Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yang Ng"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 582-596 (2021)
Promising progress has been made in adoptive transfer of allogeneic natural killer (NK) cells to treat relapsed or refractory acute myeloid leukemia (AML). In this regard, chimeric antigen receptor (CAR)-modification of NK cells is considered as a co
Autor:
Johan Chin-Kang Tay, Jianqing Zhu, Yu Yang Ng, Yuefang Ren, Chang Zhang, Shu Wang, Zhicheng Du, Xue Hu Xu, Zhendong Li, Junjian Wang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 107-120 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Non-viral platforms can be applied rapidly and cost-effectively for chimeric antigen receptor (CAR)-T cell manufacturing. In the present paper, we describe in detail a clinically relevant manufacturing process for NKG2D CAR-T cells through electropor
Autor:
Yansong Miao, Si Hui Koh, Qianqian Ma, Yuguang Mu, He Sun, Yong-Gui Gao, Justin Tze Yang Ng, Zhu Qiao
Publikováno v:
Journal of Biological Chemistry. 294:18650-18661
Profilins are abundant cytosolic proteins that are universally expressed in eukaryotes and that regulate actin filament elongation by binding to both monomeric actin (G-actin) and formin proteins. The atypical profilin Arabidopsis AtPRF3 has been rep
Autor:
Jinli Wei, Min Wang, Justin Tze Yang Ng, Yingxia Liu, Yang Yang, Xiaochun Wan, Junxin Li, Yi Pan, Konda Mani Saravanan, Tofazzal Hossain, Maoxuan Liu, Yi Shi, Xiaohu Ren, Yanjie Wei, Yin Peng, Haiping Zhang, Huiling Zhang
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008489 (2020)
PLoS Computational Biology
PLoS Computational Biology
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus poses serious threats to the global public health and leads to worldwide crisis. No effective drug or vaccine is readily available. The viral RNA-dependent RNA polymeras
Publikováno v:
Cancer gene therapy. 29(5)
The highly restricted expression of B-cell maturation antigen (BCMA) on plasma cells makes it an ideal target for chimeric antigen receptor (CAR) immune cell therapy against multiple myeloma (MM), a bone marrow cancer. To improve the infiltration of
Autor:
Konda Mani Saravanan, Jinzhi Lin, Jiaxiu Zhou, Haiping Zhang, Yanjie Wei, Justin Tze Yang Ng, Linbu Liao
Publikováno v:
PeerJ
PeerJ, Vol 8, p e8864 (2020)
PeerJ, Vol 8, p e8864 (2020)
Accurate identification of ligand-binding pockets in a protein is important for structure-based drug design. In recent years, several deep learning models were developed to learn important physical–chemical and spatial information to predict ligand
Publikováno v:
Mol Ther
Cytokine-related toxicity associated with the use of highly active chimeric antigen receptor T cells (CAR-T cells) is a significant clinical problem. By fusing the natural killer group 2D (NKG2D) ectodomain to 4-1BB and the DAP12 cytoplasmic domain c
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 1, p 35 (2018)
International Journal of Molecular Sciences
Volume 20
Issue 1
International Journal of Molecular Sciences
Volume 20
Issue 1
Liver sinusoidal endothelial cells (LSECs) represent the permeable interface that segregates the blood compartment from the hepatic cells, regulating hepatic vascular tone and portal pressure amidst changes in the blood flow. In the presence of patho
Publikováno v:
Journal of molecular biology. 430(18 Pt)
The amyloid-beta (Aβ) peptide, commonly found in elevated levels in the brains of patients with Alzheimer's disease (AD) and in the cerebrospinal fluid of individuals presenting mild cognitive impairment, is thought to be one of the major factors re
Publikováno v:
Nature Communications
Two voltage-gated calcium channel subtypes—CaV1.2 and CaV1.3—underlie the major L-type Ca2+ currents in the mammalian central nervous system. Owing to their high sequence homology, the two channel subtypes share similar pharmacological properties