Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Hiroyuki Watanabe"'
Publikováno v:
Nuclear Medicine and Biology. :93-97
Introduction The deposition of islet amyloid composed of amylin aggregates is related to β-cell mass dysfunction in type 2 diabetes mellitus (T2DM), and it may be involved in the development and progression of T2DM. In this study, we newly designed,
Autor:
Haruka Tatsumi, Hideo Saji, Shimpei Iikuni, Yoichi Shimizu, Sho Kaide, Kaori Togashi, Yuji Nakamoto, Masafumi Ihara, Masahiro Ono, Hiroyuki Watanabe
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:3587-3594
Hyperphosphorylated tau proteins are one of the neuropathological hallmarks in the Alzheimer’s disease (AD) brain. The in vivo imaging of tau aggregates with nuclear medical imaging probes is helpful for the further comprehension of and medical int
Publikováno v:
Molecular pharmaceutics. 18(3)
The expression of carbonic anhydrase-IX (CA-IX) in tumors can lead to a poor prognosis; thus, CA-IX has attracted much attention as a target molecule for cancer diagnosis and treatment. An 111In-labeled imidazothiadiazole sulfonamide (IS) derivative,
Autor:
Yongjun Dang, Helge Frieling, Jennifer R. Geske, Weida Meng, Tomas J. Ekström, Joëlle Rüegg, Gunter Schumann, Olga Kononenko, Louise K. Sjöholm, Wenqing Qiu, Stefan Bleich, Daniil Sarkisyan, Nicole Tay, Radwa Almamoun, Alex Ing, Dandan Zhang, Victor M. Karpyak, Georgy Bakalkin, Donghong Cui, Joanna M. Biernacka, Hiroyuki Watanabe, Yun Liu, R. Dayne Mayfield
Publikováno v:
Molecular Psychiatry
Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e0410ba0142f76e963e7bf71362fc8
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-466959
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-466959
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 53:128417
Human serum albumin (HSA), which is distributed throughout the blood, is used as a carrier for transporting drugs to tumors based on the enhanced permeability and retention (EPR) effect. To develop an agent for the in vivo radiolabeling of endogenous
Autor:
Hiroyuki Watanabe, Masahiro Ono, Sho Kaide, Masashi Yoshimura, Ayane Kitada, Masafumi Ihara, Hideo Saji, Yoichi Shimizu
Publikováno v:
ACS Medicinal Chemistry Letters. 9:478-483
[Image: see text] It is generally accepted that neurofibrillary tangles consisting of tau proteins are involved in the pathogenesis of Alzheimer’s disease (AD). For selective detection of tau pathology, we synthesized and evaluated radioiodinated b
Autor:
Junya Shirai, Yoshiyuki Fukase, Tetsuji Kawamoto, Mitsunori Kono, Tsuneo Oda, Mikio Shirasaki, Yasushi Fujitani, Hiroyuki Watanabe, Hideyuki Nakagawa, Keiko Uga, Michiko Tawada, Naohiro Taya, Akira Shibata, Takashi Imada, Yoshihide Tomata, Masashi Yamasaki, Tomoya Yukawa, Shoji Fukumoto, Hidekazu Tokuhara, Satoshi Yamamoto, Naoki Ishii, Atsuko Ochida, Yoshihiro Banno
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:470-482
A series of tetrahydroisoquinoline derivatives were designed, synthesized, and evaluated for their potential as novel orally efficacious retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of Th17-driven
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6398-6403
α-Synuclein (α-syn) aggregates are commonly found in the brains of patients with Parkinson's disease (PD), dementia with Lewy bodies (DLB), and some other diseases. Therefore, in vivo imaging of α-syn aggregates would aid in drug development, earl
Autor:
Hirokazu Matsuda, Yusuke Yagi, Keita Hamamatsu, Hiroyuki Watanabe, Hideo Saji, Hiroyuki Fujimoto, Kaori Kanbe, Masahiro Ono, Hiroyuki Kimura, Nobuya Inagaki, Kenji Arimitsu, Naotaka Fujita
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5772-5778
A non-invasive method of pancreatic β-cell mass measurement is needed to enhance our understanding of the pathogenesis of diabetes, facilitate the early diagnosis of this disease, and promote the development of novel therapeutics. Here, we described
Publikováno v:
Journal of Agricultural and Food Chemistry. 65:8386-8391
We investigated whether Cirsium maritimum Makino can inhibit immunoglobulin-E-mediated allergic response in rat basophilic leukemia (RBL-2H3) cells and passive cutaneous anaphylaxis (PCA) in BALB/c mice. In vitro, the ethyl acetate extract of C. mari