Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrick Rabe"'
Autor:
Philip Hinchliffe, Karina Calvopiña, Patrick Rabe, Maria F. Mojica, Christopher J. Schofield, Gary I. Dmitrienko, Robert A. Bonomo, Alejandro J. Vila, James Spencer
Publikováno v:
Journal of Biological Chemistry. 299:104606
Autor:
Patrick Rabe, Carla C. Walla, Noelle K. Goodyear, Jordan Welsh, Rebecca Southwart, Ian Clifton, James D.S. Linyard, Anthony Tumber, Tim D.W. Claridge, William K. Myers, Christopher J. Schofield
Publikováno v:
The Journal of biological chemistry. 298(9)
Isopenicillin N synthase (IPNS) catalyzes formation of the β-lactam and thiazolidine rings of isopenicillin N from its linear tripeptide l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) substrate in an iron- and dioxygen (O
Autor:
Xiao Liu, Raphael Reinbold, Shuang Liu, Ryan A. Herold, Patrick Rabe, Stéphanie Duclos, Rahul B. Yadav, Martine I. Abboud, Sandrine Thieffine, Fraser A. Armstrong, Lennart Brewitz, Christopher J. Schofield
Publikováno v:
Journal of Biological Chemistry. 299:102873
Variants of isocitrate dehydrogenase (IDH) 1 and 2 (IDH1/2) alter metabolism in cancer cells by catalyzing the NADPH-dependent reduction of 2-oxoglutate (2OG) to (2R)-hydroxyglutarate (2HG). However, it is unclear how derivatives of 2OG can affect ca
Publikováno v:
ChemBioChem. 17:1333-1337
The EI-MS fragmentation mechanism of the bacterial sesquiterpene epi-isozizaene was investigated through enzymatic conversion of all 15 synthetic ((13) C1 )FPP isotopomers with the epi-isozizaene synthase from Streptomyces albus and GC-MS and GC-QTOF
Publikováno v:
ChemBioChem. 17:146-149
The biosynthesis of corvol ethers A and B, two sesquiterpenes from Kitasatospora setae, proceeds with involvement of either one 1,3- or two sequential 1,2-hydride shifts. Quantum chemical calculations revealed that the sequence of two 1,2-hydride shi
Autor:
Christian A. Citron, Patrick Rabe, Michael Groll, Carina C. de Oliveira Mann, Jeroen S. Dickschat, Norman Kaufmann, Philipp Baer
Publikováno v:
ChemBioChem. 15:213-216
The biosynthesis of terpenes is catalysed by class I and II terpene cyclases. Here we present structural data from a class I hedycaryol synthase in complex with nerolidol, serving as a surrogate for the reaction intermediate nerolidyl diphosphate. Th
Publikováno v:
ChemBioChem. 14:2345-2354
The volatile terpenes of 24 actinomycetes whose genomes have been sequenced (or are currently being sequenced) were collected by use of a closed-loop stripping apparatus and identified by GC/MS. The analytical data were compared against a phylogeneti