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pro vyhledávání: '"Joanna Parkinson"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 108-118 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
This analysis reports a quantitative modeling and simulation approach for oral dapagliflozin, a primarily uridine diphosphate-glucuronosyltransferase (UGT)-metabolized human sodium-glucose cotransporter 2 selective inhibitor. A mechanistic dapagliflo
Autor:
Fredrik Olsson, Joanna Parkinson, Camilla Niva, Johan Lundkvist, Sandra A.G. Visser, Erno van Schaick
Publikováno v:
European Journal of Clinical Pharmacology. 69:1247-1260
To date, γ-secretase inhibition is the most frequently studied mechanism of reducing Aβ in clinical trials with as yet no therapeutic success for AD patients, as measured by the slowing down of cognitive decline or an improvement in cognitive funct
Publikováno v:
British journal of clinical pharmacology. 82(6)
The integrated glucose-insulin (IGI) model is a semi-mechanistic physiological model which can describe the glucose-insulin homeostasis system following various glucose challenge settings. The aim of the present work was to apply the model to a large
Autor:
Matthew Clark, Joanna Parkinson, Lorna Ewart, Jean Pierre Valentin, Daniel Muthas, Scott Boyer
Publikováno v:
Toxicological Sciences. 126:275-284
The therapeutic value of many drugs can be limited by gastrointestinal (GI) adverse effects such as nausea and vomiting. Nausea is a subjective human sensation, hence little is known about preclinical biomarkers that may accurately and effectively pr
Publikováno v:
Journal of pharmacological and toxicological methods. 79
Introduction: Pharmacokinetic-pharmacodynamic (PKPD) modelling can improve safety assessment, but few PKPD models describing drug-induced QRS and PR prolongations have been published. This investigation aims to develop and evaluate PKPD models for de
Autor:
Joanna Parkinson, Chris E. Pollard, Sandra A.G. Visser, Jean-Pierre Valentin, James W.T. Yates, Lorna Ewart, Philip Jarvis
Publikováno v:
Journal of pharmacological and toxicological methods. 68(3)
Introduction Preclinical assessment of the heart rate corrected QT interval (QTc) is an important component of the cardiovascular safety evaluation in drug discovery. Here we aimed to quantify the translational relationship between QTc prolongation a