Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nahum Puebla-Osorio"'
Publikováno v:
Diabetes. 62:2429-2438
The genesis of β-cells predominantly occurs through self-replication; therefore, understanding the regulation of cell proliferation is essential. We previously showed that the lack of nonhomologous end joining (NHEJ) DNA repair factor ligase IV lead
Publikováno v:
Oncogene. 29:957-965
V(D)J recombination is essential for the maturation of lymphocytes. Because of the involvement of cutting and joining DNA double strands, this recombination activity is strictly contained within the noncycling phases of the cell cycle. Such containme
Publikováno v:
The Journal of Experimental Medicine
Tumor suppressor p53-dependent apoptosis is critical in suppressing tumorigenesis. Previously, we reported that DNA double-strand breaks (DSBs) at the V(D)J recombination loci induced genomic instability in the developing lymphocytes of nonhomologous
Publikováno v:
The Journal of investigative dermatology
Ultraviolet (UV) radiation-induced systemic immune suppression is a major risk factor for skin cancer induction. The migration of dermal mast cells from the skin to the draining lymph nodes plays a prominent role in activating systemic immune suppres
Autor:
Shaoying Li, Qing Ma, Nahum Puebla-Osorio, Kimberly Schluns, Jeong Soo Kim, Huiyuan Zhang, Chengming Zhu, Sandra S. Ojeda, Omid Tavana, Yu Wang
Publikováno v:
Oncogene. 33(21)
Ku70, a known nonhomologous end-joining (NHEJ) factor, also functions in tumor suppression, although this molecular mechanism remains uncharacterized. Previously, we showed that mice deficient for DNA ligase IV (Lig4), another key NHEJ factor, succum
Autor:
Stephen E. Ullrich, Nahum Puebla-Osorio, Omid Tavana, Cara L. Benjamin, Honnavara N. Ananthaswamy, Chengming Zhu, Mei Sang
Genotoxic stress triggers the p53 tumor suppressor network to activate cellular responses that lead to cell cycle arrest, DNA repair, apoptosis or senescence. This network functions mainly through transactivation of different downstream targets, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7abb8faf55a8ceb0598ac248b7f28d
https://europepmc.org/articles/PMC3041166/
https://europepmc.org/articles/PMC3041166/
Publikováno v:
Molecular and cellular biology. 26(10)
DNA ligases catalyze the joining of strand breaks in the phosphodiester backbone of duplex DNA and play essential roles in DNA replication, recombination, repair, and maintenance of genomic integrity. Three mammalian DNA ligase genes have been identi
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 138(4)
The halogenated aromatic hydrocarbon 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to induce immunotoxicity, but relatively little is known regarding its effects on B-lymphocytes, and on avian B-cells in particular. In this study, the avian bur