Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Runliu Wu, Daniel J. Klionsky, Daolin Tang, Xin Chen, Jingbo Li, Xinxin Song, Herbert J. Zeh, Yinghua Xu, Xiaoyan Wang, Rui Kang, Jiao Liu
Publikováno v:
Autophagy
Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation process that plays a complex role in cellular stress, either promoting survival or triggering death. Early studies suggest that ferroptosis, an iron-dependen
Publikováno v:
Autophagy
Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter “autophagy”) is one of the lysosome-dependent degradation systems that
Autor:
Sam C. Wang, Matthew R. Porembka, Raghav Chandra, Scott I. Reznik, Herbert J. Zeh, Neeraja Balachandar
Publikováno v:
Cancer Gene Therapy. 28:390-399
Gastric cancer is an aggressive solid-tumor malignancy with poor prognosis. The epidemiologic face of gastric cancer is changing and further insight into its heterogenous immunohistopathologic nature is needed to develop personalized therapies for sp
Autor:
Guido Kroemer, Yangchun Xie, Leng Han, Herbert J. Zeh, Enyong Dai, Jiao Liu, Rui Kang, Daniel J. Klionsky, Jing Wang, Daolin Tang
Publikováno v:
Autophagy
KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we rep
Autor:
Herbert J. Zeh, Ulka Sachdev, Sebastian Vogel, Xiangdong Cui, Pranav Murthy, Michael T. Lotze
Publikováno v:
Biochemical and Biophysical Research Communications. 508:614-619
Platelets play a critical role in the pathophysiology of peripheral arterial disease (PAD). The mechanisms by which muscle ischemia regulates aggregation of platelets are poorly understood. We have recently identified the Nod-like receptor nucleotide
Publikováno v:
Biochemical and Biophysical Research Communications. 506:278-283
Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme derived from Streptococcus that has been widely used for genome editing in a variety of organisms, including humans. Here, we report that exogenous Cas9 protein can elicit an
Publikováno v:
Autophagy. 14:2173-2175
Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system X(c)(−). However, key regulators of system X(c)(−) activity in ferroptosis remain undefined. Here, we show t
Autor:
Stephanie Downs-Canner, Yongli Shuai, Anne Moon, David L. Bartlett, Judith Andrea McCart, Heather L. Jones, Caroline J. Breitbach, Roshni Ravindranathan, Herbert J. Zeh, Mark E. O'Malley, Zong Sheng Guo
Publikováno v:
Molecular Therapy
We have conducted a phase 1 study of intravenous vvDD, a Western Reserve strain oncolytic vaccinia virus, on 11 patients with standard treatment-refractory advanced colorectal or other solid cancers. The primary endpoints were maximum tolerated dose
Autor:
Wen Hou, Herbert J. Zeh, Daolin Tang, Xinxin Song, Rui Kang, Yangchun Xie, Michael T. Lotze, Xiaofang Sun
Publikováno v:
Autophagy. 12:1425-1428
Macroautophagy/autophagy is an evolutionarily conserved degradation pathway that maintains homeostasis. Ferroptosis, a novel form of regulated cell death, is characterized by a production of reactive oxygen species from accumulated iron and lipid per
Publikováno v:
Dev Cell
Pancreatic cancer is an aggressive malignancy with changes in the tumor microenvironment. Here, we demonstrate that PINK1 and PARK2 suppressed pancreatic tumorigenesis through control of mitochondrial iron-dependent immunometabolism. Using mouse mode