Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Michael J. Welsh"'
Autor:
Tayyab Rehman, Philip H. Karp, Andrew L. Thurman, Steven E. Mather, Akansha Jain, Ashley L. Cooney, Patrick L. Sinn, Alejandro A. Pezzulo, Michael E. Duffey, Michael J. Welsh
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:491-502
In cystic fibrosis (CF), reduced HCOsub3/subsup-/supsecretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pHsubASL/sub) in CF may help identify novel targets and faci
Autor:
Andrew L. Thurman, Xiaopeng Li, Raul Villacreses, Wenjie Yu, Huiyu Gong, Steven E. Mather, Guillermo S. Romano-Ibarra, David K. Meyerholz, David A. Stoltz, Michael J. Welsh, Ian M. Thornell, Joseph Zabner, Alejandro A. Pezzulo
Publikováno v:
American journal of respiratory cell and molecular biology. 66(6)
Lack of CFTR (cystic fibrosis transmembrane conductance regulator) affects the transcriptome, composition, and function of large and small airway epithelia in people with advanced cystic fibrosis (CF); however, whether lack of CFTR causes cell-intrin
Publikováno v:
Developmental cell. 57(18)
Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory capacity linked to vagal neurons and immune cells. How PNECs sense and respond to external stimuli remains poorly understood. We discovered PNECs located within pig a
Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus
Autor:
Yuliang Xie, Tony Jun Huang, David A. Stoltz, Thomas O. Moninger, Lin Lu, Michael J. Welsh, Xiao Xiao Tang
Publikováno v:
Dev Cell
In response to respiratory insults, airway submucosal glands secrete copious mucus strands to increase mucociliary clearance and protect the lung. However, in cystic fibrosis, stimulating submucosal glands has the opposite effect, disrupting mucocili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e0bb8e62180e0b625b81b7ac6d30c1
https://europepmc.org/articles/PMC7484121/
https://europepmc.org/articles/PMC7484121/
Autor:
Erica N. LeClair, David A. Stoltz, Nicholas D. Gansemer, Katherine N. Gibson-Corley, Paul B. McCray, Michael J. Welsh, Mariah R. Leidinger, Sarah E. Ernst, Carrie K. Barker, Matthew D. Strub, Ryan J. Adam, Daniel P. Cook, Philip H. Karp, David K. Meyerholz
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Loss of cystic fibrosis transmembrane conductance regulator (CFTR) function causes cystic fibrosis (CF), predisposing the lungs to chronic infection and inflammation. In young infants with CF, structural airway defects are increasingly recognized bef
Publikováno v:
The FASEB Journal. 33
Autor:
Kelly Q. Schoenfelt, Katherine B. Hisert, B. Grogan, J. Launspach, Gordon Cooke, Charles G. Gallagher, Seamas C. Donnelly, Lev Becker, Pradeep K. Singh, Michael J. Welsh, Edward F. McKone
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:594-597
Autor:
Chunyue Zhao, Lianggong Ding, Yuhong Li, Dengshun Miao, Kai Liu, Ye Lei, Michael J. Welsh, Hermann Steller, Hui Yang, Shuting Han, Lei Liu, Wei Tao
Publikováno v:
Proceedings of the National Academy of Sciences. 111:13960-13965
Neuronal necrosis induced by calcium overload causes devastating brain dysfunction in diseases such as stroke and brain trauma. It has been considered a stochastic event lacking genetic regulation, and pharmacological means to suppress neuronal necro
Autor:
Viral Shah, Ashley L. Cooney, Mallory R. Stroik, Mahmoud H. Abou Alaiwa, Patrick L. Sinn, Michael J. Welsh, David K. Meyerholz, Linda S. Powers, David A. Stoltz, Nicholas D. Gansemer, Drake C. Bouzek, Paul B. McCray
Publikováno v:
JCI Insight. 1
Cystic Fibrosis (CF) is an autosomal recessive disease caused by mutations in CF transmembrane conductance regulator (CFTR), resulting in defective anion transport. Regardless of the disease-causing mutation, gene therapy is a strategy to restore ani
Autor:
Michael J. Welsh, Christine L. Wohlford-Lenane, Scott D. Rose, Peng Jiang, Ashley M. Jacobi, Mark A. Behlke, Kim A. Lennox, Philip H. Karp, Yi Xing, Samantha R. Osterhaus, Shyam Ramachandran, Kal Praekh, Paul B. McCray
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:544-551
MicroRNAs (miRNAs) are increasingly recognized as important posttranscriptional regulators of gene expression, and changes in their actions can contribute to disease states. Little is understood regarding miRNA functions in the airway epithelium unde