Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Kah-Leong Lim"'
Autor:
Willcyn Tang, John Thundyil, Grace Gui Yin Lim, Teddy J W Tng, Sean Qing Zhang Yeow, Aditya Nair, Chou Chai, Tso-Pang Yao, Kah-Leong Lim
Publikováno v:
Human Molecular Genetics. 32:1466-1482
Abnormal lipid homeostasis has been observed in the brain of Parkinson's disease (PD) patients and experimental models, although the mechanism underlying this phenomenon is unclear. Notably, previous studies have reported that the PD-linked protein P
Autor:
Yue Wu, Zhongting Zhao, Naidi Yang, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu, Changmin Yu, Chengwu Zhang
Publikováno v:
Antioxidants; Volume 12; Issue 1; Pages: 153
Parkinson’s disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains inc
Parkinson's Disease (PD) is a prevalent neurodegenerative disorder that is characterized pathologically by the loss of A9-specific dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472125c5d2bed2f87fe9aa175730e8ad
https://hdl.handle.net/10356/165606
https://hdl.handle.net/10356/165606
Autor:
Zhi Dong Zhou, Wuan Ting Saw, Patrick Ghim Hoe Ho, Zhi Wei Zhang, Li Zeng, Ya Yin Chang, Alfred Xu Yang Sun, Dong Rui Ma, Hong Yan Wang, Lei Zhou, Kah Leong Lim, Eng-King Tan
Publikováno v:
Cellular and Molecular Life Sciences. 79
Background Parkinson’s disease (PD) is characterized by selective and progressive dopamine (DA) neuron loss in the substantia nigra and other brain regions, with the presence of Lewy body formation. Most PD cases are sporadic, whereas monogenic for
Autor:
Chao‐Chieh Lin, Jin Yan, Meghan D Kapur, Kristi L Norris, Cheng‐Wei Hsieh, De Huang, Nicolas Vitale, Kah‐Leong Lim, Ziqiang Guan, Xiao‐Fan Wang, Jen‐Tsan Chi, Wei‐Yuan Yang, Tso‐Pang Yao
Publikováno v:
EMBO reports. 23
Autophagy has emerged as the prime machinery for implementing organelle quality control. In the context of mitophagy, the ubiquitin E3 ligase Parkin tags impaired mitochondria with ubiquitin to activate autophagic degradation. Although ubiquitination
Autor:
Venetia Kok Jing Tong, Sylvester Wong Shu Ming, Kah-Leong Lim, Ziyin Wang, Rafhanah Banu Bte Abdul Razar, Saravanan Gunaseelan, Sumitra Srimasorn, Wei-Yi Ong, John Jia En Chua
Publikováno v:
Human Molecular Genetics. 30:5-20
FEZ1-mediated axonal transport plays important roles in central nervous system development but its involvement in the peripheral nervous system is not well-characterized. FEZ1 is deleted in Jacobsen syndrome (JS), an 11q terminal deletion development
Publikováno v:
Microbiology Resource Announcements
In nature, the fruit fly frequently encounters various pathogens that cause a decrease in host fitness. Here, we present the genome sequence of Serratia marcescens strain FY that was isolated from the intestines of a Drosophila sp. specimen. The comp
Autor:
Chun-Hyung Kim, Hye Min Park, Xue-Wei Liu, Choong Hwan Lee, Bin Song, Sungwhan F. Oh, CongBao Kang, Sreekanth Rajan, Geraldine W.Y. Goh, Gregory A. Petsko, Aida Serra, Jeha Jeon, Hong Ye, Yongwoo Jang, Serap Beldar, Kah-Leong Lim, Woori Kim, Jun Yeob Yoo, Melissa Feitosa, Ho Sup Yoon, Dabin Hwang, Hui Ting Toh, Yeahan Kim, Kwang-Soo Kim, Julien Lescar
Publikováno v:
Nat Chem Biol
The orphan nuclear receptor Nurr1 is critical for the development, maintenance and protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 (PGE1) and its dehydrated metabolite, PGA1, directly interact with the ligand-bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd588e0ced5ac7d9716ad1af8cedaca4
https://hdl.handle.net/10356/155280
https://hdl.handle.net/10356/155280
Autor:
Kah-Leong Lim, Bin Xiao, Zhi Dong Zhou, Xiao Deng, Wei Zhou, Eng-King Tan, Wuan-Ting Saw, Grace Lim
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:1308-1317
Parkin/PINK1-mediated mitophagy is implicated in the pathogenesis of Parkinson's disease (PD). Prior to elimination of damaged mitochondria, Parkin translocates to mitochondria and induces mitochondrial clustering. While the mechanism of PINK1-depend
Autor:
Mor Savyon, Fatimah Abd Elghani, Ruth Rott, Kah-Leong Lim, Tsipora Cohen, Rina Bandopadhyay, Ninghan Wang, Raymonde Szargel, Simone Engelender, Vered Shani, Lihi Shaulov, Christopher A. Ross, Hazem Safory, Hui Zhang, Inna Radzishevsky, Haya Hamza
Publikováno v:
Hum Mol Genet
Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease, but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolo