Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jukka Sirén"'
Publikováno v:
Molecular Biology and Evolution
Reconstruction of the past is an important task of evolutionary biology. It takes place at different points in a hierarchy of molecular variation, including genes, individuals, populations, and species. Statistical inference about population historie
Publikováno v:
Journal of Leukocyte Biology. 82:1185-1192
IL-27 is a novel member of the IL-12 cytokine family. IL-27 has pro- and anti-inflammatory properties, and it controls the responses of adaptive immunity. It promotes the differentiation of naïve Th cells and suppresses the effector functions of Th1
Autor:
Timo Sareneva, Don Foster, Anne Lehtonen, Sampsa Matikainen, Ilkka Julkunen, Jukka Sirén, Mari Strengell
Publikováno v:
The Journal of Immunology. 170:5464-5469
NK and T cell-derived IFN-γ is a key cytokine that stimulates innate immune responses and directs adaptive T cell response toward Th1 type. IL-15, IL-18, and IL-21 have significant roles as activators of NK and T cell functions. We have previously s
Publikováno v:
Molecular Biology and Evolution
Phylogeographical analyses have become commonplace for a myriad of organisms with the advent of cheap DNA sequencing technologies. Bayesian model-based clustering is a powerful tool for detecting important patterns in such data and can be used to dec
Publikováno v:
Molecular Biology and Evolution
Population genetics encompasses a strong theoretical and applied research tradition on the multiple demographic processes that shape genetic variation present within a species. When several distinct populations exist in the current generation, it is
Publikováno v:
BMC Bioinformatics, Vol 9, Iss 1, p 539 (2008)
BMC Bioinformatics
BMC Bioinformatics
Background During the most recent decade many Bayesian statistical models and software for answering questions related to the genetic structure underlying population samples have appeared in the scientific literature. Most of these methods utilize mo
Autor:
John Hiscott, Ilkka Julkunen, Jaana Pirhonen, Jukka Sirén, Seppo Meri, Jorma Tissari, Martina Severa, Ville Veckman, Rongtuan Lin, Gilles Uzé, Qiang Sun, Sampsa Matikainen
Publikováno v:
Journal of virology. 80(7)
Epithelial cells of the lung are the primary targets for respiratory viruses. Virus-carried single-stranded RNA (ssRNA) can activate Toll-like receptors (TLRs) 7 and 8, whereas dsRNA is bound by TLR3 and a cytoplasmic RNA helicase, retinoic acid-indu
Autor:
Diana L. Noah, Sampsa Matikainen, Ilkka Julkunen, John Hiscott, Taija E. Pietilä, Devanand Sarkar, Rongtuan Lin, Tadaatsu Imaizumi, Jukka Sirén, Robert M. Krug, Paul B. Fisher
Publikováno v:
Microbes and infection. 8(8)
Activation of host cell antiviral responses is mediated by pattern recognition receptors. Cytoplasmic RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (mda-5) have been identified to function as rec
Autor:
Ville Veckman, Pamela Österlund, Jukka Sirén, Ilkka Julkunen, Kevin M. Klucher, Sampsa Matikainen, John Hiscott
Dendritic cells (DCs) respond to microbial infections by undergoing phenotypic maturation and by producing multiple cytokines. In the present study, we analyzed the ability of influenza A and Sendai viruses to induce DC maturation and activate tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d53b81c3fa54cfdf7b0326d848b028
https://europepmc.org/articles/PMC1181545/
https://europepmc.org/articles/PMC1181545/
Publikováno v:
University of Helsinki
TLRs play a critical role in early innate immune response to virus infection. TLR3 together with TLR7 and TLR8 constitute a powerful system to detect genetic material of RNA viruses. TLR3 has been shown to bind viral dsRNA whereas TLR7 and TLR8 are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bcf678ea48843bfc73e75d88c71564
https://tuhat.helsinki.fi/portal/en/publications/ifnalpha-enhances-tlr3mediated-antiviral-cytokine-expression-in-human-endothelial-and-epithelial-cells-by-upregulating-tlr3-expression(2e829661-552a-4038-8eee-229d12a1e58a).html
https://tuhat.helsinki.fi/portal/en/publications/ifnalpha-enhances-tlr3mediated-antiviral-cytokine-expression-in-human-endothelial-and-epithelial-cells-by-upregulating-tlr3-expression(2e829661-552a-4038-8eee-229d12a1e58a).html