Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Scott M. Smith"'
Autor:
Julia E. Stroud, Michael S. Gale, Sara R. Zwart, Martina Heer, Scott M. Smith, Tony Montina, Gerlinde AS Metz
Publikováno v:
Cellular and Molecular Life Sciences. 79
Spaceflight entails a variety of environmental and psychological stressors that may have long-term physiological and genomic consequences. Metabolomics, an approach that investigates the terminal metabolites of complex physiological alterations, take
Autor:
Thomas H. Mader, Scott M. Smith, Charles Robert Gibson, Steven H. Zeisel, Sara R. Zwart, Jesse F. Gregory, Patrick J. Stover
Publikováno v:
The FASEB Journal. 31:3746-3756
During and after missions on the International Space Station, some astronauts experience ophthalmic changes, including choroidal folds, optic disc edema, cotton-wool spots, globe flattening, and refraction changes. Astronauts with ophthalmic issues h
Autor:
Jeffery M. Klco, Benjamin J. Ainscough, Katie M. Campbell, Vincent Magrini, Malachi Griffith, Jason Walker, Nicholas C. Spies, John F. DiPersio, Peter Westervelt, David E. Larson, Sharon Heath, Jin Zhang, Catrina Fronick, Jasreet Hundal, Elaine R. Mardis, Shelly O'Laughlin, Timothy J. Ley, Sean McGrath, Christopher G. Maher, Christopher A. Miller, Kilannin Krysiak, Robert Lesurf, Timothy A. Graubert, Matthew J. Christopher, Robert S. Fulton, Daniel C. Link, Jacqueline E. Payton, James M. Eldred, Alex H. Wagner, Zachary L. Skidmore, Tamara Lamprecht, Avinash Ramu, Rick K. Wilson, Scott M. Smith, Matthew J. Walter, Obi L. Griffith, Shashikant Kulkarni
Publikováno v:
Experimental Hematology. 44:603-613
The genomic events responsible for the pathogenesis of relapsed adult B-lymphoblastic leukemia (B-ALL) are not yet clear. We performed integrative analysis of whole-genome, whole-exome, custom capture, whole-transcriptome (RNA-seq), and locus-specifi
Autor:
Jesse F. Gregory, Jason M. Kinchen, Sara R. Zwart, Per Magne Ueland, Scott M. Smith, Robert Ploutz-Snyder, Thomas H. Mader, Charles Robert Gibson, Steven H. Zeisel, Martina Heer
Publikováno v:
The FASEB Journal. 30:141-148
Ophthalmic changes have occurred in a subset of astronauts on International Space Station missions. Visual deterioration is considered the greatest human health risk of spaceflight. Affected astronauts exhibit higher concentrations of 1-carbon metabo
Autor:
Gabriel E. Sanderson, William E. Schroeder, Chris Harris, Gary Stiehr, Lynn K. Carmichael, Benjamin J. Ainscough, Shawn Leonard, Charles Lu, Ian T. Ferguson, James M. Eldred, Nathaniel G. Nutter, Amy Hawkins, Eric M. Clark, Allison A. Regier, Thomas P. Mooney, Todd Wylie, Elaine R. Mardis, Michael D. McLellan, Michael J. Kiwala, Malachi Griffith, Ken Chen, Joshua F. McMichael, Kyung H. Kim, Travis E. Abbott, Robert T. L. Long, Benjamin S. Abbott, Edward A. Belter, Indraniel Das, Richard W. Wohlstadter, Adam F. Dukes, Matthew B. Callaway, Feiyu Du, Vincent Magrini, Jason Walker, Benjamin J. Oberkfell, Nicole Maher, Zachary L. Skidmore, Cyriac Kandoth, Scott M. Smith, Christopher A. Miller, Jasreet Hundal, Xian Fan, David L. Morton, Todd G. Hepler, Brian R. Derickson, Christopher G. Maher, David J. Dooling, Craig Pohl, David E. Larson, James V. Weible, Xiaoqi Shi, Joshua Peck, Matthew R. Weil, Justin T. Lolofie, Adam C. Coffman, Nathan D. Dees, Li Ding, Anthony M. Brummett, Mark M. Burnett, William Schierding, Avinash Ramu, Richard K. Wilson, Obi L. Griffith, Daniel C. Koboldt
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 7, p e1004274 (2015)
PLoS Computational Biology
PLoS Computational Biology
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides detailed tracking of samples and data coupled
Publikováno v:
The FASEB Journal. 29
Mitigating space flight-induced bone loss is critical for space exploration, and diet can play a major role in this effort. Previous ground-based studies provide evidence that dietary composition can influence bone resorption during bed rest. In this
Autor:
Thomas H. Mader, Charles Robert Gibson, Jesse F. Gregory, Jason M. Kinchen, Steven H. Zeisel, Per Magne Ueland, Robert Ploutz-Snyder, Sara R. Zwart, Scott M. Smith
Publikováno v:
The FASEB Journal. 29
Intermediates of the one-carbon metabolic pathway are altered in astronauts who experience vision-related issues during and after space flight. Serum concentrations of homocysteine, cystathionine, 2-methylcitric acid, and methylmalonic acid were high
Autor:
Nancy D. Turner, Sara R. Zwart, Scott M. Smith, Honglu Wu, Corey A. Theriot, Jennifer L. L. Morgan, Lauren E. Ritchie, Clarence Sams, Brian Crucian
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(3)
Astronauts are exposed to increased body iron stores and radiation, both of which can cause oxidative damage leading to negative health effects. The purpose of this study was to investigate combined effects of high dietary iron (650 mg/kg diet) and r
Publikováno v:
The FASEB Journal. 27
Autor:
Kimberly O. O'Brien, Carmen Casteneda Sceppa, Meryl E. Wastney, Steven A. Abrams, PL Gillman, Scott M. Smith, Sara R. Zwart
Publikováno v:
The FASEB Journal. 27
To assess the potential for artificial gravity (AG) and exercise (EX) to mitigate the effects of bone loss during space flight, we performed two studies: (1) a 21-d bed rest (BR) with subjects rece...