Zobrazeno 1 - 10
of 10
pro vyhledávání: '"A. Al-Obeidi"'
Autor:
John N. Hutchinson, Alex Thompson, Jennifer D. Helble, Daniel E. Bauer, Meghan Bliss-Moreau, Ben A. Croker, Kimberly Stegmaier, Lorena Pantano, Kathleen Hanlon, Gabriela Alexe, Shu Wang, Arshed Al-Obeidi
Publikováno v:
Cancer Genet
Genetic modification of human leukemic cell lines using CRISPR-Cas9 has become a staple of gene-function studies. Single-cell cloning of modified cells is frequently used to facilitate studies of gene function. Inherent in this approach is an assumpt
Autor:
Mathilde Gavillet, Shu Wang, Ben A. Croker, David A. Williams, Michelle A. Kelliher, Meghan Bliss-Moreau, Sylvia Dietrich, Manolis Pasparakis, Alyce A. Chen, Akshay A. D’Cruz, Mary Speir, James E Vince, Arshed Al-Obeidi, Kate E. Lawlor, Maria Ericsson, Razq Hakem
Publikováno v:
Science signaling. 11(546)
Neutrophil extracellular trap (NET) formation can generate short-term, functional anucleate cytoplasts and trigger loss of cell viability. We demonstrated that the necroptotic cell death effector mixed lineage kinase domain–like (MLKL) translocated
Autor:
John R. Yates, Magda Stankova, Aaron Aslanian, Li Ma, Jacques Mauger, Stephen Rush Fuhs, Alan Binnie, Tony Hunter, Fahad Al-Obeidi, Anna Zagórska, Greg Lemke, Jill Meisenhelder
Publikováno v:
Cell. 162(1):198-210
SummaryHistidine phosphorylation (pHis) is well studied in bacteria; however, its role in mammalian signaling remains largely unexplored due to the lack of pHis-specific antibodies and the lability of the phosphoramidate (P-N) bond. Both imidazole ni
Autor:
A M al-Obeidi, Albert Light
Publikováno v:
Journal of Biological Chemistry. 266:7694-7698
The folding pathway of pancreatic serine proteases was clarified from kinetic studies on the refolding of the glutathione-mixed disulfide derivative of bovine neochymotrypsinogen. Neochymotrypsinogen is prepared from a limited proteolysis of native c
Publikováno v:
Biochemical Journal. 268:249-262
A central goal in peptide and protein research is the development of rational approaches to the design of peptide and protein ligands with specific physical, chemical, and biological properties. In the case of peptide ligands which generally act by i
Autor:
Tomi K. Sawyer, Fahad Al-Obeidi, D J Staples, Wayne L. Cody, Victor J. Hruby, Ana Maria de Lauro Castrucci, Mac E. Hadley
Publikováno v:
Peptides. 11:351-357
We investigated the structure-activity relationships of α-MSH (α-melanocyte stimulating hormone) fragment derivatives of the generic formulae Ac-α-MSH(x−13)-NH2 and Ac-α-MSH(6−x)-NH2. The minimal C-terminal sequences required for melanotropic
Autor:
Fahad Al-Obeidi, Kit S. Lam
Publikováno v:
Oncogene. 19(49)
In the last 5 years, through combinatorial chemistry, high-throughput screening, computational chemistry, and traditional medicinal chemistry, numerous inhibitors for various protein tyrosine kinases (PTKs) have been developed. The majority of these
Publikováno v:
Molecular biotechnology. 9(3)
Various techniques for generation of peptide and peptidomimetic libraries are summarized in this article. Multipin, tea bag, and split-couple-mix techniques represent the major methods used to make peptides and peptidomimetics libraries. The synthesi
Autor:
A M al-Obeidi, Albert Light
Publikováno v:
Journal of Biological Chemistry. 263:8642-8645
Size-exclusion high performance liquid chromatography was used to compare the Stokes radius of the mixed disulfide of trypsinogen refolded for 10 min with the Stokes radius of denatured trypsinogen in high concentrations of urea. After folding for 10
Autor:
Zalfa A. Abdel Malek, Norman Levine, Fahad Al-Obeidi, Athena Lemus-Wilson, Victor J. Hruby, Sterling H. Wood, Mac E. Hadley
Publikováno v:
The Journal of investigative dermatology. 89(3)
The effects of melanocyte-stimulating hormone (α-MSH) and related analogs on follicular melanogenesis in the mouse (C57BL/6JA γ ) were studied. [Nle 4 , D -Phe 7 ]-α-MSH and the related fragment analogues Ac-[Nle 4 , D -Phe 7 ]-α-MSH 4–11 -NH 2