Publikováno v:
Cancer gene therapy. 20(2)
Tumor cells secrete a variety of cytokines to outgrow and evade host immune surveillance. In this context, transforming growth factor-β1 (TGF-β1) is an extremely interesting cytokine because it has biphasic effects in cancer cells and normal cells.
Autor:
Joo Hang Kim, Eun Ah Cho, Jae J. Song, Eun Hee Kim, Dae Bong Kang, Chae O K Yun, Joohyuk Sohn
Publikováno v:
Human gene therapy. 14(17)
Recombinant adenovirus (Ad) has emerged as the vector system of choice in cancer gene therapy. Its full utility, however, has been limited because of the low efficiency of adenovirus-mediated gene transfer to cancer cells - the main reason being that
Autor:
Jung Young Kim, Chae-Ok Yun, Heuiran Lee, J. H. Kim, E. Kim, Jae J. Song, Jin Woo Chang, Byeong Ha Lee, Joong Uhn Choi
Publikováno v:
Gene therapy. 8(4)
A retroviral vector constructed from the murine leukemia virus (MLV) can only express transgenes in cells undergoing mitosis, indicating its suitability as a delivery vehicle for cancer gene therapy. However, the transduction efficiency (TE) of retro