Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pranav Danthi"'
Publikováno v:
J Virol
Viral antagonism of innate immune pathways is a common mechanism by which viruses evade immune surveillance. Infection of host cells with reovirus leads to the blockade of NF-{kappa}B, a key transcriptional regulator of the hosts innate immune respon
Successful initiation of infection by many different viruses requires their uptake into the endosomal compartment. While some viruses exit this compartment early, others must reach the degradative, acidic environment of the late endosome. Mammalian o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63adbd5cf2d5588b34faf9a01fb9bca4
https://doi.org/10.1101/2021.09.26.461887
https://doi.org/10.1101/2021.09.26.461887
Autor:
Anthony J. Snyder, Pranav Danthi
Publikováno v:
Journal of Biological Chemistry. 291:26773-26785
Virus-host interactions play a role in many stages of the viral lifecycle, including entry. Reovirus, a model system for studying the entry mechanisms of nonenveloped viruses, undergoes a series of regulated structural transitions that culminate in d
Autor:
Pranav Danthi, Payel Sarkar
Publikováno v:
Journal of Virology. 87:13532-13542
The reovirus outer capsid protein μ1 forms a lattice surrounding the viral core. In the native state, μ1 determines the environmental stability of the viral capsid. Additionally, during cell entry, μ1 undergoes structural rearrangements that facil
Autor:
Joshua D. Doyle, Terence S. Dermody, Emily A. Kendall, Laura S. Ooms, Pranav Danthi, J. Denise Wetzel
Publikováno v:
Journal of Biological Chemistry. 287:8029-8038
Following attachment and internalization, mammalian reoviruses undergo intracellular proteolytic disassembly followed by viral penetration into the cytoplasm. The initiating event in reovirus disassembly is the cathepsin-mediated proteolytic degradat
Autor:
Payel Sarkar, Pranav Danthi
Publikováno v:
Journal of Virology. 84:12723-12732
Cell entry of reovirus requires a series of ordered steps, which include conformational changes in outer capsid protein μ1 and its autocleavage. The μ1N fragment released as a consequence of these events interacts with host cell membranes and media
Autor:
J. Denise Wetzel, James D. Chappell, Geoffrey H. Holm, Gregory J. Wilson, Kristen M. Guglielmi, Wesley B. Skelton, Melissa S. Maginnis, Elizabeth M. Johnson, Terence S. Dermody, Sam Naik, Pranav Danthi, Karl W. Boehme, Elizabeth A. Eby, Takeshi Kobayashi, Annukka A.R. Antar
Publikováno v:
Cell Host & Microbe. 1:147-157
Mammalian orthoreoviruses (reoviruses) are highly tractable experimental models for studies of double-stranded (ds) RNA virus replication and pathogenesis. Reoviruses infect respiratory and intestinal epithelium and disseminate systemically in newbor
Autor:
Pia Arrate, Terence S. Dermody, Pranav Danthi, Dean W. Ballard, Mark W. Hansberger, Kenneth B. Marcu, Kevin N. Pennington, Jacquelyn A. Campbell
Publikováno v:
Journal of Virology. 81:1360-1371
Reoviruses induce apoptosis both in cultured cells and in vivo. Apoptosis plays a major role in the pathogenesis of reovirus encephalitis and myocarditis in infected mice. Reovirus-induced apoptosis is dependent on the activation of transcription fac
Autor:
Mark W. Hansberger, Terence S. Dermody, Pranav Danthi, Jacquelyn A. Campbell, J. Craig Forrest
Publikováno v:
Journal of Virology
Apoptosis plays a major role in the cytopathic effect induced by reovirus following infection of cultured cells and newborn mice. Strain-specific differences in the capacity of reovirus to induce apoptosis segregate with the S1 and M2 gene segments,
Publikováno v:
Journal of Molecular Biology. 296:335-340
When poliovirus attaches to its receptor or is heated in hypotonic buffers, the virion undergoes an irreversible conformational transition from the native 160 S (or N) particle to the 135 S (or A) particle, which is believed to mediate cell entry. Th