Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jorge Cruz-Reyes, Andrew Hillhouse, Daniel Camilo Osorio Hurtado, Alasdair Ivens, Xiuren Zhang, Pawan K. Doharey, Joshua Meehan, Zachary T Goodall, Achim Schnaufer, Vikas Kumar, James J. Cai
Publikováno v:
Kumar, V, Ivens, A, Goodall, Z, Meehan, J, Doharey, P K, Hillhouse, A, Hurtado, D O, Cai, J J, Zhang, X, Schnaufer, A & Cruz-Reyes, J 2020, ' Site-specific and mRNA-specific control of accurate mRNA editing by a helicase complex in trypanosomes ', RNA, vol. 26, no. 10, rna.076513.120 . https://doi.org/10.1261/rna.076513.120
RNA
RNA
Trypanosome U-insertion/deletion RNA editing in mitochondrial mRNAs involves guide RNAs (gRNAs) and the auxiliary RNA editing substrate binding complex (RESC) and RNA editing helicase 2 complex (REH2C). RESC and REH2C stably copurify with editing mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7544f1407045fc8df53ea00d87dc63e7
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
Publikováno v:
WIREs RNA. 9
Publikováno v:
WIREs RNA. 9
RNA editing causes massive remodeling of the mitochondrial mRNA transcriptome in trypanosomes and related kinetoplastid protozoa. This type of editing involves the specific insertion or deletion of uridylates (U) directed by small noncoding guide RNA
Autor:
Jason Carnes, Suzanne M. McDermott, Kenneth Stuart, Ira J. Blader, Juan Alfonzo, Jorge Cruz-Reyes
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
mSphere, Vol 3, Iss 1, p e00585-17 (2018)
mSphere, Vol 3, Iss 1, p e00585-17 (2018)
Editosomes are the multiprotein complexes that catalyze the insertion and deletion of uridines to create translatable mRNAs in the mitochondria of kinetoplastids. Recognition and cleavage of a broad diversity of RNA substrates in vivo require three f
Autor:
Richard P. Metz, Bhaskara R. Madina, Blaine H. M. Mooers, Jorge Cruz-Reyes, Ralf Bundschuh, Vikas Kumar
Publikováno v:
RNA. 20:1142-1152
Mitochondrial mRNAs in kinetoplastids require extensive U-insertion/deletion editing that progresses 3′-to-5′ in small blocks, each directed by a guide RNA (gRNA), and exhibits substrate and developmental stage-specificity by unsolved mechanisms.
Autor:
James A. Wohlschlegel, Gokulan Kuppan, Sing-Hoi Sze, Yu-He Liang, Xinhua Ji, Bhaskara R. Madina, Laurie K. Read, Kurtis M. Downey, Ajay A. Vashisht, James C. Sacchettini, Jorge Cruz-Reyes
Publikováno v:
RNA. 17:1821-1830
The mitochondrial genome of kinetoplastids, including species of Trypanosoma and Leishmania, is an unprecedented DNA structure of catenated maxicircles and minicircles. Maxicircles represent the typical mitochondrial genome encoding components of the
Autor:
Bhaskara R. Madina, Michael Kinter, Kevin Ro, Alfredo J. Hernandez, Belinda Willard, James A. Wohlschlegel, Jorge Cruz-Reyes
Publikováno v:
Journal of Biological Chemistry. 285:1220-1228
Regulation of gene expression in kinetoplastid mitochondria is largely post-transcriptional and involves the orchestration of polycistronic RNA processing, 3′-terminal maturation, RNA editing, turnover, and translation; however, these processes rem
Publikováno v:
RNA. 12:1292-1303
RBP16 is an abundant RNA binding protein from Trypanosoma brucei mitochondria that affects both RNA editing and stability. We report here experiments aimed at elucidating the mechanism of RBP16 function in RNA editing. In in vitro RNA editing assays,
Autor:
Alevtina G. Zhelonkina, Julie A. Law, Jorge Cruz-Reyes, Barbara Sollner-Webb, Catherine E. Huang, Vadim S. Alatortsev, Sean F. O'Hearn
Publikováno v:
RNA. 12:476-487
Trypanosome RNA editing is massive post-transcriptional U-insertion and U-deletion, which generates mature mRNA coding regions through cycles of endonuclease, terminal U transferase (TUTase) or 3′-U-exo, and ligase action. Both types of editing are
Publikováno v:
Molecular and Cellular Biology. 22:4652-4660
Trypanosome RNA editing is a unique U insertion and U deletion process that involves cycles of pre-mRNA cleavage, terminal U addition or U removal, and religation. This editing can occur at massive levels and is directed by base pairing of trans-acti