Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alan Lau"'
Autor:
Neil H. James, Alan Lau, Antonio Ramos-Montoya, Gemma N Jones, Giuditta Illuzzi, Paul W. G. Wijnhoven, Katarzyna Falenta, Rebecca L. Lloyd, Lucy H. Young, Zena Wilson, Jonathan Stott, Emma Dean, Christophe D. Chabbert
Publikováno v:
Oncogene
The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib is FDA approved for the treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits PARP1/2 enzymatic activity and traps PARP1 on DNA at single-strand breaks, leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baf3724e07bec854228e122b048829f
https://www.repository.cam.ac.uk/handle/1810/322860
https://www.repository.cam.ac.uk/handle/1810/322860
Autor:
Jeffrey L. Brown, Jung-Eun Kim, Hee Jun Kim, Mark J. O'Connor, Alan Lau, Tae Yong Kim, Seock-Ah Im, Seongyeong Kim, Yaewon Yang, Yung-Jue Bang, Ahrum Min, Kyung Hun Lee, Hyemin Jang, Do Youn Oh, Miso Lee
Publikováno v:
International Journal of Cancer. 140:109-119
Ataxia telangiectasia and Rad3-related (ATR) proteins are sensors of DNA damage, which induces homologous recombination (HR)-dependent repair. ATR is a master regulator of DNA damage repair (DDR), signaling to control DNA replication, DNA repair and
Autor:
Maureen Hattersley, Gordon B. Mills, Stephen Fawell, Brandon Willis, Alan Lau, Huawei Chen, Jingwen Zhang, Corinne Reimer, Austin Dulak, Michael Zinda, Anderson T. Wang, Jenni Nikkilä
Publikováno v:
Oncogene. 37(28)
Previous reports have demonstrated that select cancers depend on BRD4 to regulate oncogenic gene transcriptional programs. Here, we describe a novel role for BRD4 in DNA damage response (DDR). BRD4 associates with and regulates the function of pre-re
Autor:
Simon Dearden, Catherine Jane Marsden, Mark J. O'Connor, Glen Hughes, Alexander J. Kvist, Juli Warwicker, Neil Gray, Sonia Eckersley, Darren Hodgson, Donna Barnes, Erica Van Dorp, Chris Harbron, Alan Lau, Helen Wombwell, Rachel Rowlinson, Roy Milner, Chris Womack, Bob Wellings
Publikováno v:
Virchows Archiv. 462:269-279
BRCA1 protein measurement has previously been evaluated as a potential diagnostic marker without reaching a conclusive recommendation. In this study, we applied current best practice in antibody validation to further characterize MS110, a widely used
Autor:
Alan Lau, Gabriela Korinkova, Kamila Wolanin, Mark J. O'Connor, Jan Bouchal, Dana Simkova, Jiri Bartek, Martin Mistrik, René Lenobel, Jiri Lukas, Lenka Oplustilova, Jirina Bartkova
Publikováno v:
Cell Cycle. 11:3837-3850
Impaired DNA damage response pathways may create vulnerabilities of cancer cells that can be exploited therapeutically. One such selective vulnerability is the sensitivity of BRCA1- or BRCA2-defective tumors (hence defective in DNA repair by homologo
Autor:
Jiri Bartek, Zena Wilson, Lucy H. Young, Mark J. O'Connor, Corinne Reimer, Alan Lau, Lenka Oplustil O'Connor
Publikováno v:
Cancer Research. 78:2826-2826
The checkpoint kinases ATR and WEE1 protect cells from replication stress (RS), a hallmark of cancer that has potential to be exploited for cancer treatment. ATR and WEE1 inhibitors are in early clinical trials. Here we report selective anti-tumour a
Autor:
Peijun Wu, Andrew Tutt, James Carmichael, Marja Mergui-Roelvink, Peter C.C. Fong, Alan Lau, Helen Swaisland, Alan Ashworth, Peter S. Mortimer, Timothy A. Yap, Stan B. Kaye, D. S. Boss, Jan H.M. Schellens, Johann S. de Bono, Mark J. O'Connor
Publikováno v:
New England Journal of Medicine. 361:123-134
The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific DNA-repair defects, including those arising in carriers of a BRCA1 or BRCA2 m
Publikováno v:
DNA Repair. 4:583-593
Specialized DNA polymerases are required to bypass DNA damage lesions that would otherwise cause replication arrest and cell death. When operating on non-canonical templates, such as undamaged DNA or on non-cognate lesions, these polymerases exhibit
Publikováno v:
EMBO Journal, 23, 3421-3429. Wiley-Blackwell
Reverse transcription of retroviral RNA into linear double-stranded DNA and its integration into the host cell genome are essential steps in the retroviral life cycle. The nonhomologous end-joining (NHEJ) DNA repair pathway has been implicated in pro
Autor:
Frances M. Richards, Duncan I. Jodrell, Yann Wallez, Venkata Sai Vivek Bhogadi, Siang-Boon Koh, Alan Lau
Publikováno v:
Molecular Cancer Research. 15:B19-B19
Mutations in oncogenes, tumor suppressor and DNA damage response (DDR) mediator genes drive or permit malignant transformation but also increase endogenous replication stress. The serine/threonine kinase ATR plays a critical role in safeguarding geno