Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Karel Souček"'
Autor:
Daniela Kurfürstová, Milan Král, Alena Mickova, Jan Bouchal, Barbora Pokryvkova, Mariam Gachechiladze, Ondrej Vacek, Karel Souček, Martin Mistrik, Gvantsa Kharaishvili
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2844, p 2844 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences
Volume 22
Issue 6
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in Western countries, and there is still an urgent need for a better understanding of PCa progression to inspire new treatment strategies. Skp2 is a substrate-recruitin
Publikováno v:
Non-Coding RNA
Non-Coding RNA, Vol 7, Iss 75, p 75 (2021)
Non-Coding RNA, Vol 7, Iss 75, p 75 (2021)
Neuroendocrine prostate cancer (NEPC) represents a variant of prostate cancer that occurs in response to treatment resistance or, to a much lesser extent, de novo. Unravelling the molecular mechanisms behind transdifferentiation of cancer cells to ne
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that ep
Autor:
Peter Kollar, Tatiana Syrovets, Tereza Kauerová, Radek Fedr, Tomáš Goněc, Ann-Kathrin Gaiser, Karel Souček, Josef Jampilek, Susanne Hafner
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3416, p 3416 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 10
International Journal of Molecular Sciences
Volume 21
Issue 10
Ring-substituted 1-hydroxynaphthalene-2-carboxanilides were previously investigated for their antimycobacterial properties. In our study, we have shown their antiproliferative and cell death-inducing effects in cancer cell lines. Cell proliferation a
Publikováno v:
Differentiation. 78:213-222
Survival and capability of cancer cells to form metastases fundamentally depend on interactions with their microenvironment. Secondary tumors originating from prostate carcinomas affect remodeling of bone tissue and can induce both osteolytic and ost
Autor:
Jana Slováčková, Jan Šmarda, Eva Ondroušková, Jiřina Procházková, Vendula Pelková, Karel Souček, Petr Beneš
Publikováno v:
bchm. 390:49-58
The Bcl-2 protein is one of the key components of biochemical pathways controlling programmed cell death. The function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significant
Autor:
Petr Dvořák, Jiří Pacherník, Viktor Horváth, Zuzana Holubcová, Jan Vondráček, Aleš Hampl, Vítězslav Bryja, Karel Souček, Lukas Cajanek
Publikováno v:
Cell Proliferation
Objectives: This article is to study the role of G1/S regulators in differentiation of pluripotent embryonic cells. Materials and methods: We established a P19 embryonal carcinoma cell-based experimental system, which profits from two similar differe
Autor:
Tomáš Bárta, Karel Šmejkal, Veronika Závalová, Jan Hošek, Pavlína Trnová, Peter Kollar, Aleš Hampl, Karel Souček, Stanislava Keltosova, Radek Fedr
Publikováno v:
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015)
Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015)
Aims. In this work we studied cytodifferentiation effects of newly characterized prenyl flavonoid 4′-O-methylkuwanon E (4ME) isolated from white mulberry (Morus albaL.).Main Methods. Cell growth and viability were measured by dye exclusion assay; c
Autor:
Ales Kroutil, Petr Sova, Jirina Hofmanova, Alois Kozubík, Peter Fedoročko, Lenka Svihálková-Sindlerová, Olga Blanárová, Karel Souček, Viktor Horváth
Publikováno v:
Gynecologic Oncology. 102:32-40
Objectives. The resistance of tumor cells to cisplatin remains a major cause of treatment failure in cancer patients. In this study, the ability of Pt(IV) complex with adamantylamine-LA-12 and its reduced counterpart with lower oxidation state Pt(II)
Autor:
Viktor Horváth, Ales Kroutil, Adolf Mistr, Alois Kozubík, Petr Sova, František Žák, Jiřina Hofmanová, Jaroslav Turánek, Lenka Svihálková-Sindlerová, Karel Souček
Publikováno v:
Biochemical Pharmacology. 69:373-383
[(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)], coded as LA-12, is an octahedral platinum(IV) complex containing a bulky hydrophobic ligand - adamantylamine. The use of bulky hydrophobic amines as non-leaving ligands, may increa