Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rima Al-awar"'
Autor:
Matthew J. Varney, Wouter Steyaert, Paul J. Coucke, Joris R. Delanghe, David E. Uehling, Babu Joseph, Richard Marcellus, Rima Al-awar, Jeffrey L. Benovic
Publikováno v:
Journal of Biological Chemistry, 298
JOURNAL OF BIOLOGICAL CHEMISTRY
Journal of Biological Chemistry, 298, 10
JOURNAL OF BIOLOGICAL CHEMISTRY
Journal of Biological Chemistry, 298, 10
Recent studies identified a missense mutation in the gene coding for G protein???coupled receptor kinase 6 (GRK6) that segregates with type 2 diabetes (T2D). To better understand how GRK6 might be involved in T2D, we used pharmacological inhibition a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51382fdf8c1f2aaac07fadd21161983
http://hdl.handle.net/2066/285325
http://hdl.handle.net/2066/285325
Autor:
Michael Prakesch, Rima Al-awar, Ahmed Aman, Pierre Maisonneuve, Lauren Caldwell, Derek F. Ceccarelli, Ganna Posternak, Theo Goullet de Rugy, Mikko Taipale, Igor Kurinov, Julia Kitaygorodsky, Pavel Mader, Karen Colwill, Gennady Poda, Brett Larsen, Anne-Claude Gingras, Kin Chan, Jeff Wrana, Ting Jin, Salima Daou, Marc Therrien, Stephen Orlicky, Hugo Lavoie, Daniel Durocher, Xiaojing Tang, Cassandra J. Wong, Frank Sicheri, David Uehling, Robert A. Batey, Zhe Yin, Stefan Maier
Publikováno v:
Nat Chem Biol
The RAF family kinases function in the RAS-ERK pathway to transmit signals from activated RAS to the downstream kinases MEK and ERK. This pathway regulates cell proliferation, differentiation and survival, enabling mutations in RAS and RAF to act as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d3e2daaba5123ff078df9ce3f29cce
https://europepmc.org/articles/PMC7862923/
https://europepmc.org/articles/PMC7862923/
Autor:
Gennady Poda, Marko Jakopović, Levon Halabelian, Methvin Isaac, Nikolina Radulovich, Michael Prakesch, Caroline Huard, Ahmed Aman, Dhananjay Joshi, Zhong Yao, Manuel Chan, Wiebke Schormann, Richard Marcellus, Babu Joseph, Rima Al-awar, Luka Drecun, Mohammed Mohammed, Li Niu, Brigitte L. Thériault, María Sánchez-Osuna, David Uehling, Ahmed Mamai, Ming-Sound Tsao, Jasmin Coulombe-Huntington, Taira Kiyota, Evelyne Lima-Fernandes, Punit Saraon, Ankit Rai, Jamie Snider, David W. Andrews, Cheryl H. Arrowsmith, Farzaneh Aboualizadeh, Natasha B. Leighl, Miroslav Samaržija, Victoria Wong, Anna Lyakisheva, Mike Tyers, Ratheesh Subramanian, Adrian G. Sacher, Fengling Li, Masoud Vedadi, Igor Stagljar, Shivanthy Pathmanathan
Publikováno v:
Journal of Molecular Biology. 433:167294
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are effective at inhibiting mutant EGFR N
Autor:
Rima Al-awar, David Uehling, Babu Joseph, Sheng Li, Jose M. Paredes, Tatyana Mamonova, Angel Orte, Kunhong Xiao, W. Bruce Sneddon, Qiangmin Zhang, Peter A. Friedman, Jennifer McGarvey, Hongda Liu, Frederic Jean-Alphonse, Dawei Wang
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (12), pp.4546-4571. ⟨10.1074/jbc.RA119.007421⟩
Journal of Biological Chemistry 12 (294), 4546-4571. (2019)
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (12), pp.4546-4571. ⟨10.1074/jbc.RA119.007421⟩
Journal of Biological Chemistry 12 (294), 4546-4571. (2019)
International audience; Na+-H+ exchanger regulatory factor-1 (NHERF1) is a PDZ protein that scaffolds membrane proteins, including sodium-phosphate co-transport protein 2A (NPT2A) at the plasma membrane. NHERF1 is a phosphoprotein with 40 Ser and Thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b17dad0646bc6ce03f297a21ee2571
https://hal.inrae.fr/hal-02628955
https://hal.inrae.fr/hal-02628955
Autor:
Carmen Coxon, Charline Giroud, James M. Bennett, Carina Gileadi, Gennady Poda, Rima Al-awar, Thomas Christott, Vicki Gamble, Oleg Fedorov, Viktor Beke, Octovia P. Monteiro, Suet Ling Felce, Gillian Farnie
Publikováno v:
Slas Discovery.
Eleven-nineteen leukemia (ENL) contains an epigenetic reader domain (YEATS domain) that recognizes lysine acylation on histone 3 and facilitates transcription initiation and elongation through its interactions with the super elongation complex (SEC)
Publikováno v:
Biochemical Journal
We identified five structurally different compounds that trigger the pro-apoptotic protein Bax to permeabilize mitochondrial outer membranes leading to cellular demise. The molecular mechanisms by which these compounds and pro-apoptotic BH3 proteins
Autor:
Michael Prakesch, Ahmed Aman, Victoria Wong, Leanne E Wybenga-Groot, Michael F. Moran, Nika Vučković, Adrian G. Sacher, Luka Drecun, Miroslav Samaržija, Alessandro Datti, Nhu-An Pham, Zhong Yao, Gennady Poda, Punit Saraon, Marko Jakopović, Babu Joseph, Jenny Wang, Konstantin Weiss, Nikolina Radulovich, Anna Akhmanova, Jin H Park, Adriana Vučetić, Anna Lyakisheva, Ming-Sound Tsao, Ankit Rai, David Uehling, Farzaneh Aboualizadeh, Jamie Snider, Natasha B. Leighl, Frances A. Shepherd, Richard Marcellus, Rima Al-awar, Igor Stagljar, Yannis Kalaidzidis, Brigitte L. Thériault, Marino Zerial, Shivanthy Pathmanathan, Yuhui Wang
Publikováno v:
Nature Chemical Biology, 16(5), 577. Nature Publishing Group
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays. Due to frequent development of drug res
Autor:
Keiryn L. Bennett, Kilian Huber, Roberto Avellino, Anna Skucha, Giulio Superti-Furga, Andreas Schönegger, Florian Grebien, Aiping Dong, Dalia Barsyte-Lovejoy, Fengling Li, David Smil, Richard Marcellus, Matthäus Getlik, Peter Brown, Guillermo Senisterra, Johannes Zuber, Amit Grover, Ekaterina Kuznetsova, Hong Wu, Cheryl H. Arrowsmith, Gennadiy Poda, Ruud Delwel, Martin Bilban, Alexey Stukalov, Sarah Vittori, Masoud Vedadi, Christoph Bock, Rima Al-awar, Matthieu Schapira, Claus Nerlov, Roberto Giambruno
Publikováno v:
Nature chemical biology
Nature Chemical Biology, 11(8), 571-U122. Nature Publishing Group
Nature Chemical Biology, 11(8), 571-U122. Nature Publishing Group
The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective expression of a short (30-kDa) CCAAT-enhancer binding protein-alpha (C/EBP alpha) translational isoform, termed p30, represents the most common type of CEBPA mut
Autor:
Abdellah Allali-Hassani, Marius Sudol, Amber L. Couzens, Menno J. Oudhoff, Hong Zeng, Peter Brown, Masoud Vedadi, Mitchell J.S. Braam, Aiping Dong, Anne-Claude Gingras, Brian S. Gerstenberger, Fengling Li, Richard Marcellus, Spencer A. Freeman, Fabio M.V. Rossi, Dafydd R. Owen, Rima Al-awar, Lee R. Roberts, Tatlock John H, Hong Wu, Paul V. Fish, Steven Kennedy, Ahmed Aman, Colby Zaph, Guillermo A. Senisterra, Matthieu Schapira, Jean-Philippe Lambert, Ekaterina Kuznetsova, Cheryl H. Arrowsmith, Mark E. Bunnage, Rachel L. Grimley, Dalia Barsyte-Lovejoy, Caroline L. Benn
Publikováno v:
Proceedings of the National Academy of Sciences. 111:12853-12858
SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported substrates. Here, we report the discovery of (R)-PFI-2-a first-in-class, potent (Ki (app) =
Autor:
Melanie Spears, Rima Al-awar, Jms Bartlett, Paul M. Krzyzanowski, Linda Liao, Nicola Lyttle, M Braunstein, Richard Marcellus, K. J. Taylor, Irina Kalatskaya, Lincoln Stein
Publikováno v:
Cancer Research. 73:P5-08
Drug resistance in breast cancer is the major obstacle to a successful outcome following chemotherapy treatment. While a well-recognized mechanism of resistance involves upregulation of multidrug resistance (MDR) genes, the complexity and hierarchy o