Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christopher J. Schofield"'
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Autor:
Liudi Yao, Christopher J Brereton, Elizabeth R Davies, Yilu Zhou, Milica Vukmirovic, Joseph A Bell, Siyuan Wang, Robert A Ridley, Lareb SN Dean, Orestis G Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M Ewing, Aiman Alzetani, Benjamin G Marshall, Sophie V Fletcher, Philipp J Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J Schofield, Matthew Loxham, Donna E Davies, Yihua Wang, Mark G Jones
Publikováno v:
eLife. 11
Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-functio
Publikováno v:
Journal of medicinal chemistry. 64(11)
Factor inhibiting hypoxia-inducible factor (FIH) is a JmjC domain 2-oxogluarate and Fe(II)-dependent oxygenase that catalyzes hydroxylation of specific asparagines in the C-terminal transcriptional activation domain of hypoxia-inducible factor alpha
Publikováno v:
Journal of Cell Science
Hypoxia plays a crucial role at cellular and physiological levels in all animals. The responses to chronic hypoxia are, at least substantially, orchestrated by activation of the hypoxia inducible transcription factors (HIFs), whose stability and subs
Autor:
Emily Flashman, Holger B. Kramer, Nikita D. Loik, Christopher J. Schofield, Emily A. Howe, Hanna Tarhonskaya, James S. O. McCullagh, Adam P. Hardy
Publikováno v:
The Journal of Biological Chemistry
Background: The hypoxia-inducible factor (HIF) hydroxylases (FIH and PHDs) regulate hypoxia sensing in animals. Results: FIH·HIF-α reacts faster with O2 than PHD2·HIF-α but slower than FIH·ankyrin complexes. Conclusion: The kinetics of catalysis
Autor:
Luke A McNeill, Shoumo Bhattacharya, Richard W.D. Welford, Christopher J. Schofield, Christopher W. Pugh, Neil J. Oldham, Madeline V. Riordan, Ya-Min Tian, Kirsty S. Hewitson, Jonathan M. Gleadle, Alex N. Bullock, Jonathan M. Elkins, Peter J. Ratcliffe
Publikováno v:
Flinders University PURE
Activity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by 2-oxoglutarate (2-OG)-dependent oxygenases mediates ubiquitinylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb81380424d2c8e28a492fd52dd26926
https://doi.org/10.1074/jbc.c200273200
https://doi.org/10.1074/jbc.c200273200
Autor:
Mariola J. Edelmann, David E. Lancaster, Kristina M. Cook, Jasmin Mecinović, Neil J. Oldham, Michael A. McDonough, Peter J. Ratcliffe, Mathew L. Coleman, Benedikt M. Kessler, C.H. Coles, Matthew E. Cockman, Kirsty S. Hewitson, Christopher J. Schofield
The stability and activity of hypoxia-inducible factor (HIF) are regulated by the post-translational hydroxylation of specific prolyl and asparaginyl residues. We show that the HIF asparaginyl hydroxylase, factor inhibiting HIF (FIH), also catalyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49caf3bb617c416f293f775fe9cd5767
https://ora.ox.ac.uk/objects/uuid:74826a6b-6a38-4c6a-a6bd-6253c0621f10
https://ora.ox.ac.uk/objects/uuid:74826a6b-6a38-4c6a-a6bd-6253c0621f10
Autor:
Michael A. McDonough, Holger B. Kramer, Timothy D. W. Claridge, Ming Yang, Wei Ge, Rasheduzzaman Chowdhury, Christopher J. Schofield, Bernhard Schmierer, Mathew L. Coleman, Peter J. Ratcliffe, Benedikt M. Kessler, Lingzhi Gong
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an asparagine residue in the C-terminal transcriptional activation domain of the hypoxia inducible factor (HIF), a modification that negatively regulates HIF transcrip
Publikováno v:
Journal of Molecular Biology. 392:994-1006
Recent reports have provided evidence that the beta-hydroxylation of conserved asparaginyl residues in ankyrin repeat domain (ARD) proteins is a common posttranslational modification in animal cells. Here, nuclear magnetic resonance (NMR) and other b
Autor:
Emily Flashman, Kirsty S. Hewitson, Dominic Ehrismann, Nicolas Mathioudakis, Peter J. Ratcliffe, David N. Genn, Christopher J. Schofield
Publikováno v:
Biochemical Journal. 401:227-234
The activity and levels of the metazoan HIF (hypoxia-inducible factor) are regulated by its hydroxylation, catalysed by 2OG (2-oxoglutarate)- and Fe(II)-dependent dioxygenases. An oxygen consumption assay was developed and used to study the relations
Publikováno v:
Biochemical Society Transactions. 32:943-945
FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl β-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor