Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Timothy Searls, Kathryn L. Kavanagh, Udo Oppermann, Michael A. McDonough, Danica Butler, Christopher J. Schofield
Refsum disease (RD), a neurological syndrome characterized by adult onset retinitis pigmentosa, anosmia, sensory neuropathy, and phytanic acidaemia, is caused by elevated levels of phytanic acid. Many cases of RD are associated with mutations in phyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30c0ca4b63f2071d7bb84de101270b5
https://doi.org/10.1074/jbc.m507528200
https://doi.org/10.1074/jbc.m507528200
Autor:
Emily Flashman, Kirsty S. Hewitson, Dominic Ehrismann, Nicolas Mathioudakis, Peter J. Ratcliffe, David N. Genn, Christopher J. Schofield
Publikováno v:
Biochemical Journal. 401:227-234
The activity and levels of the metazoan HIF (hypoxia-inducible factor) are regulated by its hydroxylation, catalysed by 2OG (2-oxoglutarate)- and Fe(II)-dependent dioxygenases. An oxygen consumption assay was developed and used to study the relations
Autor:
Anthony S. Wierzbicki, Ian J. Clifton, Nadia J. Kershaw, Winnie Chien, Mridul Mukherji, Matthew D. Lloyd, Christopher J. Schofield
Publikováno v:
Human Molecular Genetics. 10:1971-1982
Refsum's disease is a neurological syndrome characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy and phytanic acidaemia. Many cases are caused by mutations in peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PAHX) which ca
Autor:
Eleanor A.L. Bagg, Vasilij Koshkin, Sergey N. Krylov, Svetlana M. Krylova, Christopher J. Schofield
Publikováno v:
Journal of medicinal chemistry. 55(7)
The Escherichia coli (E. coli) AlkB protein and its functional human homologues belong to a subfamily of 2-oxoglutarate (2OG) dependent oxygenases (2OG oxygenases for simplicity) that enable the repair of cytotoxic methylation damage in nucleic acids
Autor:
David W. Wegman, Michael A. McDonough, Dack Kevin Neil, Marina Demetriades, Sergey N. Krylov, Louise J. Walport, Eleanor A.L. Bagg, Mun Chiang Chan, Jerome Ma, Svetlana M. Krylova, Wei Shen Aik, Esther C. Y. Woon, Christopher J. Schofield
Publikováno v:
Journal of Medicinal Chemistry
2-Oxoglutarate-dependent nucleic acid demethylases are of biological interest because of their roles in nucleic acid repair and modification. Although some of these enzymes are linked to physiology, their regulatory roles are unclear. Hence, there is
Autor:
Anna A. Karkhanina, Michael U. Musheev, Eleanor A.L. Bagg, Sergey N. Krylov, Christopher J. Schofield, Svetlana M. Krylova
Publikováno v:
Analytical Biochemistry.
The AlkB family of oxygenases catalyze the removal of alkyl groups from nucleic acid substrates in an iron and 2-oxoglutarate-dependent manner and have roles including in DNA repair. To understand the biological functions of these DNA-dealkylating en
Autor:
Kirsty S. Hewitson, Adam P. Hardy, Samantha L. Holmes, Rasheduzzaman Chowdhury, Christopher J. Schofield, Michael A. McDonough, Dominic Ehrismann
Publikováno v:
The Journal of biological chemistry. 283(38)
A 2-His-1-carboxylate triad of iron binding residues is present in many non-heme iron oxygenases including the Fe(II) and 2-oxoglutarate (2OG)-dependent dioxygenases. Three variants (D201A, D201E, and D201G) of the iron binding Asp-201 residue of an
Autor:
Ronald T. Hay, Kirsty S. Hewitson, Xiaohong Yu, Matthew E. Cockman, Christopher W. Pugh, Norma Masson, Ineke P. Stolze, Peter J. Ratcliffe, David E. Lancaster, Mathew L. Coleman, Steven C. Ley, C.H. Coles, Michael A. McDonough, Neil J. Oldham, Christopher J. Schofield
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(40)
Studies on hypoxia-sensitive pathways have revealed a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The recognition of these unprecedented signaling processes has led to
Autor:
Jonathan J, Turnbull, Jun-Ichiro, Nakajima, Richard W D, Welford, Mami, Yamazaki, Kazuki, Saito, Christopher J, Schofield
Publikováno v:
The Journal of biological chemistry. 279(2)
Anthocyanidin synthase (ANS), flavonol synthase (FLS), and flavanone 3beta-hydroxylase (FHT) are involved in the biosynthesis of flavonoids in plants and are all members of the family of 2-oxoglutarate- and ferrous iron-dependent oxygenases. ANS, FLS