Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Toshiyuki Takehara"'
Autor:
Tatsufumi Mori, Masatsugu Igarashi, Yuta Onodera, Toshiyuki Takehara, Maki Itokazu, Takeshi Teramura
Publikováno v:
Biochemical and Biophysical Research Communications. 651:70-78
Autor:
Kanae Shigi, Kanji Fukuda, Toshiyuki Takehara, Shinichi Nakao, Yuta Onodera, Takatoshi Tsujimoto, Takeshi Teramura, Kei Houri, Tatsufumi Mori
Publikováno v:
Biochemical and Biophysical Research Communications. 523:707-712
Removal of dysfunctional mitochondria is essential step to maintain normal cell physiology, and selective autophagy in mitochondria, called mitophagy, plays a critical role in quality control of mitochondria. While in several diseases and aging, dist
Autor:
Maki Itokazu, Yuta Onodera, Tatsufumi Mori, Shinji Inoue, Kotaro Yamagishi, Akihiro Moritake, Natsumi Iwawaki, Kanae Shigi, Toshiyuki Takehara, Yuji Higashimoto, Masao Akagi, Takeshi Teramura
Publikováno v:
Journal of Biological Chemistry. 298:102098
Sarcopenia is an aging-associated attenuation of muscular volume and strength and is the major cause of frailty and falls in elderly individuals. The number of individuals with sarcopenia is rapidly increasing worldwide; however, little is known abou
Autor:
Hirofumi Suemori, Toshiyuki Takehara, Koichi Suzuki, Koichi Matsuda, Kenji Shinohara, Tatsufumi Mori, Yuji Miyashita, Yasumichi Mieno, Kanji Fukuda, Takeshi Teramura
Publikováno v:
Biochemical and biophysical research communications. 503(4)
Purification of undifferentiated cells by removing differentiated parts is an essential step in pluripotent stem cell culture. This process has been traditionally performed manually using a fine glass capillary or plastic tip under a microscope, or b
Autor:
Akane Kizu, Kohei Kitada, Shoji Fukushima, Masayasu Koyama, Daisuke Tachibana, Toshiyuki Takehara, Hideki Wanibuchi, Takashi Morita, Kayo Yoshida, Masami Hayashi, Takeshi Teramura
Publikováno v:
Environmental Science and Pollution Research. 22:18252-18259
A high-throughput test of cell growth inhibition was performed using mouse embryonic stem (ES) cells to assess chemical toxicities. We herein demonstrated using a 96-well culture plate approach and the MTT assay that this method was suitable for prio
Autor:
Takuro Horii, Merissa Olmer, Toshiyuki Takehara, Hiroshi Asahara, Takeshi Teramura, Izuho Hatada, Yuta Onodera, Kanji Fukuda, Martin Lotz, Joe Hasei, Toshifumi Ozaki
Publikováno v:
Scientific Reports
The objective was to investigate the levels of TWIST1 in normal and OA cartilage and examine its role in regulating gene expression in chondrocytes. Human cartilage tissues and chondrocytes were obtained at autopsy from normal knee joints and from OA
Autor:
Toshiyuki Takehara, Takeshi Teramura, Chiaki Hamanishi, Koichi Nakagawa, Yuta Onodera, Kanji Fukuda
Publikováno v:
Biochemical and Biophysical Research Communications. 417:836-841
Mechanical stimulation has been shown to regulate the proliferation and differentiation of stem cells. However, the effects of the mechanical stress on the stemness or related molecular mechanisms have not been well determined. Pluripotent stem cells
Autor:
Makoto Takenoshita, Toshiyuki Takehara, Kanji Fukuda, Yuta Onodera, Yoshihiko Hosoi, Takeshi Teramura, Naoto Fukunaga, Norimasa Sagawa, Ryo Kakegawa
Publikováno v:
Molecular Human Reproduction
Non-human primates are suitable models for preclinical research aimed at cell-replacement therapies. Recently, it has been reported that Rho-associated kinase inhibitor Y-27632 markedly reduced dissociation-induced apoptosis of human embryonic stem (
Publikováno v:
Scientific Reports
The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand
Autor:
Norimasa Sagawa, Yuta Onodera, Toshiyuki Takehara, Yoshihiko Hosoi, Madoka Ozawa, Chiaki Hamanishi, Kanji Fukuda, Tasuku Mitani, Masayuki Anzai, Takeshi Teramura
Publikováno v:
Theriogenology. 74(1)
Recent studies have illustrated multiple differentiation potentials of embryonic stem cells (ESCs), derived from parthenogenetic embryos, to various kinds of cells (all three embryonic germ layers). However, differentiation diversity of the parthenog