Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Michael J. Kruhlak"'
Publikováno v:
Biochemical and Biophysical Research Communications. 663:171-178
Autor:
Gareth N. Corry, Juan Ausió, Darin McDonald, Hilmar Strickfaden, John Th'ng, Michèle Rouleau, Guy G. Poirier, Toyotaka Ishibashi, Jean-François Haince, Michael J. Kruhlak, D. Alan Underhill, Michael J. Hendzel
Publikováno v:
Journal of Biological Chemistry. 291:1789-1802
Chromatin undergoes a rapid ATP-dependent, ATM and H2AX-independent decondensation when DNA damage is introduced by laser microirradiation. Although the detailed mechanism of this decondensation remains to be determined, the kinetics of decondensatio
Autor:
Jeremy M. Stark, Andrea K. Byrum, Elsa Callen, Nancy Wong, Andre Stanlie, Yaakov Maman, Nima Mosammaparast, Raphael Souza Pavani, Michael J. Kruhlak, Amanda Day, Wei Wu, André Nussenzweig, Lavinia C. Dumitrache, Peter J. McKinnon, Dali Zong, Andres Canela, Maria A. Blasco, Carlos Mendez-Dorantes, Paula Martinez, Momoko Ishikawa
Publikováno v:
Mol Cell
Summary 53BP1 activity drives genome instability and lethality in BRCA1-deficient mice by inhibiting homologous recombination (HR). The anti-recombinogenic functions of 53BP1 require phosphorylation-dependent interactions with PTIP and RIF1/shieldin
Autor:
Golnaz Vahedi, Maxwell R. Mumbach, Shawn C. Little, Naomi Goldman, Yeqiao Zhou, Jon C. Aster, Stephen C. Blacklow, Zachary Zapataro, Warren S. Pear, Jelena Petrovic, Kelly S. Rome, Gregory W. Schwartz, Yogev Sela, Maria Fasolino, Michael J. Kruhlak, Eric F. Joyce, Son C. Nguyen, Junwei Shi, Robert B. Faryabi
Publikováno v:
Molecular cell. 73(6)
Chromatin loops enable transcription factor-bound distal enhancers to interact with their target promoters to regulate transcriptional programs. Although developmental transcription factors, such as active forms of Notch, can directly stimulate trans
Autor:
Carolyn K. Goldman, Richard N. Bamford, Michael N. Petrus, Thomas A. Waldmann, Michael J. Kruhlak, Jing Chen, Vinh-Phuc Nguyen
Publikováno v:
Journal of Innate Immunity. 6:377-393
Toll/IL-1R domain-containing adaptor inducing interferon-ß (IFN-ß) factor (TRIF) is a key adaptor for Toll-like receptor (TLR) 3 and TLR4 signaling. Using a novel cDNA isolate encoding a TRIF protein with a 21-residue deletion (Δ160-181) from its
Autor:
Jeremy A. Daniel, Oscar Fernandez-Capetillo, Anthony T. Tubbs, Ji-Eun Lee, Linda M. Starnes, Michael J. Kruhlak, Federica Polato, Frederick W. Alt, Hua Tang Chen, Kai Ge, Elsa Callen, Barry P. Sleckman, Michel C. Nussenzweig, Robert B. Faryabi, Margarida A. Santos, Maria Nieto-Soler, Duane R. Wesemann, André Nussenzweig, Michela Di Virgilio, Nancy Wong
Publikováno v:
Cell. 153:1266-1280
SummaryThe DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologous recombination (HR). During S phase, BRCA1 antagonizes 53BP1 to
Publikováno v:
Journal of Biological Chemistry. 287:40328-40338
IL-15 can either be transpresented by IL-15Rα or be secreted.New N- and C-terminal splice versions of human IL-15Rα determine whether IL-15 is secreted or stays bound to the cell membrane.IL-15Rα isoforms determine the mode of action of IL-15.IL-1
Autor:
Manuela Fahrleitner, Bernhard Nieswandt, Sabine Ring, Sven G. Meuth, Stephan Gnerlich, Alexander Enk, Stefan W. Schneider, Björn F. Krämer, Tanja Schönberger, Michael J. Kruhlak, Meinrad Gawaz, Sarah Gehring, Harald F. Langer, Anke S. Lonsdorf
Publikováno v:
Journal of Biological Chemistry. 287:2168-2178
A mutual relationship exists between metastasizing tumor cells and components of the coagulation cascade. The exact mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understood. Here, we used murine B16 melanoma
Autor:
Michel C. Nussenzweig, André Nussenzweig, Elsa Callen, Ferenc Livak, Barry P. Sleckman, Michael J. Kruhlak, Eric J. Gapud, Hua Tang Chen, Nancy Wong, Grace K. Mahowald, Simone Difilippantonio, Ching-Yu Huang
Publikováno v:
Nature
Variable, diversity and joining (V(D)J) recombination and class-switch recombination use overlapping but distinct non-homologous end joining pathways to repair DNA double-strand-break intermediates. 53BP1 is a DNA-damage-response protein that is rapi
Autor:
Eric Allemand, Koji Yamanegi, Adrian R. Krainer, Michael J. Kruhlak, Vladimir Majerciak, Zhi-Ming Zheng
Publikováno v:
Journal of Virology. 82:2792-2801
Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 facilitates the expression of both intronless viral ORF59 genes and intron-containing viral K8 and K8.1 genes (V. Majerciak, N. Pripuzova, J. P. McCoy, S. J. Gao, and Z. M. Zheng, J. Virol. 81:1062