Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ye Chen-Izu"'
Autor:
Yankun Lyu, Phung N. Thai, Lu Ren, Valeriy Timofeyev, Zhong Jian, Seojin Park, Kenneth S. Ginsburg, James Overton, Julie Bossuyt, Donald M. Bers, Ebenezer N. Yamoah, Ye Chen-Izu, Nipavan Chiamvimonvat, Xiao-Dong Zhang
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103624- (2022)
Summary: The mammalian heart beats incessantly with rhythmic mechanical activities generating acids that need to be buffered to maintain a stable intracellular pH (pHi) for normal cardiac function. Even though spatial pHi non-uniformity in cardiomyoc
Externí odkaz:
https://doaj.org/article/71ec355c18ca46c0abb871b3e9983834
Autor:
Katherina M. Alsina, Na Li, Jose L. Puglisi, Donald M. Bers, Xander H.T. Wehrens, Razvan L. Cornea, Hitoshi Uchinoumi, Tetsuro Oda, Ye Chen-Izu, Yi Yang
Publikováno v:
Uchinoumi, H; Yang, Y; Oda, T; Li, N; Alsina, KM; Puglisi, JL; et al.(2016). CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. Journal of Molecular and Cellular Cardiology, 98, 62-72. doi: 10.1016/j.yjmcc.2016.06.007. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9vw6k9jp
© 2016 Elsevier Ltd Diastolic calcium (Ca) leak via cardiac ryanodine receptors (RyR2) can cause arrhythmias and heart failure (HF). Ca/calmodulin (CaM)-dependent kinase II (CaMKII) is upregulated and more active in HF, promoting RyR2-mediated Ca le
Late Na+ current (INaL) significantly contributes to shaping cardiac action potentials (APs) and increased INaL is associated with cardiac arrhythmias. β-adrenergic receptor (βAR) stimulation and its downstream signaling via protein kinase A (PKA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0892744e07603511862a47e584ed5c
Autor:
Rafael Shimkunas, Kenneth S. Ginsburg, Zana Coulibaly, Kit S. Lam, Leighton T. Izu, Julie Bossuyt, Zhong Jian, Bence Hegyi, Ye Chen-Izu, Donald M. Bers
Publikováno v:
Shimkunas, R; Hegyi, B; Jian, Z; Coulibaly, Z; Lam, KS; Ginsburg, KS; et al.(2017). Mechano-chemo-transduction is attenuated in a rabbit model of heart failure. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 112, 147-147. doi: 10.1016/j.yjmcc.2017.07.052. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/59f771b7
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol 112
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol 112
Author(s): Shimkunas, Rafael; Hegyi, Bence; Jian, Zhong; Coulibaly, Zana; Lam, Kit S; Ginsburg, Kenneth S; Bossuyt, Julie; Bers, Donald M; Izu, Leighton T; Chen-Izu, Ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdb6fea7bf5a12b4a27a10c8f09d5ef
http://www.escholarship.org/uc/item/59f771b7
http://www.escholarship.org/uc/item/59f771b7
Autor:
Bence Hegyi, Mónika Gönczi, Norbert Szentandrássy, László Csernoch, Péter P. Nánási, Tamás Bányász, Leighton T. Izu, Ferenc Ruzsnavszky, Kornél Kistamás, Krisztina Váczi, Roland Veress, Ye Chen-Izu, Balázs Horváth, János Magyar
The role of Ca2+-activated Cl- current (ICl(Ca)) in cardiac arrhythmias is still controversial. It can generate delayed afterdepolarizations in Ca2+-overloaded cells while in other studies incidence of early afterdepolarization (EAD) was reduced by I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6642ae770458ec89c88ebdf4894f820
https://escholarship.org/uc/item/7gr8m72p
https://escholarship.org/uc/item/7gr8m72p
Autor:
Ye Chen-Izu
Publikováno v:
Biochemical and Biophysical Research Communications. 391:604-608
In cardiac muscle, Ca2+ entry through the L-type Ca2+ channel during excitation triggers Ca2+ release from sarcoplasmic reticulum (SR) via the ryanodine receptor, causing muscle contraction. This Ca2+ induced Ca2+ release (CICR) is locally controlled
Publikováno v:
Journal of Molecular and Cellular Cardiology. 112:168
Autor:
Takayoshi Kato, Tetsuro Oda, Yi Yang, Takeshi Yamamoto, David D. Thomas, Donald M. Bers, Hitoshi Uchinoumi, Masafumi Yano, Ye Chen-Izu, Razvan L. Cornea
Publikováno v:
Journal of molecular and cellular cardiology. 85
Oxidative stress may contribute to cardiac ryanodine receptor (RyR2) dysfunction in heart failure (HF) and arrhythmias. Altered RyR2 domain-domain interaction (domain unzipping) and calmodulin (CaM) binding affinity are allosterically coupled indices
Autor:
James W. Chan, Wenwu Xiao, Yi-Je Chen, Donald M. Bers, Rafael Shimkunas, John A. Shaw, Yuanpei Li, Ekama Onofiok, Leighton T. Izu, Huilan Han, Tamás Bányász, Tingrui Pan, Nipavan Chiamvimonvat, Zhong Jian, Ye Chen-Izu, Tieqiao Zhang, Jil C. Tardiff, Jose L. Puglisi, Kit S. Lam, Jeffery R. Erickson, Balázs Horváth
Publikováno v:
Science signaling, vol 7, iss 317
Jian, Z; Han, H; Zhang, T; Puglisi, J; Izu, LT; Shaw, JA; et al.(2014). Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Science Signaling, 7(317). doi: 10.1126/scisignal.2005046. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5v76t6qk
Jian, Z; Han, H; Zhang, T; Puglisi, J; Izu, LT; Shaw, JA; et al.(2014). Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Science Signaling, 7(317). doi: 10.1126/scisignal.2005046. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5v76t6qk
Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an afterload during cardiomyocyte contraction, we found that nitric oxide syntha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dac04cd746ef068d5d9791cf16ab43a
https://escholarship.org/uc/item/5v76t6qk
https://escholarship.org/uc/item/5v76t6qk
Autor:
Leighton T. Izu, Kornél Kistamás, Zhong Jian, Ye Chen-Izu, Tamás Bányász, Bence Hegyi, Péter P. Nánási, Balázs Horváth
The objective of this work is to examine the contribution of late Na(+) current (INa,L) to the cardiac action potential (AP) and arrhythmogenic activities. In spite of the rapidly growing interest toward this current, there is no publication availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a4ba44d8f3dde796f42901c4697a67