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pro vyhledávání: '"Michael P. Meers"'
Autor:
Carrie Myers, Steven J. Wu, Michael P. Meers, James M. Olson, Derek H. Janssens, Kami Ahmad, Steven Henikoff, Jay F. Sarthy
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-14 (2018)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background Our understanding of eukaryotic gene regulation is limited by the complexity of protein–DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. We recently introduced CUT&R
Publikováno v:
Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-11 (2019)
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-11 (2019)
Background CUT&RUN is an efficient epigenome profiling method that identifies sites of DNA binding protein enrichment genome-wide with high signal to noise and low sequencing requirements. Currently, the analysis of CUT&RUN data is complicated by its
Publikováno v:
Mol Cell
Summary Although the in vitro structural and in vivo spatial characteristics of transcription factor (TF) binding are well defined, TF interactions with chromatin and other companion TFs during development are poorly understood. To analyze such inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8e071527fd0a1d8bb3937b33601348
https://europepmc.org/articles/PMC6697550/
https://europepmc.org/articles/PMC6697550/
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Previously, we described a novel alternative to chromatin immunoprecipitation, CUT&RUN, in which unfixed permeabilized cells are incubated with antibody, followed by binding of a protein A-Micrococcal Nuclease (pA/MNase) fusion protein (Skene and Hen
Publikováno v:
RNA (New York, N.Y.). 19(11)
Reduced levels of survival motor neuron (SMN) protein lead to a neuromuscular disease called spinal muscular atrophy (SMA). Animal models of SMA recapitulate many aspects of the human disease, including locomotion and viability defects, but have thus
Autor:
Daniel J. McKay, Kaitlin P. Curry, A. Gregory Matera, Brian D. Strahl, Taylor J.R. Penke, Robert J. Duronio, Michael P. Meers, Pamela Y. Malek, Jason D. Lieb, Stephen L. McDaniel, Stephen W. Cooper, Stephen Klusza, Deirdre C. Tatomer
Publikováno v:
Developmental Cell. (3):373-386
SummaryHistones and their posttranslational modifications influence the regulation of many DNA-dependent processes. Although an essential role for histone-modifying enzymes in these processes is well established, defining the specific contribution of