Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wenyu Lin"'
Autor:
Chen Qu, Hao Wang, Shuang Peng, Xue Ning, Jian Hong, Aimin Li, Wenyu Lin, Yue Luo, Peng Chen, Xiaojun Luo, Penghui Xie, Guanqi Dai, Yuchuan Jiang
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 52, Iss 7, Pp 1062-1074 (2020)
Experimental and Molecular Medicine, Vol 52, Iss 7, Pp 1062-1074 (2020)
Dexmedetomidine (DEX) is an anesthetic that is widely used in the clinic, and it has been reported to exhibit paradoxical effects in the progression of multiple solid tumors. In this study, we sought to explore the mechanism by which DEX regulates he
Autor:
Xian Wang, Chao Bi, Liyuan Zhu, Hongchuan Jin, Chao-Qun Wang, Wenyu Lin, Shuzhen Zhang, Qiyin Zhou
Publikováno v:
International Journal of Biological Sciences
Metabolic reprogramming is a hallmark of cancer. Mammalian genome is characterized by pervasive transcription, generating abundant non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are freshly discovered functional ncRNAs exerting extensive re
Autor:
Yongfu Huang, Esperance A. Schaefer, Yongju Zhao, Ming-Lung Yu, Haoju Wang, Zeng Tu, Chuanlong Zhu, Anna Lidofsky, Xiaoqiong Duan, Zhiwen Xu, Raymond T. Chung, Dachuan Cai, Shadi Salloum, Shilin Li, Limin Chen, Jian Hong, Wenyu Lin, Jacinta A. Holmes, Wenting Li, Sae Hwan Lee, Xiao Liu
Publikováno v:
Hepatology. 69:1004-1019
Long noncoding RNAs (lncRNAs) play a critical role in the regulation of many important cellular processes. However, the mechanisms by which lncRNAs regulate viral infection and host immune responses are not well understood. We sought to explore lncRN
Autor:
Raymond T. Chung, Dahlene N. Fusco, Wenyu Lin, Du Cheng, Hong Zhao, Esperance A. Schaefer, Kaku Goto, Niwat Maneekarn, Amornrat O'Brien, Pattranuch Chusri, Lee F. Peng, Lei Zhao, Kattareeya Kumthip, Chansom Pantip, Satawat Thongsawat, Nikolaus Jilg, Leiliang Zhang
Publikováno v:
Journal of Virology. 86:8581-8591
Responses to alpha interferon (IFN-α)-based treatment are dependent on both host and viral factors and vary markedly among patients infected with different hepatitis C virus (HCV) genotypes (GTs). Patients infected with GT3 viruses consistently resp
Autor:
Hong Zhao, Leiliang Zhang, Guoyang Wu, Shaoyong Li, Kattareeya Kumthip, Ethan M. Weinberg, Wen-Chi Chen, Mark A. Brockman, Wenyu Lin, Nikolaus Jilg, Lee F. Peng, Jorge Méndez-Navarro, Detlef Schuppan, Kaku Goto, Raymond T. Chung
Publikováno v:
The Journal of Biological Chemistry
HIV/HCV coinfection leads to accelerated hepatic fibrosis progression, with higher rates of cirrhosis, liver failure, and liver death than does HCV mono-infection. However, the profibrogenic role of HIV on hepatocytes and hepatic stellate cells (HSC)
Publikováno v:
Biotechnology Progress. 26:11-20
The Chinese Hamster Ovary production cell line development process using methotrexate (MTX) amplification is well studied and commonly used for biopharmaceutical processes. However, successful MTX amplification varies from clone to clone and suggeste
Autor:
Qikai Xu, Esperance A. Schaefer, Lei Zhao, Dahlene N. Fusco, Nikolaus Jilg, Xiao Liu, Jian Hong, Chuanlong Zhu, Cynthia Brisac, Lee F. Peng, Raymond T. Chung, Wenyu Lin
Background &/Aims The broadly used antiviral cytokine interferon-α (IFNα)'s mechanisms of action against HCV infection are not well understood. We previously identified SART1, a host protein involved in RNA splicing and pre-mRNA processing, as a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de23f3bdc343f881a10523cea083d8d
https://europepmc.org/articles/PMC4404186/
https://europepmc.org/articles/PMC4404186/
Autor:
Yoichi Hiasa, Raymond T. Chung, Wenyu Lin, Emmett V. Schmidt, Won Hyeok Choe, Yoshitaka Kamegaya, Jason T. Blackard
Publikováno v:
Gastroenterology. 128:1034-1041
Background & Aims: The molecular mechanisms by which hepatitis C virus (HCV) antagonizes the antiviral actions of interferon (IFN) have not been fully characterized. Specifically, how HCV proteins impact on IFN signaling components has yet to be eluc
Autor:
Wenyu Lin, Cynthia Brisac, Lee F. Peng, Sinu P. John, Raymond T. Chung, Yi Wen Huang, Hong Zhao, Abraham L. Brass, Stephane Chevaliez, Daniel Wambua, Dahlene N. Fusco, Christopher R. Chin, Tiao Xie, Leiliang Zhang, Nikolaus Jilg
Background & Aims Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5604b36bb12765982dc1c7486185ae96
https://europepmc.org/articles/PMC3665646/
https://europepmc.org/articles/PMC3665646/
Publikováno v:
Journal of Virology. 69:5734-5742
To explore the role of the CD4 molecule in human immunodeficiency virus (HIV) infection following initial virus-CD4 binding, we have characterized CD4-specific antibodies raised by immunizing an HIV-1-infected human with human recombinant soluble CD4