Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Robert Rottapel"'
Autor:
Yoshinori Matsumoto, Robert Rottapel
Publikováno v:
Trends in Molecular Medicine. 29:390-405
Modification of proteins by ADP-ribose (PARsylation) is catalyzed by the poly(ADP-ribose) polymerase (PARP) family of enzymes exemplified by PARP1, which controls chromatin organization and DNA repair. Additionally, PARsylation induces ubiquitylation
Autor:
Mohamed A. Soliman, Gerald D. Gish, Monika Tucholska, Rick Bagshaw, Sasha A. Doodnauth, Marilyn S Hsiung, Melany J. Wagner, Robert Rottapel, Claus Jørgensen
Publikováno v:
J Biol Chem
Eph receptors are a family of receptor tyrosine kinases that control directional cell movement during various biological processes, including embryogenesis, neuronal pathfinding, and tumor formation. The biochemical pathways of Eph receptors are cont
Autor:
Christopher B. Marshall, Jose La Rose, Marc Balan, Mitsuhiko Ikura, Wei Xu, Anne-Claude Gingras, Robert Rottapel, Deborah K. Morrison, Amber L. Couzens, María-José Sandí, Noboru Ishiyama, Daniel M. Monson, Etienne Coyaud, Brian Raught, Arun A. Chandrakumar, Ming Zhou
Publikováno v:
Science signaling. 10(503)
The PAR-1-MARK pathway controls cell polarity through the phosphorylation of microtubule-associated proteins. The Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which activates the ras homolog family member A (RHOA), is anchored to the micro
Activating KRAS mutations are nearly ubiquitous in pancreatic cancer occurring in more than 95% of clinical cases. miRNAs are small noncoding RNAs that regulate gene expression by binding sequences within the 3′UTRs of target mRNAs. An integral rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2232d57d2beeb244b1cd22e9d03eb8
https://europepmc.org/articles/PMC4794362/
https://europepmc.org/articles/PMC4794362/
Autor:
Mitsuhiko Ikura, Matthew J. Smith, Christopher B. Marshall, Vuk Stambolic, Robert Rottapel, Geneviève M.C. Gasmi-Seabrook, Mohammad T. Mazhab-Jafari, David Meiri
Publikováno v:
Methods. 57:473-485
The Ras superfamily of small GTPases is a large family of switch-like proteins that control diverse cellular functions, and their deregulation is associated with multiple disease processes. When bound to GTP they adopt a conformation that interacts w
Autor:
Melissa A. Greeve, Chuanjin Wu, Mitsuhiko Ikura, David Meiri, Marc Balan, Christopher B. Marshall, Bryan Kim, Fernando Suarez, Chris Bakal, Robert Rottapel, Noah Fine, Jose LaRose
Publikováno v:
Molecular Cell. 45:642-655
Summary Actin-based stress fiber formation is coupled to microtubule depolymerization through the local activation of RhoA. While the RhoGEF Lfc has been implicated in this cytoskeleton coupling process, it has remained elusive how Lfc is recruited t
The Mitotic Spindle Orientation Factor Lfc/Arhgef2 is Essential for Hematopoietic Stem Cell Function
Autor:
Robert Rottapel, Carl D. Novina, María José Sandí, Cailin E. Joyce, Kristin J Hope, Ana Vujovic, Nicholas Wong, Derek C K Chan, Jose La Rose, Laura P.M.H. de Rooij
Publikováno v:
Experimental Hematology. 64:S41
Autor:
Dina Finan, Robert Rottapel, Andrea Brunet, Melissa A. Greeve, Jose LaRose, Clark D. Wells, David Meiri
Publikováno v:
Molecular and Cellular Biology. 29:5963-5973
Lfc is a guanine nucleotide exchange factor (GEF) for Rho that demonstrates an unusual ability to associate with microtubules. While several phosphorylated residues have been detected in the Lfc polypeptide, the mechanism(s) by which phosphorylation
Autor:
Subburaj Ilangumaran, Gina M. Doody, Wen-Chen Yeh, Grace Chen, Ioannis D. Dimitriou, Jennifer L. Gommerman, Robert Rottapel, Martin R Turner, Jose La Rose
Publikováno v:
Molecular and Cellular Biology. 27:3109-3122
3BP2 is a pleckstrin homology domain- and Src homology 2 (SH2) domain-containing adapter protein that is mutated in the rare human bone disorder cherubism and which has also been implicated in immunoreceptor signaling. However, a function for this pr
Autor:
Bradley J. Sedgmen, Oliver Utting, David Lohnes, André Veillette, Xiaoshu Shi, Angelo Iulianella, Robert Rottapel, Tania H. Watts
Publikováno v:
Molecular and Cellular Biology. 24:6067-6075
The SLP-76 family of immune cell-specific adaptors is composed of three distinct members named SLP-76, Blnk, and Clnk. They have been implicated in the signaling pathways coupled to immunoreceptors such as the antigen receptors and Fc receptors. Prev