Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joris Beld"'
Publikováno v:
Journal of Bacteriology.
The rise of antibiotic-resistant pathogens poses a challenge to public health. The gut microbiome presents a promising source of new antimicrobials and treatments.
Autor:
Kimberly C. Grasty, Claudia Guzik, Elizabeth J. D’Lauro, Shae B. Padrick, Joris Beld, Patrick J. Loll
Publikováno v:
Journal of Biological Chemistry. 299:103001
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Molecular Microbiology. 113:89-102
Cobamides are a group of compounds including vitamin B12 that can vary at the lower base position of the nucleotide loop. They are synthesized de novo by only a subset of prokaryotes, but some organisms encode partial biosynthesis pathways for conver
Autor:
Joris Beld, Amy T. Ma
Publikováno v:
J Bacteriol
Vitamin B(12) belongs to a family of structurally diverse cofactors with over a dozen natural analogs, collectively referred to as cobamides. Most bacteria encode cobamide-dependent enzymes, many of which can only utilize a subset of cobamide analogs
Autor:
Michael D. Burkart, Joseph J. Hale, Shiou-Chuan Tsai, D. John Lee, David R. Jackson, Ray Luo, Jesus F. Barajas, Joris Beld, Andrew J. Schaub, Jacob C. Milligan
Publikováno v:
Nature chemical biology, vol 15, iss 7
Nat Chem Biol
Nat Chem Biol
Fatty acid synthases are dynamic ensembles of enzymes that can biosynthesize long hydrocarbon chains efficiently. Here we visualize the interaction between the Escherichia coli acyl carrier protein (AcpP) and β-ketoacyl-ACP-synthase I (FabB) using X
Autor:
Anthony A. Mrse, Michael D. Burkart, Rufina Hernandez-Martinez, Joris Beld, Carla C. Uranga, Iván Córdova-Guerrero
Publikováno v:
Biochemical and Biophysical Research Communications. 472:339-345
The Botryosphaeriaceae are a family of trunk disease fungi that cause dieback and death of various plant hosts. This work sought to characterize fatty acid derivatives in a highly virulent member of this family, Lasiodiplodia theobromae. Nuclear magn
Publikováno v:
Molecular BioSystems. 12:1299-1312
In both eukaryotes and prokaryotes, fatty acid synthases are responsible for the biosynthesis of fatty acids in an iterative process, extending the fatty acid by two carbon units every cycle. Thus, odd numbered fatty acids are rarely found in nature.
Autor:
Eva C. Sonnenschein, Christopher R. Vickery, Joris Beld, Ian P. McCulloch, Michael D. Burkart, Joseph P. Noel
Publikováno v:
Vickery, C R, McCulloch, I P, Sonnenschein, E, Beld, J, Noel, J P & Burkart, M D 2020, ' Dissecting modular synthases through inhibition: A complementary chemical and genetic approach ', Bioorganic & Medicinal Chemistry Letters, vol. 30, no. 2, 126820 . https://doi.org/10.1016/j.bmcl.2019.126820
Modular synthases, such as fatty acid, polyketide, and non-ribosomal peptide synthases (NRPSs), are sophisticated machineries essential in both primary and secondary metabolism. Various techniques have been developed to understand their genetic backg
Autor:
Marco A. Rivas, Louise K. Charkoudian, Valentine C. Courouble, Ashley C. Sisto, Bashkim Kokona, Joris Beld
Publikováno v:
The FASEB Journal. 32
Engineering biosynthetic pathways in microorganisms is a compelling route to gain access to novel molecules with drug-like properties. Polyketide synthases (PKSs) utilize acyl carrier proteins (ACP...