Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tomi P. Mäkelä"'
Publikováno v:
EMBO reports. 14:741-747
Loss of primary cilia is frequently observed in tumour cells, including glioblastoma cells, and proposed to benefit tumour growth, but a causal link has not been established. Here, we show that CCRK (cell cycle-related kinase) and its substrate ICK (
Autor:
Niklas Ekman, Marianne Tiainen, Tea Vallenius, Pekka Katajisto, Tomi P. Mäkelä, Kari Vaahtomeri, Anou Londesborough
Publikováno v:
Development. 135:2331-2338
Inactivation of the tumor suppressor kinase Lkb1 in mice leads to vascular defects and midgestational lethality at embryonic day 9-11 (E9-E11). Here, we have used conditional targeting to investigate the defects underlying the Lkb1(-/-) phenotype. En
Autor:
Lina Udd, Jérôme Boudeau, Jose M. Lizcano, Simon A. Hawley, Olga Göransson, Rachel Toth, Tomi P. Mäkelä, Dario R. Alessi, D. Grahame Hardie, Maria Deak, Nick A. Morrice
Publikováno v:
The EMBO Journal. 23:833-843
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK). A total of 12 human kinases (NUAK1, NUAK2, BRS
Autor:
Tea Vallenius, Tomi P. Mäkelä
Publikováno v:
Journal of Cell Science. 115:2067-2073
In this report we have characterized a novel, ubiquitously expressed kinase, Clik1, that is predominantly nuclear and undergoes autophosphorylation. Yeast two-hybrid analysis indicated a highly specific association between Clik1 and CLP-36, which was
Autor:
Derrick J. Rossi, Eero Lehtonen, Anou Londesborough, Mark Henkemeyer, Arno Pihlak, Tomi P. Mäkelä, Nina Korsisaari
Publikováno v:
The EMBO Journal. 20:2844-2856
The trimeric Cdk7-cyclin H-Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase. Herein we report that disruption of the murine Mat1 gene lea
Autor:
Tomi P. Mäkelä, Nina Korsisaari
Publikováno v:
Journal of Biological Chemistry. 275:34837-34840
Cyclin-dependent kinase 7 (Cdk7) forms a trimeric complex with cyclin H and Mat1 to form the mammalian Cdk-activating kinase, CAK, as well as a part of the basal transcription factor TFIIH, where Cdk7 phosphorylates the C-terminal domain (CTD) of the
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9248-9251
Germ-line mutations of LKB1 ( STK11 ) lead to Peutz–Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of Lkb1 serine/threonine kinase activity. Therefore
Autor:
Arno Pihlak, Véronique Damagnez, Tomi P. Mäkelä, Damien Hermand, Guillaume Cottarel, Thomas Westerling, Jean Vandenhaute
Publikováno v:
The EMBO Journal. 17:7230-7238
Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-act
Publikováno v:
Experimental Cell Research. 242:211-221
The carboxyl-terminal domain (CTD) of the largest RNA polymerase II (pol II) subunit is a target for extensive phosphorylation in vivo. Using in vitro kinase assays it was found that several different protein kinases can phosphorylate the CTD includi
Publikováno v:
Molecular Biology of the Cell. 7:1335-1342
Transforming growth factor beta (TGF beta) inhibits cell proliferation by inducing a G1 cell-cycle arrest. Cyclin/CDK complexes have been implicated in this arrest, because TGF beta treatment leads to inhibition of cyclin/CDK activity. We have invest