Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Timo K. van den Berg"'
Autor:
Martin de Boer, Floris P. J. van Alphen, Martijn van der Kuip, Taco W. Kuijpers, Hans Janssen, Suzanne W.J. Terheggen, Karin van Leeuwen, Timo K. van den Berg, Judy Geissler, Alexander B. Meijer, Dirk Roos, Esther de Vries
Publikováno v:
Human Mutation. 38:1402-1411
Hermansky-Pudlak syndrome type 2 (HPS2) is a syndrome caused by mutations in the beta-3A subunit of the adaptor protein (AP)-3 complex (AP3B1 gene). We describe five unreported cases with four novel mutations, one of which caused aberrant pre-mRNA sp
Autor:
Thomas M. van Gulik, Barbara Dierdorp, Jesper Kers, Christine W. Bruggeman, Joke M. M. den Haan, René Lutter, Timo K. van den Berg, Julia H E Houtzager, Robin van Bruggen, Taco W. Kuijpers, Steven T. Pals
Publikováno v:
Bruggeman, C W, Houtzager, J, Dierdorp, B, Kers, J, Pals, S T, Lutter, R, van Gulik, T, den Haan, J M M, van den Berg, T K, van Bruggen, R & Kuijpers, T W 2019, ' Tissue-specific expression of IgG receptors by human macrophages ex vivo ', PLoS ONE, vol. 14, no. 10, e0223264 . https://doi.org/10.1371/journal.pone.0223264
PLoS ONE, 14(10):e0223264. Public Library of Science
PLoS ONE, Vol 14, Iss 10, p e0223264 (2019)
PLoS ONE
PLoS ONE, 14(10):e0223264. Public Library of Science
PLoS ONE, Vol 14, Iss 10, p e0223264 (2019)
PLoS ONE
Recently it was discovered that tissue-resident macrophages derive from embryonic precursors, not only from peripheral blood monocytes, and maintain themselves by self-renewal. Most in-vitro studies on macrophage biology make use of in-vitro cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b5dcfd9cea5836e8327e79f09a5bec
https://doi.org/10.1371/journal.pone.0223264
https://doi.org/10.1371/journal.pone.0223264
Autor:
Christine W. Bruggeman, Sietse Q. Nagelkerke, Joke M. M. den Haan, Robin van Bruggen, Erik Mul, Taco W. Kuijpers, Timo K. van den Berg
Publikováno v:
Blood advances, 2(8), 941-953. American Society of Hematology
Nagelkerke, S Q, Bruggeman, C W, den Haan, J M M, Mul, E P J, van den Berg, T K, van Bruggen, R & Kuijpers, T W 2018, ' Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors ', BLOOD ADVANCES, vol. 2, no. 8, pp. 941-953 . https://doi.org/10.1182/bloodadvances.2017015008, https://doi.org/10.1182/bloodadvances.2017015008
BLOOD ADVANCES, 2(8), 941-953. American Society of Hematology
Nagelkerke, S Q, Bruggeman, C W, den Haan, J M M, Mul, E P J, van den Berg, T K, van Bruggen, R & Kuijpers, T W 2018, ' Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors ', BLOOD ADVANCES, vol. 2, no. 8, pp. 941-953 . https://doi.org/10.1182/bloodadvances.2017015008, https://doi.org/10.1182/bloodadvances.2017015008
BLOOD ADVANCES, 2(8), 941-953. American Society of Hematology
Tissue-resident macrophages in the spleen play a major role in the clearance of immunoglobulin G (IgG)-opsonized blood cells, as occurs in immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Blood cells are phagocytosed via the Fc-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8ec1c4f847cb71ce7cb91bb81423dd
https://europepmc.org/articles/PMC5916003/
https://europepmc.org/articles/PMC5916003/
Autor:
Eva M. Janssen-Megens, Myrto Kostadima, Marta Gut, Farzin Pourfarzad, Sebastian Ullrich, Mattia Frontini, Luigi Grassi, Daniel Rico, Ida H. Hiemstra, Alfonso Valencia, Ehsan Habibi, Juliane Perner, Anton T.J. Tool, Hinri Kerstens, Angelika Merkel, Ivo Gut, Paul Flicek, Erik Mul, Taco W. Kuijpers, Ernesto Lowy, Enrique Carrillo-de-Santa-Pau, Joost H.A. Martens, Kim Berentsen, Laura Clarke, Marie-Laure Yaspo, Timo K. van den Berg, Willem H. Ouwehand, Avik Datta, Guoqiang Yi, Hendrik G. Stunnenberg, Dirk Roos, Martin Vingron, Matthias Linser, Simon Heath, Felipe Were
Publikováno v:
Cell reports
Cell reports, 24(10), 2784-2794. Cell Press
Cell Reports, 24(10), 2784-2794. Cell Press
Cell Reports, 24, 10, pp. 2784-2794
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cell Reports, 24, 2784-2794
Cell Reports
Grassi, L, Pourfarzad, F, Ullrich, S, Merkel, A, Were, F, Carrillo-de-Santa-Pau, E, Yi, G, Hiemstra, I H, Tool, A T J, Mul, E, Perner, J, Janssen-Megens, E, Berentsen, K, Kerstens, H, Habibi, E, Gut, M, Yaspo, M L, Linser, M, Lowy, E, Datta, A, Clarke, L, Flicek, P, Vingron, M, Roos, D, van den Berg, T K, Heath, S, Rico, D, Frontini, M, Kostadima, M, Gut, I, Valencia, A, Ouwehand, W H, Stunnenberg, H G, Martens, J H A & Kuijpers, T W 2018, ' Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils ', Cell Reports, vol. 24, no. 10, pp. 2784-2794 . https://doi.org/10.1016/j.celrep.2018.08.018
Cell Reports, Vol 24, Iss 10, Pp 2784-2794 (2018)
Cell reports, 24(10), 2784-2794. Cell Press
Cell Reports, 24(10), 2784-2794. Cell Press
Cell Reports, 24, 10, pp. 2784-2794
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cell Reports, 24, 2784-2794
Cell Reports
Grassi, L, Pourfarzad, F, Ullrich, S, Merkel, A, Were, F, Carrillo-de-Santa-Pau, E, Yi, G, Hiemstra, I H, Tool, A T J, Mul, E, Perner, J, Janssen-Megens, E, Berentsen, K, Kerstens, H, Habibi, E, Gut, M, Yaspo, M L, Linser, M, Lowy, E, Datta, A, Clarke, L, Flicek, P, Vingron, M, Roos, D, van den Berg, T K, Heath, S, Rico, D, Frontini, M, Kostadima, M, Gut, I, Valencia, A, Ouwehand, W H, Stunnenberg, H G, Martens, J H A & Kuijpers, T W 2018, ' Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils ', Cell Reports, vol. 24, no. 10, pp. 2784-2794 . https://doi.org/10.1016/j.celrep.2018.08.018
Cell Reports, Vol 24, Iss 10, Pp 2784-2794 (2018)
Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features o
Autor:
Manfred Wuhrer, Suzanne N. Lissenberg-Thunnissen, Christine W. Bruggeman, Gestur Vidarsson, Louise W. Treffers, Sietse Q. Nagelkerke, Theo Rispens, Arthur E. H. Bentlage, Timo K. van den Berg, Gillian Dekkers, Taco W. Kuijpers, Carolien A. M. Koeleman
Publikováno v:
Journal of immunology (Baltimore, Md., 199(1), 204-211. American Association of Immunologists
Bruggeman, C W, Dekkers, G, Bentlage, A E H, Treffers, L W, Nagelkerke, S Q, Lissenberg-Thunnissen, S, Koeleman, C A M, Wuhrer, M, van den Berg, T K, Rispens, T, Vidarsson, G & Kuijpers, T W 2017, ' Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile ', Journal of Immunology, vol. 199, no. 1, pp. 204-211 . https://doi.org/10.4049/jimmunol.1700116
Journal of Immunology, 199(1), 204-211. American Association of Immunologists
Journal of Immunology, 199(1), 204-211
Bruggeman, C W, Dekkers, G, Bentlage, A E H, Treffers, L W, Nagelkerke, S Q, Lissenberg-Thunnissen, S, Koeleman, C A M, Wuhrer, M, van den Berg, T K, Rispens, T, Vidarsson, G & Kuijpers, T W 2017, ' Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile ', Journal of Immunology, vol. 199, no. 1, pp. 204-211 . https://doi.org/10.4049/jimmunol.1700116
Journal of Immunology, 199(1), 204-211. American Association of Immunologists
Journal of Immunology, 199(1), 204-211
Abs of the IgG isotype are glycosylated in their Fc domain at a conserved asparagine at position 297. Removal of the core fucose of this glycan greatly increases the affinity for FcγRIII, resulting in enhanced FcγRIII-mediated effector functions. N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b47bcccf99c2e634625077d63554f1
https://pure.amc.nl/en/publications/enhanced-effector-functions-due-to-antibody-defucosylation-depend-on-the-effector-cell-fc-receptor-profile(42124375-c194-410c-8f31-02dfaa46076f).html
https://pure.amc.nl/en/publications/enhanced-effector-functions-due-to-antibody-defucosylation-depend-on-the-effector-cell-fc-receptor-profile(42124375-c194-410c-8f31-02dfaa46076f).html
Autor:
Rob van Zwieten, Elena Kostova, Boukje M. Beuger, Martijn Veldthuis, Timo K. van den Berg, Emile van den Akker, Robin van Bruggen, Ingrid Kühnle, Jutte van der Werff ten Bosch
Publikováno v:
Kostova, E B, Beuger, B M, Veldthuis, M, van der Werff Ten Bosch, J, Kühnle, I, van den Akker, E, van den Berg, T K, van Zwieten, R & van Bruggen, R 2015, ' Intrinsic defects in erythroid cells from familial hemophagocytic lymphohistiocytosis type 5 patients identify a role for STXBP2/Munc18-2 in erythropoiesis and phospholipid scrambling ', Experimental Hematology, vol. 43, no. 12, pp. 1072-1076.e2 . https://doi.org/10.1016/j.exphem.2015.08.007
Experimental Hematology, 43(12), 1072-1076.e2. Elsevier Inc.
Experimental hematology, 43(12), 1072-1076. Elsevier Inc.
Experimental Hematology, 43(12), 1072-1076.e2. Elsevier Inc.
Experimental hematology, 43(12), 1072-1076. Elsevier Inc.
Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is a rare genetic disorder caused by mutations in STXBP2/Munc18-2. Munc18-2 plays a role in the degranulation machinery of natural killer cells and cytotoxic T lymphocytes. Mutations in STXBP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db82022f1b59f2fd913da4ae3cc9d7c
https://doi.org/10.1016/j.exphem.2015.08.007
https://doi.org/10.1016/j.exphem.2015.08.007
Autor:
Timo K. van den Berg, Elena Kostova, Robin van Bruggen, Pasi Halonen, Thomas R. L. Klei, Boukje M. Beuger, Cor Lieftink, Roderick L. Beijersbergen
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 35, Iss 2, p e00187 (2015)
Kostova, E B, Beuger, B M, Klei, T R L, Halonen, P, Lieftink, C, Beijersbergen, R, van den Berg, T K & van Bruggen, R 2015, ' Identification of signalling cascades involved in red blood cell shrinkage and vesiculation ', Frontiers in Bioscience, vol. 35, no. 2 . https://doi.org/10.1042/BSR20150019
Frontiers in Bioscience, 35(2). Frontiers in Bioscience
Bioscience reports, 35(2). Portland Press Ltd.
Bioscience Reports, Vol 35, Iss 2, p e00187 (2015)
Kostova, E B, Beuger, B M, Klei, T R L, Halonen, P, Lieftink, C, Beijersbergen, R, van den Berg, T K & van Bruggen, R 2015, ' Identification of signalling cascades involved in red blood cell shrinkage and vesiculation ', Frontiers in Bioscience, vol. 35, no. 2 . https://doi.org/10.1042/BSR20150019
Frontiers in Bioscience, 35(2). Frontiers in Bioscience
Bioscience reports, 35(2). Portland Press Ltd.
Even though red blood cell (RBC) vesiculation is a well-documented phenomenon, notably in the context of RBC aging and blood transfusion, the exact signalling pathways and kinases involved in this process remain largely unknown. We have established a
Autor:
Iris M. De Cuyper, Vishal Salunkhe, Laura Gutierrez, Timo K. van den Berg, Mark Hoogenboezem, Maaike R. Scheenstra, Eveline Li, Taco W. Kuijpers
Publikováno v:
Blood cells, molecules & diseases, 55(4), 293-303. Academic Press Inc.
Scheenstra, M R, Salunkhe, V, De Cuyper, I M, Hoogenboezem, M, Li, E, Kuijpers, T W, van den Berg, T K & Gutiérrez, L 2015, ' Characterization of hematopoietic GATA transcription factor expression in mouse and human dendritic cells ', Blood Cells Molecules and Diseases, vol. 55, no. 4, pp. 293-303 . https://doi.org/10.1016/j.bcmd.2015.07.006
Blood Cells Molecules and Diseases, 55(4), 293-303. Academic Press Inc.
Scheenstra, M R, Salunkhe, V, De Cuyper, I M, Hoogenboezem, M, Li, E, Kuijpers, T W, van den Berg, T K & Gutiérrez, L 2015, ' Characterization of hematopoietic GATA transcription factor expression in mouse and human dendritic cells ', Blood Cells Molecules and Diseases, vol. 55, no. 4, pp. 293-303 . https://doi.org/10.1016/j.bcmd.2015.07.006
Blood Cells Molecules and Diseases, 55(4), 293-303. Academic Press Inc.
Dendritic cells (DCs) are key initiators and regulators of the immune response. The development of the DC lineage and their subsets requires an orchestrated regulation of their transcriptional program. Gata1, a transcription factor expressed in sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31c921edea8281f3b52b38bfe4a6306
https://pure.amc.nl/en/publications/characterization-of-hematopoietic-gata-transcription-factor-expression-in-mouse-and-human-dendritic-cells(ed1abc84-3fa9-48c9-87e1-47652ff23144).html
https://pure.amc.nl/en/publications/characterization-of-hematopoietic-gata-transcription-factor-expression-in-mouse-and-human-dendritic-cells(ed1abc84-3fa9-48c9-87e1-47652ff23144).html
Autor:
Jacqueline Alblas, Christine D. Dijkstra, Chantal Renardel de Lavalette, Timo K. van den Berg, Marion H. Brown, Henk Honing
Publikováno v:
Alblas, J, Honing, H, de Lavalette, C R, Brown, M H, Dijkstra, C D & van den Berg, T K 2005, ' Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT-and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways ', Molecular and Cellular Biology, vol. 25, no. 16, pp. 7181-7192 . https://doi.org/10.1128/MCB.25.16.7181-7192.2005
Molecular and Cellular Biology, 25(16), 7181-7192
Molecular and cellular biology, 25(16), 7181-7192. American Society for Microbiology
Molecular and Cellular Biology, 25(16), 7181-7192
Molecular and cellular biology, 25(16), 7181-7192. American Society for Microbiology
Signal regulatory protein alpha (SIRPalpha) is a glycoprotein receptor that recruits and signals via the tyrosine phosphatases SHP-1 and SHP-2. In macrophages SIRPalpha can negatively regulate the phagocytosis of host cells and the production of tumo
Autor:
Jonas Heilskov Graversen, Mette Madsen, Søren K. Moestrup, Christian Jacobsen, Holger Jon Møller, Timo K. van den Berg, Marianne Jensby Nielsen
Publikováno v:
Journal of Biological Chemistry. 279:51561-51567
CD163 is the macrophage receptor for endocytosis of haptoglobin.hemoglobin complexes. The extracellular region consisting of nine scavenger receptor cysteine rich (SRCR) domains also circulates in plasma as a soluble protein. By ligand binding analys