Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Dipanjan Chowdhury"'
Publikováno v:
Molecular Cell. 82:2538-2540
Zhao et al. (2022) demonstrate that HIV Tat-specific factor 1, an RPA PARylation reader, recruits Topoisomerase IIβ-binding protein 1 to double-strand break sites specifically in the S phase of the cell cycle to promote homologous recombination.
Autor:
Gaofeng Cui, Veronica Rendo, Huy V. Nguyen, Nishita Parnandi, Dipanjan Chowdhury, Rameen Beroukhim, Pascal Drané, Georges Mer, Matthias Altmeyer, Maria Victoria Botuyan, Michaela Remisova
Publikováno v:
Mol Cell
53BP1 influences genome stability via two independent mechanisms: (1) regulating DNA double-strand break (DSB) repair and (2) enhancing p53 activity. We discovered a protein, Tudor-interacting repair regulator (TIRR), that associates with the 53BP1 T
Autor:
Pascal Drané, Anchal Sharma, Yizhou Joseph He, Daryl A. Ronato, Chunyu Yang, Jie Bian, Alan D. D'Andrea, Jessica L. Moore, Subhajyoti De, Panagiotis A. Konstantinopoulos, Khyati Meghani, Alexandre Detappe, Joshi Niraj, Marie-Christine Caron, John G. Doench, Dipanjan Chowdhury, David E. Root, Gaëlle Legube, Jean-Yves Masson
Publikováno v:
Nature
Nature, Nature Publishing Group, 2018, 563 (7732), pp.522-526. ⟨10.1038/s41586-018-0670-5⟩
Nature, Nature Publishing Group, 2018, 563 (7732), pp.522-526. ⟨10.1038/s41586-018-0670-5⟩
Limited DNA end resection is the key to impaired homologous recombination in BRCA1-mutant cancer cells. Here, using a loss-of-function CRISPR screen, we identify DYNLL1 as an inhibitor of DNA end resection. The loss of DYNLL1 enables DNA end resectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b966e35510cb20242f24be01764ace
https://europepmc.org/articles/PMC7155769/
https://europepmc.org/articles/PMC7155769/
Autor:
Peter Deraska, Kalindi Parmar, Geoffrey I. Shapiro, Huy V. Nguyen, Alan D. D'Andrea, Dipanjan Chowdhury, Xiaofeng Zheng, Connor E. Dunn, Timothy Branigan, Feng Li, David Kozono, James A. DeCaprio
Publikováno v:
Molecular Cell. 80:410-422.e6
While effective anti-cancer drugs targeting the CHK1 kinase are advancing in the clinic, drug resistance is rapidly emerging. Here, we demonstrate that CRISPR-mediated knockout of the little-known gene FAM122A/PABIR1 confers cellular resistance to CH
Autor:
Panagiotis A. Konstantinopoulos, Karin K. Shih, Young Eun Choi, Marie Eve Brault, Ronny Drapkin, David M. Weinstock, Tovah A. Day, Dipanjan Chowdhury, Khyati Meghani, Fanny Dao, Douglas A. Levine, Lucas Leclerc, Kevin M. Elias, Yizhou Joseph He, Ursula A. Matulonis
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 429-439 (2016)
SummaryHigh-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (i.e., platinum and poly(ADP-ribose) polymerase inhibitors [PARPis]) due to an under
Autor:
Catarina Oliveira, Dipanjan Chowdhury, Nishita Parnandi, J. Ross Chapman, James R. Thompson, Benoît Bragantini, Gaofeng Cui, Maria Victoria Botuyan, Debiao Zhao, Alexandre Detappe, Shweta Chaubey, Georges Mer, Pascal Drané, Marie Eve Brault
Dynamic protein interaction networks such as DNA double-strand break (DSB) signaling are modulated by post-translational modifications (PTMs). The DNA repair factor 53BP1 is a rare example of a protein whose PTM binding function can be switched on an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fe4c237e6413f1742a0c5b8650b051
https://doi.org/10.1038/s41594-018-0083-z
https://doi.org/10.1038/s41594-018-0083-z
Autor:
Young Eun Choi, Patryk Moskwa, Pascal O. Zinn, Sachet A. Shukla, Todd R. Golub, Clark C. Chen, Dipanjan Chowdhury, Wojciech Fendler, Anita B. Hjelmeland, Jun Lu
Publikováno v:
Molecular Cancer Research. 12:1767-1778
The efficacy of radiotherapy in many tumor types is limited by normal tissue toxicity and by intrinsic or acquired radioresistance. Therefore, it is essential to understand the molecular network responsible for regulating radiosensitivity/resistance.
Autor:
Pascal Drané, Dipanjan Chowdhury
P53-binding protein 1 (53BP1) is a multi-functional double-strand break repair protein that is essential for class switch recombination in B lymphocytes and for sensitizing BRCA1-deficient tumours to poly-ADP-ribose polymerase-1 (PARP) inhibitors. Ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613c200fa019eed44a96d0656600cb35
https://europepmc.org/articles/PMC5531635/
https://europepmc.org/articles/PMC5531635/
Autor:
Teresa Ro, Ariana Rabinowitsch, Anar K. Murphy, Jee Hyun Kim, Michael Fitzgerald, Carl L. Schildkraut, James A. Borowiec, Dipanjan Chowdhury
Publikováno v:
The Journal of Cell Biology
Phosphorylated RPA recruits repair factors to stalled forks, thereby enhancing fork integrity during replication stress.
Phosphorylation of replication protein A (RPA) by Cdk2 and the checkpoint kinase ATR (ATM and Rad3 related) during replicati
Phosphorylation of replication protein A (RPA) by Cdk2 and the checkpoint kinase ATR (ATM and Rad3 related) during replicati
Autor:
Michael S. Krangel, Anthony T. Tubbs, Yair Dorsett, Rosmy George, Beth A. Helmink, Barry P. Sleckman, Elizabeth A. W. Chan, Dipanjan Chowdhury, Baeck-Seung Lee, Anuradha Mittal, Putzer Hung, Andrea L. Bredemeyer, Nima Mosammaparast, Rohit V. Pappu
Publikováno v:
Molecular and Cellular Biology. 34:2811-2821
The resection of broken DNA ends is required for DNA double-strand break (DSB) repair by homologous recombination (HR) but can inhibit normal repair by nonhomologous end joining (NHEJ), the main DSB repair pathway in G1-phase cells. Antigen receptor