Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Michal Goldberg"'
Autor:
Michael Milyavsky, Lital Eini, Shlomit Ezer, Eran Meshorer, Ayala Gold, Rotem Hanania, Michal Goldberg, Ruth Viner, Malka Nissim-Rafinia, Keren Erez, Nasma Aqaqe
Publikováno v:
Oncogene. 38:3103-3118
The cancer stem cell (CSC) model suggests that a subpopulation of cells within the tumor, the CSCs, is responsible for cancer relapse and metastasis formation. CSCs hold unique characteristics, such as self-renewal, differentiation abilities, and res
Publikováno v:
Cell Division, Vol 14, Iss 1, Pp 1-13 (2019)
Cell Division
Cell Division
Background Cell cycle regulation is a complex system consisting of growth-promoting and growth-restricting mechanisms, whose coordinated activity is vital for proper division and propagation. Alterations in this regulation may lead to uncontrolled pr
Publikováno v:
Journal of Biological Chemistry. 287:36488-36498
The first step in V(D)J recombination is the formation of specific DNA double-strand breaks (DSBs) by the RAG1 and RAG2 proteins, which form the RAG recombinase. DSBs activate a complex network of proteins termed the DNA damage response (DDR). A key
APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair
Autor:
Michal Goldberg, Arnon Nagler, Reuben S. Harris, Ori Cheshin, Leah Baraz, Ofer I. Wilner, Moshe Kotler, Itamar Willner, Elena Britan-Rosich, Roni Nowarski, Or David Shahar, Edan Kenig
Publikováno v:
Blood. 120:366-375
APOBEC3 proteins catalyze deamination of cytidines in single-stranded DNA (ssDNA), providing innate protection against retroviral replication by inducing deleterious dC > dU hypermutation of replication intermediates. APOBEC3G expression is induced i
Autor:
Barbara Mlody, James Adjaye, Tomer Halevy, Martina Bohndorf, Nissim Benvenisty, Shira Akov, Michal Goldberg
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2499-2511 (2016)
SummaryNijmegen breakage syndrome (NBS) results from the absence of the NBS1 protein, responsible for detection of DNA double-strand breaks (DSBs). NBS is characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition.
Publikováno v:
Oncogene. 31:3495-3504
DNA double-strand breaks (DSBs), the most hazardous DNA lesions, may result in genomic instability, a hallmark of cancer cells. The main DSB repair pathways are non-homologous end joining (NHEJ) and homologous recombination (HR). In mammalian cells,
Autor:
Carmit Strauss, Michal Goldberg
Publikováno v:
Cell Cycle. 10:2850-2857
DNA double-strand breaks (DSBs) are the most severe type of DNA damage. Occurrence of DSBs in the cell activates the DNA damage response (DDR), which involves signaling cascades that sense and respond to the damage. Promptly after DSB induction, DDR
Autor:
Carmit Strauss, Zvi Hayouka, Gideon Coster, Assaf Friedler, Liron Argaman, Michael Brandeis, Michal Goldberg
Publikováno v:
Journal of Biological Chemistry. 282:32053-32064
MDC1 (NFBD1), a mediator of the cellular response to DNA damage, plays an important role in checkpoint activation and DNA repair. Here we identified a cross-talk between the DNA damage response and cell cycle regulation. We discovered that MDC1 binds
Publikováno v:
Journal of Cell Science. 120:77-85
The intimate association between nuclear lamins and chromatin is thought to regulate higher order chromatin organization. Previous studies have mapped a region between the rod domain and the Ig fold in the tail domain of Drosophila melanogaster lamin
Autor:
Michal Goldberg
Genomic DNA is continuously damaged by external and endogenous factors, resulting in diverse DNA lesions. Impairment in responding to these lesions may result in genomic instability and trigger tumorigenesis. Luckily, cells have evolved the DNA damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe608026340f95af4ccee7a1998ae91c
https://europepmc.org/articles/PMC4612111/
https://europepmc.org/articles/PMC4612111/