Zobrazeno 1 - 10
of 28 132
pro vyhledávání: '"RNA Interference"'
Autor:
Yongjian Guo, Liang Wang, Zhen Qi, Yu Liu, Kun Tian, Huanran Qiang, Pei Wang, Guohua Zhou, Xiaobo Zhang, Shu Xu
Publikováno v:
RNA Biology. 19:1172-1178
No current RNA-targeted interference tools have been reported to simultaneously up and down-regulate different gene expressions. Here we characterized an RNA-targeted genetic regulatory strategy composed of a flap endonuclease 1 (FEN1) and specific m
Autor:
Kristijonas Žemaitis, Agatheeswaran Subramaniam, Roman Galeev, Aurel Prosz, Maria Jassinskaja, Jenny Hansson, Jonas Larsson
Publikováno v:
Experimental Hematology. 115:20-29
The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs) to screen for modifier
Autor:
Astrid D. Haase
Publikováno v:
RNA Biology. 19:1094-1102
PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a small RNA-based adaptive immune system that restricts the deleterious activity of mobile genetic elements to protect genome integrity. Self/nonself discrimination is at th
Autor:
Jose H Arteaga, Jorma Hinkula, Edvard C.I Smith, Britta Wahren, Abdalla J. Mohamed, Maria E. Cardona, Kristin Gustafsson, Birger Christensson
Publikováno v:
Molecular Biology Reports. 49:11187-11192
Treatment with RNAi against HIV-1 transcripts efficiently inhibits viral replication but induces selection of escape mutants; therefore, the CCR5 coreceptor was suggested as an additional target. Blocking viral and host transcripts improved the antiv
Autor:
Izhar Ullah, Ehab A. R. Kamel, Syed Tanveer Shah, Abdul Basit, Heba I. Mohamed, Muhammad Sajid
Publikováno v:
Molecular Biology Reports. 49:10975-10993
Due to the rising population globally, and the demand for food, it is critical to significantly increase crop production by 2050. However, climate change estimates show that droughts and heatwaves will become more prevalent in many parts of the world
Autor:
Junyu Luo, Jichao Ji, Jinjie Cui, Li Dongyang, Xiangzhen Zhu, Hui Xue, Xueke Gao, Zhang Kaixin, Li Wang, Lin Niu, Peng Zhao
Publikováno v:
International Journal of Biological Macromolecules. 194:895-902
Cytochrome P450 monooxygenase (P450 or CYP) plays an important role in the metabolism of insecticides and plant allelochemicals by insects. CYP321B1, a novel Spodoptera litura P450 gene, was identified and characterized. CYP321B1 contains a 1488 bp o
Autor:
Qi Tang, Jacquelyn Sousa, Dimas Echeverria, Xueli Fan, Ying-Chao Hsueh, Khashayar Afshari, Nicholas MeHugh, David A. Cooper, Lorenc Vangjeli, Kathryn Monopoli, Ken Okamura, Annabelle Biscans, Adam Clauss, John E. Harris, Anastasia Khvorova
Publikováno v:
Molecular Therapy. 30:2709-2721
Aberrant activation of interferon (IFN)-γ signaling plays a key role in several autoimmune skin diseases, including lupus erythematosus, alopecia areata, vitiligo, and lichen planus. Here, we identify fully chemically modified small interfering RNAs
Publikováno v:
Nucleic Acid Therapeutics. 32:321-332
Double-stranded RNAs (dsRNAs) longer than 30 bp have not been considered desirable RNA interference (RNAi) triggering structures in mammalian cells as they nonspecifically activate innate immune response. However, in earlier studies, not only dsRNA l
Autor:
Shuai, Tan, Guilin, Li, Hengjun, Guo, Han, Li, Ming, Tian, Qingxin, Liu, Ying, Wang, Baohua, Xu, Xingqi, Guo
Publikováno v:
Insect Molecular Biology. 31:634-646
Cuticular proteins (CPs) are known to play important roles in insect development and defence responses. The loss of CP genes can lead to changes in insect morphology and sensitivity to the external environment. In this study, we identified the AccCPR
Autor:
Lucas Henrique Figueiredo Prates, Maximilian Merlau, Johanna Rühl-Teichner, Marc F. Schetelig, Irina Häcker
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9266
Double-stranded RNA (dsRNA) can trigger RNA interference (RNAi) and lead to directed silencing of specific genes. This natural defense mechanism and RNA-based products have been explored for their potential as a sustainable and ecofriendly alternativ