Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Cheryl H. Arrowsmith"'
Autor:
Bryan J. Fraser, Serap Beldar, Almagul Seitova, Ashley Hutchinson, Dhiraj Mannar, Yanjun Li, Daniel Kwon, Ruiyan Tan, Ryan P. Wilson, Karoline Leopold, Sriram Subramaniam, Levon Halabelian, Cheryl H. Arrowsmith, François Bénard
Publikováno v:
Nature Chemical Biology. 18:963-971
Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host cell factor for viral entry and pathogenesis of SARS-CoV-2. Specifically, TMPRSS2 proteolytically processes the SARS-CoV-2 Spike (S) protein, enabling virus-host membrane fusi
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Nature Structural & Molecular Biology. 26:863-869
Chromatin regulatory proteins are increasingly recognized as potential new drug targets. Many of these proteins harbor one or more so called ‘reader domains’ that recognize covalent modifications of lysine and arginine residues, typically on hist
Autor:
Qin Wu, David Y. Nie, Wail Ba-alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, Felipe E. Ciamponi, Jocelyn Chen, Shili Duan, Yudao Shen, Jing Liu, Sajid A. Marhon, Parinaz Mehdipour, Magdalena M. Szewczyk, Nergiz Dogan-Artun, WenJun Chen, Lan Xin Zhang, Genevieve Deblois, Panagiotis Prinos, Katlin B. Massirer, Dalia Barsyte-Lovejoy, Jian Jin, Daniel D. De Carvalho, Benjamin Haibe-Kains, XiaoJia Wang, David W. Cescon, Mathieu Lupien, Cheryl H. Arrowsmith
Publikováno v:
Nature chemical biology. 18(8)
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I protein arginine methyltransferases (PRMTs), which has antitumor
Autor:
Xiao-Ling Cockcroft, Stephan Karl Zahn, Mark Petronczki, Catherine M. Rogers, Fengling Li, Helmut Berger, Bernadette Sharps, Markus Zeeb, Ralph A. Neumüller, Mark Pearson, Dalia Barsyte-Lovejoy, Teresa Krammer, Oleg Fedorov, Barbara Müllauer, Alexander Weiss-Puxbaum, Kilian Huber, Masoud Vedadi, Magdalena M. Szewczyk, Christopher R. Vakoc, Abdellah Allali-Hassani, Tobias Wunberg, Steven Kennedy, Christoph Reiser, Michael Schleicher, Julian E. Fuchs, Cheryl H. Arrowsmith, Moriz Mayer, Jark Böttcher, Guido Boehmelt, Dietrich Böse, Alexandra Hörmann, Andreas Zoephel, Heribert Arnhof, Sandra Winkler, Darryl B. McConnell, Peter Brown, David Dilworth, Maja Corcokovic, Klaus Rumpel, Thomas Gerstberger, Nikolai Mischerikow, Carrow I. Wells, Ulrich Reiser, Daniela Häring
Publikováno v:
Nature Chemical Biology. 15:822-829
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is encoded by the WHSC1L1 gene located in the 8p11-p12 amplicon, frequently amplified in brea
Autor:
Zhen Wang, Jiemin Wong, Jiwen Li, Peter Brown, Lan Fang, Cheryl H. Arrowsmith, Yuanyong Huang, Li Kang, Menghan Li, Huifang Zhang
Publikováno v:
Oncogene. 38:5250-5264
As a transcription factor critical for embryonic and adult stem cell self-renewal and function, SOX2 gene amplification has been recognized as a driving factor for various cancers including esophageal cancer. SOX2 overexpression occurs more broadly i
Autor:
Anjana Rao, Vipul Shukla, Levon Halabelian, L. Aravind, Daniela Samaniego-Castruita, Sanjana Balagere, Cheryl H. Arrowsmith, Douglas E. Feldman
Publikováno v:
Mol Cell
HMCES (5hmC binding, embryonic stem cell-specific-protein), originally identified as a protein capable of binding 5-hydroxymethylcytosine (5hmC), an epigenetic modification generated by TET proteins, was previously reported to covalently crosslink to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14815443115721625c7cb69f7b43e373
https://europepmc.org/articles/PMC6980713/
https://europepmc.org/articles/PMC6980713/
Autor:
Cheryl H. Arrowsmith, Y. George Zheng, Houjian Cai, Xiangkun Yang, Sunjoo Kim, Michael G. Bartlett, Yingming Zhao, Xiang-Jiao Yang, Zhen Han, Hong Wu, Peter Brown, Qianjin Li, Aiping Dong, Hong Zeng, He Huang
Publikováno v:
Journal of Biological Chemistry. 293:3410-3420
Short-chain acylation of lysine residues has recently emerged as a group of reversible posttranslational modifications in mammalian cells. The diversity of acylation further broadens the landscape and complexity of the proteome. Identification of reg
Autor:
Gennady Poda, Marko Jakopović, Levon Halabelian, Methvin Isaac, Nikolina Radulovich, Michael Prakesch, Caroline Huard, Ahmed Aman, Dhananjay Joshi, Zhong Yao, Manuel Chan, Wiebke Schormann, Richard Marcellus, Babu Joseph, Rima Al-awar, Luka Drecun, Mohammed Mohammed, Li Niu, Brigitte L. Thériault, María Sánchez-Osuna, David Uehling, Ahmed Mamai, Ming-Sound Tsao, Jasmin Coulombe-Huntington, Taira Kiyota, Evelyne Lima-Fernandes, Punit Saraon, Ankit Rai, Jamie Snider, David W. Andrews, Cheryl H. Arrowsmith, Farzaneh Aboualizadeh, Natasha B. Leighl, Miroslav Samaržija, Victoria Wong, Anna Lyakisheva, Mike Tyers, Ratheesh Subramanian, Adrian G. Sacher, Fengling Li, Masoud Vedadi, Igor Stagljar, Shivanthy Pathmanathan
Publikováno v:
Journal of Molecular Biology. 433:167294
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are effective at inhibiting mutant EGFR N