Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Toshihide Nishimura"'
Autor:
Taiken, Sakano, Ai Saiga, Egusa, Yoko, Kawauchi, Jiawei, Wu, Toshihide, Nishimura, Nobuhiro, Nakao, Ayumu, Kuramoto, Takumi, Kawashima, Shigenobu, Shiotani, Yukio, Okada, Kenichiro, Sato, Nobuya, Yanai
Publikováno v:
Bioscience, Biotechnology, and Biochemistry.
Imidazole dipeptides (ID) are abundant in skeletal muscle and the brain and have various functions, such as antioxidant, pH-buffering, metal-ion chelation. However, the physiological significance of ID has not been fully elucidated. In this study, we
Autor:
Hiroyuki Kimura, Saeko Naruki, Toshihide Nishimura, György Marko-Varga, Masayuki Takagi, Hiroki Sakai, Tomoyuki Miyazawa, Kiyonaga Fujii, Harubumi Kato, Hisashi Saji, Haruhiko Nakamura, Naoki Furuya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
No therapeutic targets have been identified for lung squamous cell cancer (SqCC) which is the second most prevalent lung cancer because its molecular profiles remain unclear. This study aimed to unveil disease-related protein networks by proteomic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa1c9bec483ad7f8260474d7932c153
https://doi.org/10.21203/rs.3.rs-798490/v1
https://doi.org/10.21203/rs.3.rs-798490/v1
Autor:
Masayuki Takagi, Kien Thiam Tan, Saeko Naruki, Shu-Jen Chen, Harubumi Kato, Hisashi Saji, Kiyonaga Fujii, Hirotaka Koizumi, Toshihide Nishimura, Haruhiko Nakamura, De-Wei Zhuo, Yasufumi Kato, Naoki Furuya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
The tumourigenesis of early lung adenocarcinomas, including adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and lepidic predominant invasive adenocarcinoma (LPA), remains unclear. This study aimed to capture disease-related mol
Autor:
Ákos Végvári, György Marko-Varga, Hisashi Saji, Haruhiko Nakamura, Toshihide Nishimura, Naoki Furuya
Publikováno v:
Expert review of proteomics. 16(9)
Introduction: Lung cancer is the leading cause of cancer death worldwide. Proteogenomics, a way to integrate genomics, transcriptomics, and proteomics, have emerged as a way to understand molecular causes in cancer tumorigenesis. This understanding w
Autor:
Yuka Miyata, Masahiro Hoshikawa, Tomoyuki Miyazawa, Hisashi Saji, Hiroki Sakai, Kouhei Tsumoto, Saeko Naruki, Hiroko Hata, Haruhiko Nakamura, Masayuki Takagi, Hirotaka Koizumu, Ikuya Takahashi, Vipul Gupta, Kiyonaga Fujii, Toshihide Nishimura
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0217105 (2019)
PLoS ONE, Vol 14, Iss 6, p e0217105 (2019)
Small-cell lung carcinoma (SCLC) and large-cell neuroendocrine lung carcinoma (LCNEC) are high-grade lung neuroendocrine tumors (NET). However, comparative protein expression within SCLC and LCNEC remains unclear. Here, protein expression profiles we
Autor:
Tatsuhiko Kodama, Tetsuya Fukuda, Toshihide Nishimura, Hiroshi Hike, Takeshi Kawamura, Yasuhiko Bando, Fumihiko Usui
Publikováno v:
Analytical Biochemistry. 486:14-16
Highly protonated histone-derived peptides impede a sufficient mass spectrometry (MS)-based epigenetic analysis because their relatively low m/z, due to a high degree of proton addition to peptides, would make it difficult to analyze the resulting co
Publikováno v:
Expert review of proteomics. 14(4)
Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease.
Autor:
Toshihide Nishimura, Yasufumi Kato, Yasuhiko Bando, Toshitaka Nagao, Thomas E. Fehniger, György Marko-Varga, Masaharu Nomura, Tetsuya Fukuda, Kiyonaga Fujii, Harubumi Kato, Haruhiko Nakamura, Hiromasa Tojo
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176219 (2017)
PLoS ONE
PLoS ONE
Selected reaction monitoring mass spectrometry (SRM-MS) -based semi-quantitation was performed to assess the validity of 46 selected candidate proteins for specifically diagnosing large-cell neuroendocrine lung carcinoma (LCNEC) and differentiating i
Autor:
Christian Ingvar, Göran Jönsson, Melinda Rezeli, Toshihide Nishimura, Charlotte Welinder, Thomas Laurell, Elisabet Wieslander, Bo Jansson, Håkan Olsson, Thomas Breslin, Thomas E. Fehniger, Bo Baldetorp, Ákos Végvári, Yutaka Sugihara, György Marko-Varga, Lotta Lundgren
Publikováno v:
PROTEOMICS. 14:1963-1970
Malignant melanoma (MM) patients are being treated with an increasing number of personalized medicine (PM) drugs, several of which are small molecule drugs developed to treat patients with specific disease genotypes and phenotypes. In particular, the
Autor:
György Marko-Varga, Masaharu Nomura, Norihiko Ikeda, Toshihide Nishimura, Yasufumi Kato, Makoto Kihara, Harubumi Kato
Publikováno v:
International Journal of Proteomics
An overview on targeted personalized medicine is given describing the developments in Japan of lung cancer patients. These new targeted therapies with novel personalized medicine drugs require new implementations, in order to follow and monitor drug