Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Hiroshi Sugiyama"'
Autor:
Soundhar Ramasamy, Vinodh J. Sahayasheela, Surbhi Sharma, Zutao Yu, Takuya Hidaka, Li Cai, Vaijayanthi Thangavel, Hiroshi Sugiyama, Ganesh N. Pandian
Publikováno v:
ACS Chemical Biology. 17(10):2704-2709
Nanopore direct RNA sequencing (dRNA-Seq) reads reveal RNA modifications through consistent error profiles specific to a modified nucleobase. However, a null data set is required to identify actual RNA modification-associated errors for distinguishin
Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model
Publikováno v:
Cell Chemical Biology. 29(3):463-475
Considering the potential of combinatorial therapies in overcoming existing limitations of cancer immunotherapy, there is an increasing need to identify small-molecule modulators of immune cells capable of augmenting the effect of programmed cell dea
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 25, Iss, Pp 186-197 (2021)
Molecular Therapy: Nucleic Acids, Vol 25, Iss, Pp 186-197 (2021)
In this study, the characteristic patterns of ferroptosis in clear cell renal cell carcinoma (ccRCC) were systematically investigated with the interactions between ferroptosis and the tumor microenvironment (TME). On the mRNA expression profiles of 5
Autor:
Mst. Ayesha Siddika, Takahiro Yamada, Risako Aoyama, Kumi Hidaka, Hiroshi Sugiyama, Masayuki Endo, Shigeyoshi Matsumura, Yoshiya Ikawa
Publikováno v:
Molecules; Volume 27; Issue 23; Pages: 8298
Naturally occurring ribozymes with a modular architecture are promising platforms for construction of RNA nanostructures because modular redesign enables their oligomerization. The resulting RNA nanostructures can exhibit the catalytic function of th
Autor:
Etsuko Yamamoto Hattori, Tatsuya Masuda, Yohei Mineharu, Masamitsu Mikami, Yukinori Terada, Yasuzumi Matsui, Hirohito Kubota, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Tatsutoshi Nakahata, Shuji Ikeda, Susumu Miyamoto, Hiroshi Sugiyama, Yoshiki Arakawa, Yasuhiko Kamikubo
Publikováno v:
Communications Biology. 5
Glioblastoma is the most common adult brain tumour, representing a high degree of malignancy. Transcription factors such as RUNX1 are believed to be involved in the malignancy of glioblastoma. RUNX1 functions as an oncogene or tumour suppressor gene
Publikováno v:
Bioorganic & Medicinal Chemistry. 81:117208
Autor:
Huijuan Mao, Suresh Narva, Xiaoyin Zhao, Yoshimasa Tanaka, Chuanxin Guo, Xuqiong Xiong, Wang Ming, Xudong Ma, Kang Zhou, Wen Zhang, Yanling Wu, Jiachun Liu, Hiroshi Sugiyama
Publikováno v:
Journal of Medicinal Chemistry. 64:6021-6036
In recent years, PD-1 immune checkpoint inhibitors based on monoclonal antibodies have revolutionized cancer therapy, but there still exist unresolved issues, such as the high cost, the relatively low response rates, and so on, compared with small-mo
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(14)
Pyrrole-imidazole polyamides (PIPs) bind to double-stranded DNA (dsDNA) with varied sequence selectivity. We synthesized linear PIPs that can bind to narrow minor grooves of polypurine/polypyrimidine sequences and target long recognition sequences bu
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(12)
Among various kinds of fluorine-substituted biomolecules, 2-fluoroadenine (2FA) and its derivatives have been actively investigated as therapeutic reagents, radio-sensitizers, and
Publikováno v:
ChemBioChem. 22:1538-1545
Pyrrole-imidazole (PI) polyamides, which target specific DNA sequences, have been studied as a class of DNA minor-groove-binding molecules. To investigate the potential of compounds for cancer treatment, PI polyamides were conjugated with DNA-alkylat