Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tsutomu Sasaki"'
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 86:509-518
The cluster of differentiation 36 (CD36) is a transmembrane receptor expressed in various cells and has diverse lipid ligands. The expression of CD36 in the murine olfactory epithelium and its ability to recognize certain species of fatty aldehydes,
Autor:
Shigenobu Matsumura, Motoki Miyakita, Haruka Miyamori, Satomi Kyo, Fuka Ishikawa, Tsutomu Sasaki, Tomoki Jinno, Jin Tanaka, Kotomi Fujita, Takumi Yokokawa, Tsuyoshi Goto, Keiko Momma, Shigeo Takenaka, Kazuo Inoue
Publikováno v:
The FASEB Journal. 36
Melanocortin-4 receptor (MC4R) is a critical regulator of appetite and energy expenditure in rodents and humans. MC4R deficiency causes hyperphagia, reduced energy expenditure, and impaired glucose metabolism. Ligand binding to MC4R activates adenyly
Autor:
Tadahiro Kitamura, Kazuko Saeki, Yoshio Fujitani, Tsutomu Sasaki, Hirotaka Watada, Takehiko Yokomizo, Daisuke Kohno, Tomoaki Koga, Takeshi Miyatsuka, Toshiaki Okuno, Saiko Kazuno, Airi Jo-Watanabe, Ayako Fukunaka, Hirotsugu Uzawa
Publikováno v:
The FASEB Journal. 34:13949-13958
Obesity is a health problem worldwide, and brown adipose tissue (BAT) is important for energy expenditure. Here, we explored the role of leukotriene A4 hydrolase (LTA4 H), a key enzyme in the synthesis of the lipid mediator leukotriene B4 (LTB4 ), in
Autor:
Shigeo Takashima, Mayu Suzuki, Tsutomu Sasaki, Hiroshi Takemori, Miwa Maeda, Kentaro Oh-hashi
Publikováno v:
Biochemical and biophysical research communications. 562
Mitochondria are eukaryotic organelles that consist of outer and inner bilayer membranes with a positive potential (H+) in the intermembrane space. This organelle plays an important role in ATP production and apoptosis. To observe the mitochondria in
Autor:
Takayoshi Suga, Daisuke Kohno, Yuichi Ikeuchi, Touko Hirano, Hideru Obinata, Hiromi Yokota-Hashimoto, Eri Wada, Tsutomu Sasaki, Sho Matsui, Masaki Kobayashi, Tadahiro Kitamura, Haruka Tsuneoka, Norikiyo Honzawa, Osamu Kikuchi
Publikováno v:
The Journal of Nutritional Biochemistry. 97:108811
Dysregulation of glucagon is associated with the pathophysiology of type 2 diabetes. We previously reported that postprandial hyperglucagonemia is more obvious than fasting hyperglucagonemia in type 2 diabetes patients. However, which nutrient stimul
Autor:
Eri Wada, Tadahiro Kitamura, Daisuke Kohno, Satoru Kakizaki, Hiromi Yokota-Hashimoto, Kazusane Takeuchi, Osamu Kikuchi, Takayoshi Suga, Sho Matsui, Masaki Kobayashi, Masanobu Yamada, Tsutomu Sasaki
Publikováno v:
Molecular metabolism. 19
Objectives It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of SGLT1 in α cells is also unclear. We aimed to elucidate these points
Autor:
Tsutomu Sasaki, Masato Enari, Shinichi Uesato, Takaaki Sumiyoshi, Suzuho Takemoto, Yu-suke Yamai, Yasuyuki Kawaratani, Kyoji Ishida, Yoshihiro Matsuura, Yoshiyuki Hirata, Saki Matsue
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:1919-1926
Although several p53-Mdm2-binding disruptors have been identified to date, few studies have been published on p53-Mdmx-interaction inhibitors. In the present study, we demonstrated that o-aminothiophenol derivatives with molecular weights of 200-300
Autor:
Ryu Kanzaki, Hiroshi Takemori, Meinoshin Okumura, Naoko Ose, Masato Sanosaka, Soichiro Funaki, Tomohiro Kawamura, Yumi Itoh, Yasushi Shintani, Toru Momozane, Tsutomu Sasaki, Masato Minami
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 96(6)
Carnosol is a naturally occurring herbal compound, known for its antioxidative properties. We previously found that carnosol protected mouse lungs from ischemia–reperfusion injury in ex vivo cultures. To elucidate the molecular mechanisms underpinn
Autor:
Tadahiro Kitamura, Rika Numano, Hiromi Yokota-Hashimoto, Tsutomu Sasaki, Sho Matsui, Naobumi Kimura, Hideyuki Takeuchi
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-15 (2018)
Molecular Brain
Molecular Brain
A high-fat diet (HFD) causes obesity by promoting excessive energy intake, and simultaneously, by disturbing the timing of energy intake. Restoring the feeding pattern is sufficient to prevent HFD-induced obesity in mice. However, the molecular mecha
Autor:
Toshiko Kajita, Tsutomu Sasaki, Tatsuo Ishizuka, Ichiro Mori, Itaru Kojima, Kazuo Kajita, Takayuki Hanamoto, Hideyuki Okada, Takashi Sato, Taro Usui, Tadahiro Kitamura, Yoshihiko Kitada, Koichiro Taguchi, Hiroyuki Morita, Takahide Ikeda
Publikováno v:
FEBS Letters. 588:1935-1941
Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with test