Zobrazeno 1 - 10
of 90
pro vyhledávání: '"James A. Wohlschlegel"'
Autor:
Lisa Ta, Brandon L. Tsai, Weixian Deng, Jihui Sha, Grigor Varuzhanyan, Wendy Tran, James A. Wohlschlegel, Janai R. Carr-Ascher, Owen N. Witte
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108480- (2023)
Summary: Mutated Ras and Raf kinases are well-known to promote cancer metastasis via flux through the Ras/Raf/MEK/ERK (mitogen-activated protein kinase [MAPK]) pathway. A role for non-mutated Raf in metastasis is also emerging, but the key mechanisms
Externí odkaz:
https://doaj.org/article/50c08eec40e64d8eaf3c2bad01473b66
Autor:
Yalda Afshar, Feyiang Ma, Austin Quach, Anhyo Jeong, Hannah L Sunshine, Vanessa Freitas, Yasaman Jami-Alahmadi, Raphael Helaers, Xinmin Li, Matteo Pellegrini, James A Wohlschlegel, Casey E Romanoski, Miikka Vikkula, M Luisa Iruela-Arispe
Publikováno v:
eLife, Vol. 12, p. 1-29 (2023)
Environmental cues, such as physical forces and heterotypic cell interactions play a critical role in cell function, yet their collective contributions to transcriptional changes are unclear. Focusing on human endothelial cells, we performed broad in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c9361808c0d1789ab1e3ed4b4ff38c
https://escholarship.org/uc/item/0s3616zd
https://escholarship.org/uc/item/0s3616zd
Autor:
Emily Yang, Serina Huang, Yasaman Jami-Alahmadi, Gerald M. McInerney, James A. Wohlschlegel, Melody M. H. Li
Publikováno v:
PLoS pathogens, vol 18, iss 9
The tripartite motif (TRIM) family of E3 ubiquitin ligases is well known for its roles in antiviral restriction and innate immunity regulation, in addition to many other cellular pathways. In particular, TRIM25-mediated ubiquitination affects both ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00fc4b13ff9bfd105cf0c7d68512ccf
https://escholarship.org/uc/item/40f6t9vn
https://escholarship.org/uc/item/40f6t9vn
Autor:
Paul Kang, Bernice Fellows, Ajay A. Vashisht, William Martelly, James A. Wohlschlegel, Shalini Sharma
Publikováno v:
RNA Biol
During spliceosome assembly, interactions that bring the 5′ and 3′ ends of an intron in proximity are critical for the production of mature mRNA. Here, we report synergistic roles for the stem-loops 3 (SL3) and 4 (SL4) of the human U1 small nucle
Autor:
Nehuén Salas, Veronica M. Coceres, Tuanne dos Santos Melo, Antonio Pereira-Neves, Vanina G. Maguire, Tania M. Rodriguez, Bruna Sabatke, Marcel I. Ramirez, Jihui Sha, James A. Wohlschlegel, Natalia de Miguel
Publikováno v:
Cellular and Molecular Life Sciences. 79
Autor:
Michele Bianchi, Ubaldina Galli, Marta Calabrò, Giuseppe Orsomando, Sara Boumya, Simone Torretta, Francesca Mazzola, Federica Gaudino, Ambra A. Grolla, Erika Del Grosso, Alessandro Gori, Xiaorui Fan, Francesca Rocchio, Giorgia Colombo, Silvia Garavaglia, Martina Guarneri, Armando A. Genazzani, Eleonora Aronica, Daniele Di Marino, Cristina Travelli, Carlo Angeletti, Silvia Deaglio, Riccardo Miggiano, Menico Rizzi, James A. Wohlschlegel
Publikováno v:
'Journal of Biological Chemistry ', vol: 295, pages: 3635-3651 (2020)
J Biol Chem
Journal of biological chemistry (Online) 295 (2020): 3635–3651. doi:10.1074/jbc.RA119.010571
info:cnr-pdr/source/autori:Grolla A.A.; Miggiano R.; Marino D.D.; Bianchi M.; Gori A.; Orsomando G.; Gaudino F.; Galli U.; Grosso E.D.; Mazzola F.; Angeletti C.; Guarneri M.; Torretta S.; Calabro M.; Boumya S.; Fan X.; Colombo G.; Travelli C.; Rocchio F.; Aronica E.; Wohlschlegel J.A.; Deaglio S.; Rizzi M.; Genazzani A.A.; Garavaglia S./titolo:A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN%2FNAD+ salvage pathway in the nucleus/doi:10.1074%2Fjbc.RA119.010571/rivista:Journal of biological chemistry (Online)/anno:2020/pagina_da:3635/pagina_a:3651/intervallo_pagine:3635–3651/volume:295
Journal of biological chemistry, 295(11), 3635-3651. American Society for Biochemistry and Molecular Biology Inc.
J Biol Chem
Journal of biological chemistry (Online) 295 (2020): 3635–3651. doi:10.1074/jbc.RA119.010571
info:cnr-pdr/source/autori:Grolla A.A.; Miggiano R.; Marino D.D.; Bianchi M.; Gori A.; Orsomando G.; Gaudino F.; Galli U.; Grosso E.D.; Mazzola F.; Angeletti C.; Guarneri M.; Torretta S.; Calabro M.; Boumya S.; Fan X.; Colombo G.; Travelli C.; Rocchio F.; Aronica E.; Wohlschlegel J.A.; Deaglio S.; Rizzi M.; Genazzani A.A.; Garavaglia S./titolo:A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN%2FNAD+ salvage pathway in the nucleus/doi:10.1074%2Fjbc.RA119.010571/rivista:Journal of biological chemistry (Online)/anno:2020/pagina_da:3635/pagina_a:3651/intervallo_pagine:3635–3651/volume:295
Journal of biological chemistry, 295(11), 3635-3651. American Society for Biochemistry and Molecular Biology Inc.
All cells require sustained intracellular energy flux, which is driven by redox chemistry at the subcellular level. NAD(+), its phosphorylated variant NAD(P)(+), and its reduced forms NAD(P)/NAD(P)H are all redox cofactors with key roles in energy me
Autor:
Anna C. Calkin, James A. Wohlschlegel, Huan Wang, Thurl E. Harris, Ajay A. Vashisht, Tracey W Chan, Brian G. Drew, Xinshu Xiao, Karen Reue
Publikováno v:
JCI Insight
JCI insight, vol 6, iss 17
JCI insight, vol 6, iss 17
Lipin 1 regulates cellular lipid homeostasis through roles in glycerolipid synthesis (through phosphatidic acid phosphatase activity) and transcriptional coactivation. Lipin 1-deficient individuals exhibit episodic disease symptoms that are triggered
Autor:
Katie M. Ulrich, Nevan J. Krogan, James A. Wohlschlegel, Billy W. Newton, David P. Toczyski, Ajay A. Vashisht, Jessica P. Lao, Jeffrey R. Johnson
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 12, Pp 3931-3944 (2018)
G3: Genes|Genomes|Genetics
G3 (Bethesda, Md.), vol 8, iss 12
G3: Genes|Genomes|Genetics
G3 (Bethesda, Md.), vol 8, iss 12
The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling casca
Publikováno v:
Molecular & Cellular Proteomics : MCP
Deep proteome coverage in bottom-up proteomics requires peptide-level fractionation to simplify the complex peptide mixture before analysis by tandem mass spectrometry. By decreasing the number of coeluting precursor peptide ions, fractionation effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8beb0e653acd150619daac3b29b75858
https://escholarship.org/uc/item/1799r54v
https://escholarship.org/uc/item/1799r54v
Autor:
Ahmet C. Berkyurek, Eric A. Miska, Mathieu N. Flamand, Mihail Sarov, Stephanie Merrett, Ajay A. Vashisht, Alexandra Lewis, James A. Wohlschlegel, Ahilya N. Sawh, Thomas F. Duchaine, Andre Greiner
Publikováno v:
Mol Cell
Summary Nuclear RNA interference (RNAi) pathways work together with histone modifications to regulate gene expression and enact an adaptive response to transposable RNA elements. In the germline, nuclear RNAi can lead to trans-generational epigenetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1bfa604efda46eab4db42a0209a34b
https://www.repository.cam.ac.uk/handle/1810/318860
https://www.repository.cam.ac.uk/handle/1810/318860