Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yinhua Yang"'
Autor:
Robert Burns, Liqin Liu, Yinhua Yang, Haiquan Li, Paul Moore, Jeffrey L. Nordstrom, Sergey Gorlatov, Jonathan Yu-Meng Li
Publikováno v:
Cancer Research. 79:1538-1538
Margetuximab (M) is an investigational Fc-engineered anti-HER2 monoclonal antibody (mAb) with potential for greater immune-mediated anti-tumor activity than trastuzumab (T). M and T bind the same subdomain IV epitope, but M binds with higher affinity
Autor:
Valentina Ciccarone, Jonathan Yu-Meng Li, Jennifer DiChiara, Jim Tamura, Paul Moore, Liqin Liu, Yinhua Yang, Robert Burns, Vatana Long, Ezio Bonvini, Arin Whiddon, Syd Johnson, Qihong Xu, Chia-Ying K Lam, Ling Huang
Publikováno v:
Cancer Research. 79:554-554
Introduction: Trophoblast glycoprotein 5T4 is expressed on the cell surface of multiple cancers yet sparingly on normal adult tissues. CD137 (4-1BB) is a co-stimulatory molecule expressed by activated T and NK cells that support cell activation, prol
Publikováno v:
The EMBO Journal. 17:4647-4656
The mouse amyloid precursor-like protein 2 (APLP2) belongs to the Alzheimer peptide precursor family. A possible role in pre-implantation development had been suggested previously, and was investigated further by creating a large deletion in the geno
Autor:
Kristine Svenson, Ezio Bonvini, Alfredo Darmanin Sheehan, William J.J. Finlay, Paul A. Moore, Jocelyn Sanford, Chad May, Kelvin M. Kerns, Liqin Liu, Susan Benard, Aaron M. D’Antona, Steve Burke, Scott Gatto, Hua Li, Syd Johnson, Hans-Peter Gerber, Yinhua Yang, Edward R. Lavallie, Gurunadh Reddy Chichili, Lioudmila Tchistiakova, Tao He, Peter LaPan, Stephane Olland, William Brady, Khetemenee Lam, Cliona M. O'Sullivan, Wei Cao, Laura Lin, Adam Root, William S. Somers, Bilian Li, Ralph Alderson, Macy Jin, Lisa Racie, Lily Zhu, Weijun Ma, Caryl L. Meade, Lidia Mosyak, Wayne Stochaj, Amy King, Emma Cummins, Matthew Allister Lambert, Laird Bloom, Dianah Barrett, James R. Apgar, Maya Arai
Publikováno v:
Antibodies, Vol 5, Iss 1, p 6 (2016)
Antibodies; Volume 5; Issue 1; Pages: 6
Antibodies
Antibodies; Volume 5; Issue 1; Pages: 6
Antibodies
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART®) bispecific molec
Autor:
Hong-Yu Hu, Si-Tao Yin, Benjamin Chun Yu Wong, Man-Kit Tse, Kong-Hung Sze, Yinhua Yang, Bing Zou, Sin Kam Hui
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 12, p e28511 (2011)
PLoS ONE, Vol 6, Iss 12, p e28511 (2011)
BACKGROUND: Inhibitor of apoptosis proteins (IAPs) belong to a pivotal antiapoptotic protein family that plays a crucial role in tumorigenesis, cancer progression, chemoresistance and poor patient-survival. X-linked inhibitor of apoptosis protein (XI
Autor:
Nadine Tuaillon, Paul A. Moore, Syd Johnson, Wenjun Zhang, Sergey Gorlatov, Valentina Ciccarone, Linda Jin, Stephen P. Burke, Ezio Bonvini, Bhaswati Barat, Weili Wang, Jonah Rainey, Scott Koenig, Yinhua Yang, Hua Li, Ling Huang
Publikováno v:
Journal of molecular biology. 399(3)
Bispecific antibodies capable of redirecting the lytic potential of immune effector cells to kill tumor targets have long been recognized as a potentially potent biological therapeutic intervention. Unfortunately, efforts to produce such molecules ha
Publikováno v:
Journal of molecular biology. 395(5)
Ribosome-inactivating proteins (RIPs) are N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of ribosomal RNA. This modification renders the ribosome unable to bind the elongation factors, thereby inhibiting
Autor:
Yinhua Yang, David M. Valenzuela, Ryan S. Streeper, David B. Lombard, Yaohui Chen, George D. Yancopoulos, Andrew J. Murphy, Sherman M. Weissman, Jakob Bunkenborg, Matthew D. Hirschey, Robert V. Farese, Leonard Guarente, Jennifer Kim, Frederick W. Alt, Marcia C. Haigis, Bjoern Schwer, Roderick T. Bronson, Eric Verdin, Raul Mostoslavsky, Hwei Ling Cheng
Publikováno v:
Lombard, D B, Alt, F W, Cheng, H-L, Bunkenborg, J, Streeper, R S, Mostoslavsky, R, Kim, J, Yancopoulos, G, Valenzuela, D, Murphy, A, Yang, Y, Chen, Y, Hirschey, M D, Bronson, R T, Haigis, M, Guarente, L P, Farese, R V, Weissman, S, Verdin, E & Schwer, B 2007, ' Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation ', Molecular and Cellular Biology, vol. 27, no. 24, pp. 8807-8814 . https://doi.org/10.1128/MCB.01636-07
Udgivelsesdato: 2007-Dec Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307608e1223daa54d3108801d708ee04
https://portal.findresearcher.sdu.dk/da/publications/ceca2130-db42-11dc-860c-000ea68e967b
https://portal.findresearcher.sdu.dk/da/publications/ceca2130-db42-11dc-860c-000ea68e967b
Publikováno v:
International immunology. 16(12)
The consequence of naive CD4+ T cell activation is the differentiation and generation of effector cells. How the engagement of T cell receptors and co-stimulatory receptors leads to profound differential changes is not fully understood. To assess the
Publikováno v:
Experimental cell research. 277(2)
Telomerase is a ribonucleoprotein (RNP) complex that prevents telomeric erosion in eukaryotic cells. Although there are also other associated proteins in this complex, the catalytic activity of this complex is composed of two components. One is a rev