Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alberto Estevez"'
Autor:
Brian Safina, Honorio Sampang, Bobby Brillantes, Christopher M. Koth, Hoangdung Ho, Shivani Ahuja, Sophia Lin, Christoph Martin Dehnhardt, Krista K. Bowman, Michael Edward Grimwood, Ping Wu, Melissa A. Starovasnik, David H. Hackos, Christine Tam, J. P. Johnson, Charles J. Cohen, Zhiwei Xie, Jian Payandeh, Yvonne Franke, Kuldip Khakh, Mary Coons, Kevin R Clark, Jun Li, Susmith Mukund, Elaine Chang, Jean-Christophe Andrez, Stephanie Shriver, Daniel F. Ortwine, Kyle Mortara, Clint Young, Alberto Estevez, Henry Verschoof, Thilo Focken, Daniel P. Sutherlin, Lunbin Deng
Publikováno v:
Science. 350
Voltage-gated sodium (Nav) channels propagate action potentials in excitable cells. Accordingly, Nav channels are therapeutic targets for many cardiovascular and neurological disorders. Selective inhibitors have been challenging to design because the
Autor:
Alberto Estevez, Patrick J. Lupardus, Gerald R. Nakamura, Henry Chiu, Jeremy Stinson, Lynn Kamen, Lee R. Swem, Nan Chiang, Ning Chai, Summer Park, Elviza Kho, Zora Modrusan, Min Xu, Mike Reichelt, Zhonghua Lin, Elizabeth Skippington, Man-Wah Tan, Claudio Ciferri, Rina Fong
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-2 (2017)
Nature Communications
Nature Communications
Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46B8 that neutralizes all IBVs tested in vitro and protects mice against letha
Autor:
William D. Shrader, Wendy B. Young, Christine Yu, Jie Tang, Paul A. Sprengeler, Douglas A. Jeffery, Jeff Spencer, Steven R. Williams, Alberto Estevez, Bradley A. Katz, Eric B. Springman, Mary E. McGrath, Jun Sampang
Publikováno v:
Journal of Biological Chemistry. 280:41077-41089
Plasma kallikrein is a serine protease that has many important functions, including modulation of blood pressure, complement activation, and mediation and maintenance of inflammatory responses. Although plasma kallikrein has been purified for 40 year
Autor:
Alexandra Minn, Azadeh Madjidi, Vicki Chiang, Jesus Rondon, Bernard B. Allan, Christopher M. Koth, Susmith Mukund, Isidro Hötzel, Yingnan Zhang, Holly J. Clarke, Jeremy Murray, Elizabeth Luis, Alberto Estevez, Wong Terence
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(36)
Members of the class B family of G protein-coupled receptors (GPCRs) bind peptide hormones and have causal roles in many diseases, ranging from diabetes and osteoporosis to anxiety. Although peptide, small-molecule, and antibody inhibitors of these G