Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Maria Sasvari-Szekely"'
Autor:
Maria Sasvari-Szekely, Zsolt Ronai, Eniko Kubinyi, Giulia Cimarelli, Zsófia Virányi, Zsófia Bánlaki
Publikováno v:
Molecular Genetics and Genomics. 292:685-697
A growing body of evidence highlights the relationship between epigenetics, especially DNA methylation, and population divergence as well as speciation. However, little is known about how general the phenomenon of epigenetics-wise separation of diffe
Autor:
Zsolt Ronai, Zsuzsanna Molnár, Gergely Keszler, Anna Szekely, Maria Sasvari-Szekely, Eszter Kotyuk
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226228 (2019)
PLoS ONE, Vol 14, Iss 12, p e0226228 (2019)
Background Galanin, an inhibitory neuropeptide and cotransmitter has long been known to co-localize with noradrenaline and serotonin in the central nervous system. Several human studies demonstrated altered galanin expression levels in major depressi
Publikováno v:
ELECTROPHORESIS. 35:379-384
The 25 kDa synaptosomal-associated protein (SNAP-25) is a crucial component of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex and plays an important role in neurotransmission in the central nervous system. SNAP-25 h
Publikováno v:
Journal of Neural Transmission. 119:17-24
Histone deacetylase inhibitors are promising anti-tumor agents partly due to their ability to disrupt the hypoxic signaling pathway in human malignancies. However, little is known about any effects of these drugs on the central nervous system. The ai
Publikováno v:
Journal of Chromatography A. 1079:41-49
The investigation of the genetic background and phenotype structures of complex diseases, such as cardiovascular or psychiatric disorders and tumors, is one of the most scrutinized fields of the post genomic era. Besides the multiplex analysis of gen
Autor:
Gergely Keszler, Tatjana Spasokoukotskaja, Szula Virga, Pal I. Bauer, Maria Sasvari-Szekely, Maria Staub
Publikováno v:
Archives of Biochemistry and Biophysics. 436:69-77
The inborn deficiency of adenosine deaminase is characterised by accumulation of excess amounts of cytotoxic deoxyadenine nucleotides in lymphocytes. Formation of dATP requires phosphorylation of deoxyadenosine by deoxycytidine kinase (dCK), the main
Autor:
Gergely Keszler, Maria Staub, Iannis Talianidis, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely, Zsolt Csapó, Staffan Eriksson
Publikováno v:
Biochemical Pharmacology. 67:947-955
Deoxycytidine kinase (dCK), the principal deoxynucleoside salvage enzyme, plays a seminal role in the bioactivation of a wide array of cytotoxic nucleoside analogues. Recently, activation of dCK has been considered as a protective cellular response t
Autor:
Judit Gervai, Eszter Szantai, Zsolt Ronai, Maria Sasvari-Szekely, Zsofia Nemoda, András Guttman, Anna Szekely, R. Szmola
Publikováno v:
American Journal of Medical Genetics. :74-78
The polymorphic 5′ upstream region of the dopamine D4 receptor (DRD4) gene containing several single nucleotide polymorphisms (SNPs) has recently become a focus of association studies in psychiatric genetics. Most SNP genotyping methods are based o
Autor:
Gergely Keszler, Zsolt Csapó, Maria Staub, Géza Sáfrány, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely, Iannis Talianidis
Publikováno v:
Biochemical Pharmacology. 65:2031-2039
Deoxycytidine kinase (dCK) is a key enzyme in the intracellular metabolism of deoxynucleosides and their analogues, phosphorylating a wide range of drugs used in the chemotherapy of leukaemia and solid tumours. Previously, we found that activity of d
Publikováno v:
International journal of immunogenetics. 41(6)
Summary Several lines of evidence suggest that certain subtypes of obsessive-compulsive and tic disorders might be paediatric manifestations of post-streptococcal autoimmunity caused by cross-reactive autoantibodies. As tumor necrosis factor (TNF) is